M
Marc Jan Bonder
Researcher at European Bioinformatics Institute
Publications - 117
Citations - 15800
Marc Jan Bonder is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: DNA methylation & Expression quantitative trait loci. The author has an hindex of 46, co-authored 108 publications receiving 10517 citations. Previous affiliations of Marc Jan Bonder include Netherlands Cancer Institute & German Cancer Research Center.
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Journal ArticleDOI
The effect of host genetics on the gut microbiome
Marc Jan Bonder,Alexander Kurilshikov,Alexander Kurilshikov,Ettje F. Tigchelaar,Zlatan Mujagic,Floris Imhann,Arnau Vich Vila,Patrick Deelen,Tommi Vatanen,Tommi Vatanen,Melanie Schirmer,Melanie Schirmer,Sanne P. Smeekens,Daria V. Zhernakova,Soesma A Jankipersadsing,Martin Jaeger,Marije Oosting,María Carmen Cenit,Ad A.M. Masclee,Morris A. Swertz,Yang Li,Vinod Kumar,Leo A. B. Joosten,Hermie J. M. Harmsen,Rinse K. Weersma,Lude Franke,Marten H. Hofker,Ramnik J. Xavier,Daisy Jonkers,Mihai G. Netea,Cisca Wijmenga,Jingyuan Fu,Alexandra Zhernakova +32 more
TL;DR: The results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health and demonstrate the influence of host genetics on microbial species, pathways and gene ontology categories on the basis of metagenomic sequencing in 1,514 subjects.
Journal ArticleDOI
Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease
Floris Imhann,Arnau Vich Vila,Marc Jan Bonder,Jingyuan Fu,Dirk Gevers,Marijn C. Visschedijk,Lieke M. Spekhorst,Rudi Alberts,Lude Franke,Hendrik M. van Dullemen,Rinze W. F. ter Steege,Curtis Huttenhower,Curtis Huttenhower,Gerard Dijkstra,Ramnik J. Xavier,Ramnik J. Xavier,Eleonora A. M. Festen,Cisca Wijmenga,Alexandra Zhernakova,Rinse K. Weersma +19 more
TL;DR: It is shown for the first time that genetic risk variants associated with IBD influence the gut microbiota in healthy individuals.
Posted ContentDOI
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
Urmo Võsa,Annique Claringbould,Harm-Jan Westra,Marc Jan Bonder,Patrick Deelen,Biao Zeng,Holger Kirsten,Ashis Saha,Roman Kreuzhuber,Silva Kasela,Natalia Pervjakova,Alvaes I,Marie-Julie Favé,Mawusse Agbessi,Mark W. Christiansen,Rick Jansen,Ilkka Seppälä,Lin Tong,Alexander Teumer,Katharina Schramm,Gibran Hemani,Joost Verlouw,Hanieh Yaghootkar,Reyhan Sonmez,Andrew A. Brown,Andrew A. Brown,Kukushkina,Anette Kalnapenkis,Sina Rüeger,Eleonora Porcu,Jaanika Kronberg-Guzman,Jarno Kettunen,Joseph E. Powell,Bernett Lee,Futao Zhang,Wibowo Arindrarto,Frank Beutner,Harm Brugge,Dmitreva J,Mahmoud Elansary,Benjamin P. Fairfax,Michel Georges,Bastiaan T. Heijmans,Mika Kähönen,Yungil Kim,Julian C. Knight,Peter Kovacs,Knut Krohn,Shuang Li,Markus Loeffler,Urko M. Marigorta,Hailiang Mei,Yukihide Momozawa,Martina Müller-Nurasyid,Matthias Nauck,Michel G. Nivard,Brenda W.J.H. Penninx,Jonathan K. Pritchard,Olli T. Raitakari,Rotzchke O,Eline Slagboom,Coen D.A. Stehouwer,Michael Stumvoll,Patrick F. Sullivan,Peter A C 't Hoen,Joachim Thiery,Anke Tönjes,van Dongen J,van Iterson M,Jan H. Veldink,Uwe Völker,C Wijmenga,Morris A. Swertz,Anand Kumar Andiappan,Grant W. Montgomery,Samuli Ripatti,Markus Perola,Z. Kutalik,Emmanouil T. Dermitzakis,Sven Bergmann,Timothy M. Frayling,van Meurs J,Holger Prokisch,Habibul Ahsan,Brandon L. Pierce,Terho Lehtimäki,D.I. Boomsma,Bruce M. Psaty,Sina A. Gharib,Philip Awadalla,Lili Milani,Willem H. Ouwehand,Kate Downes,Oliver Stegle,Alexis Battle,Jian Yang,Peter M. Visscher,Markus Scholz,Greg Gibson,Tõnu Esko,Lude Franke +100 more
TL;DR: It is observed that cis-eQTLs can be detected for 88% of the studied genes, but that they have a different genetic architecture compared to disease-associated variants, limiting the ability to use cis- eZTLs to pinpoint causal genes within susceptibility loci.
Journal ArticleDOI
The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids
Jingyuan Fu,Marc Jan Bonder,María Carmen Cenit,Ettje F. Tigchelaar,Astrid Maatman,Jackie A M Dekens,Eelke Brandsma,Joanna Marczynska,Floris Imhann,Rinse K. Weersma,Lude Franke,Tiffany W. Poon,Ramnik J. Xavier,Dirk Gevers,Marten H. Hofker,Cisca Wijmenga,Alexandra Zhernakova +16 more
TL;DR: This research presents a novel probabilistic approach that allows us to assess the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals.
Journal ArticleDOI
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
Rudolf S N Fehrmann,Ritsert C. Jansen,Jan H. Veldink,Harm-Jan Westra,Danny Arends,Marc Jan Bonder,Jingyuan Fu,Patrick Deelen,Harry J.M. Groen,Asia Smolonska,Rinse K. Weersma,Rinse K. Weersma,Robert M. W. Hofstra,Wim A. Buurman,Sander S. Rensen,Marcel G. M. Wolfs,Mathieu Platteel,Alexandra Zhernakova,Clara C. Elbers,E Festen,Gosia Trynka,Marten H. Hofker,Christiaan G. J. Saris,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Leonard H. van den Berg,David A. van Heel,Cisca Wijmenga,Gerard J. te Meerman,Lude Franke,Lude Franke +31 more
TL;DR: Natural human genetic variation is relied upon to identify effects of variants on trans-gene expression (expression quantitative trait locus mapping, eQTL) in whole peripheral blood from 1,469 unrelated individuals, supporting the concept that the effects of these SNPs on expression seems to be much less multifactorial.