L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
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Journal ArticleDOI
Natural Killer Cells in Perinatally HIV-1-Infected Children Exhibit Less Degranulation Compared to HIV-1-Exposed Uninfected Children and Their Expression of KIR2DL3, NKG2C, and NKp46 Correlates with Disease Severity
Wassim M. Ballan,Bien-Aimee N. Vu,Brian Long,Christopher P. Loo,Jakob Michaëlsson,Jason D. Barbour,Lewis L. Lanier,Andrew Wiznia,Jacobo Abadi,Glenn J. Fennelly,Michael G. Rosenberg,Douglas F. Nixon +11 more
TL;DR: It is shown that HIV-1-infected children retain a large population of cytotoxically dysfunctional NK cells relative to perinatally exposed uninfected children, and this reduced function appears concurrently with distinct NK cell surface receptor expression and is associated with a loss of CD4+ T cells.
Journal Article
Identification of a novel T cell surface disulfide-bonded dimer distinct from the alpha/beta antigen receptor.
R. Nagasawa,Jane A. Gross,O. Kanagawa,K. Townsend,Lewis L. Lanier,J M Chiller,James P. Allison +6 more
TL;DR: Cross-linking studies performed with a cleavable reagent indicated that the A1 molecule, unlike the antigen receptor defined with MAb 124-40, was not associated with additional, T3-like structures on the surface of C6VLB cells.
Journal Article
Expression of Leu-19 (NKH-1) antigen on IL 2-dependent cytotoxic and non-cytotoxic T cell lines.
Lewis L. Lanier,An My Le,A. Ding,E. L. Evans,Alan M. Krensky,Carol Clayberger,Joseph H. Phillips +6 more
TL;DR: It is demonstrated that the Leu-19 (NKH-1) antigen is also expressed on most interleukin 2 (IL 2) dependent T cell lines and clones that have been maintained in long term culture.
Journal ArticleDOI
Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function
Molly F. Thomas,Sarah Abdul-Wajid,Marisella Panduro,Joshua E. Babiarz,Misha Rajaram,Prescott G. Woodruff,Lewis L. Lanier,Vigo Heissmeyer,K. Mark Ansel +8 more
TL;DR: It is shown that mice deficient in Eri1, a conserved 3'-to-5' exoribonuclease that represses RNA interference, have a cell-intrinsic defect in NK-cell development and maturation, and miRNAs are identified as the major endogenous small RNA target of Ei1 in mouse lymphocytes.
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Elevated Frequency of Gamma Interferon-Producing NK Cells in Healthy Adults Vaccinated against Influenza Virus
Brian Long,Jakob Michaëlsson,Christopher P. Loo,Wassim M. Ballan,Bien-Aimee N. Vu,Frederick Hecht,Lewis L. Lanier,Joan M. Chapman,Douglas F. Nixon +8 more
TL;DR: Increased innate and adaptive cellular immune responses are demonstrated and it is shown that NK cells are a significant source of gamma interferon (IFN-γ) following influenza virus vaccination.