T
Tobias J. Weismüller
Researcher at University Hospital Bonn
Publications - 93
Citations - 3746
Tobias J. Weismüller is an academic researcher from University Hospital Bonn. The author has contributed to research in topics: Primary sclerosing cholangitis & Liver transplantation. The author has an hindex of 24, co-authored 80 publications receiving 3151 citations. Previous affiliations of Tobias J. Weismüller include University of Mainz & University of Bonn.
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Journal ArticleDOI
Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis
Tobias J. Weismüller,Tobias J. Weismüller,Palak J. Trivedi,Annika Bergquist,Mohamad Imam,Mohamad Imam,Henrike Lenzen,Cyriel Y. Ponsioen,Kristian Holm,Daniel Gotthardt,Martti Färkkilä,Hanns-Ulrich Marschall,Douglas Thorburn,Rinse K. Weersma,Johan Fevery,Tobias Mueller,Olivier Chazouillères,Kornelius Schulze,Konstantinos N. Lazaridis,Sven Almer,Stephen P. Pereira,Cynthia Levy,Andrew Mason,Sigrid Næss,Sigrid Næss,Christopher L. Bowlus,Annarosa Floreani,Emina Halilbasic,Kidist K. Yimam,Piotr Milkiewicz,Piotr Milkiewicz,Ulrich Beuers,Dep Huynh,Albert Parés,Christine N. Manser,George N. Dalekos,Bertus Eksteen,Pietro Invernizzi,Christoph P. Berg,Gabi I. Kirchner,Christoph Sarrazin,Vincent Zimmer,Luca Fabris,Felix Braun,Marco Marzioni,Brian D. Juran,Karouk Said,Christian Rupp,Kalle Jokelainen,Maria Benito de Valle,Francesca Saffioti,Angela Cheung,Michael Trauner,Christoph Schramm,Roger W. Chapman,Roger W. Chapman,Tom H. Karlsen,Tom H. Karlsen,Erik Schrumpf,Erik Schrumpf,Christian P. Strassburg,Michael P. Manns,Keith D. Lindor,Keith D. Lindor,Gideon M. Hirschfield,Bettina E. Hansen,Bettina E. Hansen,Bettina E. Hansen,Kirsten Muri Boberg,Kirsten Muri Boberg +69 more
TL;DR: In an analysis of data from individual patients with PSC worldwide, significant variation in clinical course associated with age at diagnosis, sex, and ductal and IBD subtypes is found.
Journal ArticleDOI
Genome-Wide Association Analysis in Primary Sclerosing Cholangitis
Tom H. Karlsen,Andre Franke,Espen Melum,Arthur Kaser,Johannes R. Hov,Tobias Balschun,Benedicte A. Lie,Annika Bergquist,Christoph Schramm,Tobias J. Weismüller,Daniel Gotthardt,Christian Rust,Eva E. R. Philipp,Teresa Fritz,Liesbet Henckaerts,Rinse K. Weersma,Pieter C. F. Stokkers,Cyriel Y. Ponsioen,Cisca Wijmenga,Martina Sterneck,Michael Nothnagel,Jochen Hampe,Andreas Teufel,Heiko Runz,Philip Rosenstiel,Adolf Stiehl,Severine Vermeire,Ulrich Beuers,Michael P. Manns,Erik Schrumpf,Kirsten Muri Boberg,Stefan Schreiber +31 more
TL;DR: Strong HLA associations and a subset of genes involved in bile homeostasis and other inflammatory conditions constitute key components of the genetic architecture of PSC.
Journal ArticleDOI
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Jimmy Z. Liu,Johannes R. Hov,Trine Folseraas,Trine Folseraas,Eva Ellinghaus,Simon M. Rushbrook,Nadezhda Tsankova Doncheva,Ole A. Andreassen,Ole A. Andreassen,Rinse K. Weersma,Tobias J. Weismüller,Bertus Eksteen,Pietro Invernizzi,Gideon M. Hirschfield,Gideon M. Hirschfield,Daniel Gotthardt,Albert Parés,David Ellinghaus,Tejas Shah,Brian D. Juran,Piotr Milkiewicz,Christian Rust,Christoph Schramm,Tobias Müller,Brijesh Srivastava,Georgios N. Dalekos,Markus M. Nöthen,Stefan Herms,Juliane Winkelmann,Mitja Mitrovic,Felix Braun,Cyriel Y. Ponsioen,Peter J. P. Croucher,Martina Sterneck,Andreas Teufel,Andrew Mason,Janna Saarela,Virpi Leppa,Ruslan Dorfman,Domenico Alvaro,Annarosa Floreani,Suna Onengut-Gumuscu,Stephen S. Rich,Wesley K. Thompson,Andrew J. Schork,Sigrid Næss,Sigrid Næss,Ingo Thomsen,Gabriele Mayr,Inke R. König,Kristian Hveem,Isabelle Cleynen,Isabelle Cleynen,Javier Gutierrez-Achury,Isis Ricaño-Ponce,David A. van Heel,Einar Björnsson,Richard Sandford,Peter R. Durie,Espen Melum,Espen Melum,Morten H. Vatn,Morten H. Vatn,Morten H. Vatn,Mark S. Silverberg,Richard H. Duerr,Leonid Padyukov,Stephan Brand,Miquel Sans,Vito Annese,Jean-Paul Achkar,Jean-Paul Achkar,Kirsten Muri Boberg,Kirsten Muri Boberg,Hanns-Ulrich Marschall,Olivier Chazouillères,Christopher L. Bowlus,Cisca Wijmenga,Erik Schrumpf,Erik Schrumpf,Severine Vermeire,Mario Albrecht,John D. Rioux,John D. Rioux,Graeme J.M. Alexander,Annika Bergquist,Judy H. Cho,Stefan Schreiber,Michael P. Manns,Martti Färkkilä,Anders M. Dale,Roger W. Chapman,Konstantinos N. Lazaridis,Andre Franke,Carl A. Anderson,Tom H. Karlsen +95 more
TL;DR: This analysis compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip to identify 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16.
Journal ArticleDOI
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Espen Melum,Andre Franke,Christoph Schramm,Tobias J. Weismüller,Daniel Gotthardt,Felix Offner,Brian D. Juran,Jon K. Laerdahl,Verena Labi,Einar Björnsson,Rinse K. Weersma,Liesbet Henckaerts,Andreas Teufel,Christian Rust,Eva Ellinghaus,Tobias Balschun,Kirsten Muri Boberg,David Ellinghaus,Annika Bergquist,Peter Sauer,Euijung Ryu,Johannes R. Hov,Jochen Wedemeyer,Björn Lindkvist,Michael Wittig,Robert J. Porte,Kristian Holm,Christian Gieger,H-Erich Wichmann,Pieter C. F. Stokkers,Cyriel Y. Ponsioen,Heiko Runz,Adolf Stiehl,Cisca Wijmenga,Martina Sterneck,Severine Vermeire,Ulrich Beuers,Andreas Villunger,Erik Schrumpf,Konstantinos N. Lazaridis,Michael P. Manns,Stefan Schreiber,Tom H. Karlsen +42 more
TL;DR: A genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls found non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11.
Journal ArticleDOI
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
Trine Folseraas,Trine Folseraas,Espen Melum,Espen Melum,Philipp Rausch,Brian D. Juran,Eva Ellinghaus,Alexey Shiryaev,Alexey Shiryaev,Jon K. Laerdahl,Jon K. Laerdahl,David Ellinghaus,Christoph Schramm,Tobias J. Weismüller,Daniel Gotthardt,Johannes R. Hov,Johannes R. Hov,Ole Petter F. Clausen,Ole Petter F. Clausen,Rinse K. Weersma,Marcel Janse,Kirsten Muri Boberg,Einar Bjornsson,Hanns-Ulrich Marschall,Isabelle Cleynen,Philip Rosenstiel,Kristian Holm,Andreas Teufel,Christian Rust,Christian Gieger,H-Erich Wichmann,Annika Bergquist,Euijung Ryu,Cyriel Y. Ponsioen,Heiko Runz,Martina Sterneck,Severine Vermeire,Ulrich Beuers,Cisca Wijmenga,Erik Schrumpf,Erik Schrumpf,Michael P. Manns,Konstantinos N. Lazaridis,Stefan Schreiber,John F. Baines,Andre Franke,Tom H. Karlsen,Tom H. Karlsen +47 more
TL;DR: It is found that FUT2 secretor status and genotype defined by rs601338 significantly influence biliary microbial community composition in PSC patients, and multiple new PSC risk loci are identified by extended analysis of a GWAS.