M
Marc Jan Bonder
Researcher at European Bioinformatics Institute
Publications - 117
Citations - 15800
Marc Jan Bonder is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: DNA methylation & Expression quantitative trait loci. The author has an hindex of 46, co-authored 108 publications receiving 10517 citations. Previous affiliations of Marc Jan Bonder include Netherlands Cancer Institute & German Cancer Research Center.
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Richard Karlsson Linnér,Pietro Biroli,Edward Kong,Fleur Meddens,Robbee Wedow,Mark Alan Fontana,Mael Lebreton,Stephen P. Tino,Abdel Abdellaoui,Anke R. Hammerschlag,Michel G. Nivard,Aysu Okbay,Cornelius A. Rietveld,Pascal N. Timshel,Maciej Trzaskowski,Ronald de Vlaming,Christian L. Zund,Yanchun Bao,Laura Buzdugan,Ann H. Caplin,Chia-Yen Chen,Peter Eibich,Pierre Fontanillas,Juan R. González,Peter K. Joshi,Ville Karhunen,Aaron Kleinman,Remy Z. Levin,Christina M. Lill,Gerardus A. Meddens,Gerard Muntané,Sandra Sanchez-Roige,Frank J. A. van Rooij,Erdogan Taskesen,Yang Wu,Futao Zhang,Michelle Agee,Babak Alipanahi,Robert K. Bell,Katarzyna Bryc,Sarah L. Elson,Nicholas A. Furlotte,Karen E. Huber,Nadia K. Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Joanna L. Mountain,Carrie A.M. Northover,Steven J. Pitts,J. Fah Sathirapongsasuti,Olga V. Sazonova,Janie F. Shelton,Suyash Shringarpure,Chao Tian,Joyce Y. Tung,Vladimir Vacic,Catherine H. Wilson,Mawusse Agbessi,Habibul Ahsan,Isabel Alves,Anand Kumar Andiappan,Philip Awadalla,Alexis Battle,Frank Beutner,Marc Jan Bonder,Dorret I. Boomsma,Mark W. Christiansen,Annique Claringbould,Patrick Deelen,Tõnu Esko,Marie-Julie Favé,Lude Franke,Timothy M. Frayling,Sina A. Gharib,Gregory Gibson,Bastiaan T. Heijmans,Gibran Hemani,Rick Jansen,Mika Kähönen,Anette Kalnapenkis,Silva Kasela,Johannes Kettunen,Yungil Kim,Holger Kirsten,Peter Kovacs,Knut Krohn,Jaanika Kronberg-Guzman,Viktorija Kukushkina,Zoltán Kutalik,Bernett Lee,Terho Lehtimäki,Markus Loeffler,Urko M. Marigorta,Andres Metspalu,Lili Milani,Grant W. Montgomery,Martina Mueller-Nurasyid,Matthias Nauck,Brenda W.J.H. Penninx,Markus Perola,Natalia Pervjakova,Brandon L. Pierce,Joseph E. Powell,Holger Prokisch,Bruce M. Psaty,Olli T. Raitakari,Susan M. Ring,Samuli Ripatti,Olaf Rotzchke,Sina Rüeger,Ashis Saha,Markus Scholz,Katharina Schramm,Ilkka Seppälä,Michael Stumvoll,Patrick Sullivan,Peter-Bramt Hoen,Alexander Teumer,Joachim Thiery,Lin Tong,Anke Tönjes,Jenny van Dongen,Joyce B. J. van Meurs,Joost Verlouw,Peter M. Visscher,Uwe Voelker,Urmo Võsa,Harm-Jan Westra,Hanieh Yaghootkar,Jian Yang,Biao Zeng,James J. Lee,Tune H. Pers,Patrick Turley,Guo-Bo Chen,Valur Emilsson,Sven Oskarsson,Joseph K. Pickrell,Kevin Thom,Pascal Timshel,Tarunveer S. Ahluwalia,Jonas Bacelis,Clemens Baumbach,Gyda Bjornsdottir,Johannes H. Brandsma,Maria Pina Concas,Jaime Derringer,Tessel E. Galesloot,Giorgia Girotto,Richa Gupta,Leanne M. Hall,Sarah E. Harris,Edith Hofer,Momoko Horikoshi,Jennifer E. Huffman,Kadri Kaasik,Ioanna P. Kalafati,Augustine Kong,Jari Lahti,Sven J. van der Lee,Christiaan de Leeuw,Penelope A. Lind,Karl-Oskar Lindgren,Tian Liu,Massimo Mangino,Jonathan Marten,Evelin Mihailov,Michael B. Miller,Peter J. van der Most,Christopher Oldmeadow,Antony Payton,Wouter J. Peyrot,Yong Qian,Rico Rueedi,Erika Salvi,Boerge Schmidt,Katharina E. Schraut,Jianxin Shi,Albert V. Smith,Raymond A. Poot,Beate St Pourcain,Gudmar Thorleifsson,Niek Verweij,Dragana Vuckovic,Juergen Wellmann,Jingyun Yang,Wei Zhao,Zhihong Zhu,Behrooz Z. Alizadeh,Najaf Amin,Andrew Bakshi,Sebastian E. Baumeister,Ginevra Biino,Klaus Bønnelykke,Patricia A. Boyle,Harry Campbell,Francesco P. Cappuccio,Gail Davies,Jan-Emmanuel De Neve,Panos Deloukas,Ilja Demuth,Jun Ding,Lewin Eisele,Niina Eklund,David M. Evans,Jessica D. Faul,Mary F. Feitosa,Andreas J. Forstner,Ilaria Gandin,Bjarni Gunnarsson,Bjarni V. Halldorsson,Tamara B. Harris,Andrew Heath,Lynne J. Hocking,Elizabeth G. Holliday,Georg Homuth,Michael A. Horan,Jouke-Jan Hottenga,Philip L. De Jager,Astanand Jugessur,Marika Kaakinen,Stavroula Kanoni,Liisa Keltigangas-Jarvinen,Lambertus A. Kiemeney,Ivana Kolcic,Seppo Koskinen,Aldi T. Kraja,Martin Kroh,Antti Latvala,Lenore J. Launer,Maël Lebreton,Douglas F. Levinson,Paul Lichtenstein,Peter Lichtner,David C. Liewald,Anu Loukola,Pamela A. F. Madden,Reedik Mägi,Tomi Mäki-Opas,Riccardo E. Marioni,Pedro Marques-Vidal,George McMahon,Christa Meisinger,Thomas Meitinger,Y. Milaneschi,Ronny Myhre,Christopher P. Nelson,Dale R. Nyholt,William E R Ollier,Aarno Palotie,Lavinia Paternoster,Nancy L. Pedersen,K. Petrovic,David J. Porteous,Katri Räikkönen,S M Ring,Antonietta Robino,Olga Rostapshova,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Alan R. Sanders,Antti-Pekka Sarin,Helena Schmidt,Rodney J. Scott,Blair H. Smith,Jennifer A. Smith,Jan A. Staessen,Elisabeth Steinhagen-Thiessen,Konstantin Strauch,Antonio Terracciano,Martin D. Tobin,Sheila Ulivi,Simona Vaccargiu,Lydia Quaye,Cristina Venturini,Anna A. E. Vinkhuyzen,Henry Voelzke,Judith M. Vonk,Diego Vozzi,Johannes Waage,Erin B. Ware,Gonneke Willemsen,John Attia,David A. Bennett,Klaus Berger,Lars Bertram,Hans Bisgaard,Ingrid B. Borecki,Ute Bültmann,Christopher F. Chabris,Francesco Cucca,Daniele Cusi,J. Deary,George Dedoussis,Cornelia M. van Duijn,Johan G. Eriksson,Barbara Franke,Paolo Gasparini,Pablo V. Gejman,Christian Gieger,Hans-Joergen Grabe,Jacob Gratten,Vilmundur Gudnason,Pim van der Harst,Caroline Hayward,David A. Hinds,Wolfgang Hoffmann,Elina Hyppönen,William G. Iacono,Bo Jacobsson,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Sharon L.R. Kardia,Steven F. Lehrer,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Neil Pendleton,Nicola Pirastu,Mario Pirastu,Ozren Polasek,Danielle Posthuma,Christine Power,Michael A. Province,Nilesh J. Samani,David Schlessinger,Reinhold E. Schmidt,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,André G. Uitterlinden,Veronique Vitart,Peter Vollenweider,David R. Weir,James F. Wilson,Alan F. Wright,Dalton Conley,Robert F. Krueger,George Davey Smith,David Laibson,Sarah E. Medland,Magnus Johannesson,Philipp Koellinger,David Cesarini,Daniel J. Benjamin,Adam Auton,Jason D. Boardman,David W. Clark,Andrew Conlin,Conor C. Dolan,Urs Fischbacher,Patrick J. F. Groenen,Kathleen Mullan Harris,Gregor Hasler,Albert Hofman,Mohammad Arfan Ikram,Sonia Jain,Robert Karlsson,Ronald C. Kessler,Maarten Kooyman,James MacKillop,Minna Männikkö,Carlos Morcillo-Suarez,Matthew B. McQueen,Klaus M. Schmidt,Melissa C. Smart,Matthias Sutter,Jon White,Harriet de Wit,Ernst Fehr,Meena Kumari,David Laibson,Michelle N. Meyer,Arcadi Navarro,Abraham A. Palmer,Daniel Schunk,Murray B. Stein,Rauli Svento,Paul R. H. J. Timmers,Robert J. Ursano,Gert G. Wagner,Jonathan P. Beauchamp +387 more
TL;DR: A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.
Journal ArticleDOI
Correction to: Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity
Melanie Schirmer,Sanne P. Smeekens,Hera Vlamakis,Martin Jaeger,Marije Oosting,Eric A. Franzosa,Rob ter Horst,Trees Jansen,Liesbeth Jacobs,Marc Jan Bonder,Alexander Kurilshikov,Jingyuan Fu,Leo A. B. Joosten,Alexandra Zhernakova,Curtis Huttenhower,Cisca Wijmenga,Mihai G. Netea,Ramnik J. Xavier +17 more
TL;DR: The paper accidentally included incorrect siRNA sequences for ALKBH1 in the Method Details section and the order of the complementary strand for the 6mA-containing dsDNA oligo sequence should have been reversed and listed as 50-AAATACAAGCATGCTTTTCCATAAGGTATCATG-30.
Journal ArticleDOI
Blood lipids influence DNA methylation in circulating cells
Koen F. Dekkers,Maarten van Iterson,Roderick C. Slieker,Matthijs Moed,Marc Jan Bonder,Michiel van Galen,Hailiang Mei,Daria V. Zhernakova,Leonard H. van den Berg,Joris Deelen,Jenny van Dongen,Diana van Heemst,Albert Hofman,Jouke J. Hottenga,Carla J.H. van der Kallen,Casper G. Schalkwijk,Coen D.A. Stehouwer,Ettje F. Tigchelaar,André G. Uitterlinden,Gonneke Willemsen,Alexandra Zhernakova,Lude Franke,Peter A C 't Hoen,Rick Jansen,Joyce B. J. van Meurs,Dorret I. Boomsma,Cornelia M. van Duijn,Marleen M.J. van Greevenbroek,Jan H. Veldink,Cisca Wijmenga,Erik W. van Zwet,P. Eline Slagboom,J. Wouter Jukema,Bastiaan T. Heijmans +33 more
TL;DR: A role for epigenetic priming in end-product feedback control of lipid metabolism is suggested and Mendelian randomization is highlighted as an effective tool to infer causal relationships in integrative genomics data.
Journal ArticleDOI
DNA methylation analysis identifies loci for blood pressure regulation
Melissa A. Richard,Tianxiao Huan,Symen Ligthart,Rahul Gondalia,Min A. Jhun,Jennifer A. Brody,Marguerite R. Irvin,Riccardo E. Marioni,Riccardo E. Marioni,Jincheng Shen,Pei-Chien Tsai,May E. Montasser,Yucheng Jia,Catriona Syme,Elias Salfati,Eric Boerwinkle,Eric Boerwinkle,Weihua Guan,Thomas H. Mosley,Jan Bressler,Alanna C. Morrison,Chunyu Liu,Michael M. Mendelson,André G. Uitterlinden,Joyce B. J. van Meurs,Bastiaan T. Heijmans,Peter A.C. ’t Hoen,Joyce B. C van Meurs,A Isaacs,Rick Jansen,Lude Franke,Dorret I. Boomsma,René Pool,Jenny van Dongen,Jouke J. Hottenga,Marleen M.J. van Greevenbroek,Coen D.A. Stehouwer,Carla J.H. van der Kallen,Casper G. Schalkwijk,Cisca Wijmenga,Alexandra Zhernakova,Ettje F. Tigchelaar,P. Eline Slagboom,Marian Beekman,Joris Deelen,Diana van Heemst,J. H. Veldink,Leonard H. van den Berg,Cornelia M. van Duijn,Albert Hofman,P. Mila Jhamai,Michael M. P. J. Verbiest,H. Eka D. Suchiman,Marijn Verkerk,Ruud van der Breggen,Jeroen van Rooij,Nico Lakenberg,Hailiang Mei,Maarten van Iterson,Michiel van Galen,Jan Bot,Peter Van ‘t Hof,Patrick Deelen,Irene Nooren,Matthijs Moed,Martijn Vermaat,Dasha V. Zhernakova,René Luijk,Marc Jan Bonder,Freerk van Dijk,Wibowo Arindrarto,Szymon M. Kielbasa,Morris A. Swertz,Erik W. van Zwet,Oscar H. Franco,Guosheng Zhang,Yun Li,James D. Stewart,Joshua C. Bis,Bruce M. Psaty,Yii-Der Ida Chen,Sharon L.R. Kardia,Wei Zhao,Stephen Turner,Devin Absher,Stella Aslibekyan,John M. Starr,Allan F. McRae,Lifang Hou,Allan C. Just,Joel Schwartz,Pantel S. Vokonas,Cristina Menni,Tim D. Spector,Alan R. Shuldiner,Alan R. Shuldiner,Coleen M. Damcott,Jerome I. Rotter,Walter Palmas,Yongmei Liu,Tomáš Paus,Tomáš Paus,Steve Horvath,Jeffrey R. O'Connell,Xiuqing Guo,Zdenka Pausova,Themistocles L. Assimes,Nona Sotoodehnia,Jennifer A. Smith,Donna K. Arnett,Ian J. Deary,Andrea A. Baccarelli,Jordana T. Bell,Eric A. Whitsel,Abbas Dehghan,Abbas Dehghan,Daniel Levy,Myriam Fornage +117 more
TL;DR: A two-stage meta-analysis of the cross-sectional associations of systolic and diastolic BP with blood-derived genome-wide DNA methylation measured on the Infinium HumanMethylation450 BeadChip suggests that heritableDNA methylation plays a role in regulating BP independently of previously known genetic variants.
Journal ArticleDOI
DNA methylation in childhood asthma: an epigenome-wide meta-analysis
Cheng-Jian Xu,Cilla Söderhäll,Mariona Bustamante,Nour Baïz,Olena Gruzieva,Ulrike Gehring,Dan Mason,Leda Chatzi,Leda Chatzi,Leda Chatzi,Mikel Basterrechea,Sabrina Llop,Maties Torrent,Francesco Forastiere,Maria Pia Fantini,Karin C. Lødrup Carlsen,Karin C. Lødrup Carlsen,Tari Haahtela,Andréanne Morin,Marjan Kerkhof,Simon Kebede Merid,Bianca van Rijkom,Soesma A Jankipersadsing,Marc Jan Bonder,Stephane Ballereau,Stephane Ballereau,Cornelis J. Vermeulen,Raul Aguirre-Gamboa,Johan C. de Jongste,Henriette A. Smit,Ashok Kumar,Ashok Kumar,Ashok Kumar,Göran Pershagen,Stefano Guerra,Judith Garcia-Aymerich,Dario Greco,Lovisa E. Reinius,Rosemary R. C. McEachan,Raf Azad,Vegard Hovland,Petter Mowinckel,Harri Alenius,Harri Alenius,Nanna Fyhrquist,Nanna Fyhrquist,Nathanaël Lemonnier,Nathanaël Lemonnier,Johann Pellet,Charles Auffray,Pieter van der Vlies,Cleo C. van Diemen,Yang Li,Cisca Wijmenga,Mihai G. Netea,Miriam F. Moffatt,William O.C.M. Cookson,Josep M. Antó,Jean Bousquet,Jean Bousquet,Tiina Laatikainen,Tiina Laatikainen,Catherine Laprise,Kai-Håkon Carlsen,Kai-Håkon Carlsen,Davide Gori,Daniela Porta,Carmen Iñiguez,Jose Ramon Bilbao,Manolis Kogevinas,John Wright,Bert Brunekreef,Juha Kere,Juha Kere,Martijn C. Nawijn,Isabella Annesi-Maesano,J Sunyer,Erik Melén,Erik Melén,Erik Melén,Gerard H. Koppelman +80 more
TL;DR: In this paper, a large-scale epigenome-wide association study (EWAS) within the Mechanisms of the Development of ALLergy (MeDALL) project was conducted to assess methylation profiles associated with childhood asthma.