M
Maria-Belen Trujillo-Torralbo
Researcher at National Institutes of Health
Publications - 28
Citations - 1728
Maria-Belen Trujillo-Torralbo is an academic researcher from National Institutes of Health. The author has contributed to research in topics: COPD & Rhinovirus. The author has an hindex of 14, co-authored 26 publications receiving 1366 citations. Previous affiliations of Maria-Belen Trujillo-Torralbo include Medical Research Council & Imperial College London.
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Journal ArticleDOI
IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo
David A. Jackson,David A. Jackson,Heidi Makrinioti,Batika M. J. Rana,Betty Shamji,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Joseph Footitt,Joseph Footitt,Jerico del-Rosario,Jerico del-Rosario,Aurica G. Telcian,A A Nikonova,Jie Zhu,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Stephanie Traub,Jaideep Dhariwal,Jaideep Dhariwal,James D. Porter,Duncan Hunt,Toby Hunt,Trevor Hunt,Luminita A. Stanciu,Musa Khaitov,Nathan W. Bartlett,Michael R. Edwards,Onn Min Kon,Patrick Mallia,Patrick Mallia,Nikolaos G. Papadopoulos,Cezmi A. Akdis,John Westwick,Matthew J. Edwards,David J. Cousins,Ross P. Walton,Sebastian L. Johnston,Sebastian L. Johnston +38 more
TL;DR: IL-33 and type 2 cytokines are induced during a rhinovirus-induced asthma exacerbation in vivo and relate to exacerbation severity, which is a novel therapeutic approach for asthma exacerbations.
Journal ArticleDOI
Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease
Philip L. Molyneaux,Patrick Mallia,Michael J. Cox,Joseph Footitt,Saffron A.G. Willis-Owen,Daniel Homola,Maria-Belen Trujillo-Torralbo,Sarah L. Elkin,Onn Min Kon,William O.C.M. Cookson,Miriam F. Moffatt,Sebastian L. Johnston +11 more
TL;DR: It is suggested that rhinovirus infection in COPD alters the respiratory microbiome and may precipitate secondary bacterial infections.
Journal ArticleDOI
Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease
Patrick Mallia,Joseph Footitt,Rosa Sotero,Annette Jepson,Marco Contoli,Maria-Belen Trujillo-Torralbo,Tatiana Kebadze,Julia Aniscenko,Gregory Oleszkiewicz,Katrina Gray,Simon D. Message,Kazuhiro Ito,Peter J. Barnes,Ian M. Adcock,Alberto Papi,Luminita A. Stanciu,Sarah L. Elkin,Onn Min Kon,Malcolm Johnson,Sebastian L. Johnston +19 more
TL;DR: Rinovirus infections are frequently followed by secondary bacterial infections in COPD and cleavage of the antimicrobial peptides SLPI and elafin by virus-induced neutrophil elastase may precipitate these secondaryacterial infections.
Journal ArticleDOI
Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
Aran Singanayagam,Nicholas Glanville,Jason Girkin,Yee Man Ching,Andrea Marcellini,James D. Porter,Marie Toussaint,Ross P. Walton,Lydia J. Finney,Julia Aniscenko,Jie Zhu,Maria-Belen Trujillo-Torralbo,Maria Adelaide Calderazzo,Christopher Grainge,Su-Ling Loo,Punnam Chander Veerati,Prabuddha S. Pathinayake,Kristy Nichol,Andrew T. Reid,Phillip James,Roberto Solari,Peter A. B. Wark,Darryl A. Knight,Miriam F. Moffatt,William O.C.M. Cookson,Michael R. Edwards,Patrick Mallia,Nathan W. Bartlett,Nathan W. Bartlett,Sebastian L. Johnston +29 more
TL;DR: It is shown that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ, which raises suggestion that inhaled interferon-β therapy may protect.
Journal ArticleDOI
A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).
Trevor T. Hansel,Tanushree Tunstall,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Betty Shamji,Ajerico del-Rosario,Ajerico del-Rosario,Jaideep Dhariwal,Jaideep Dhariwal,Paul D. W. Kirk,Michael P. H. Stumpf,Jens Koopmann,Jens Koopmann,Aurica G. Telcian,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Luminita A. Stanciu,Nathan W. Bartlett,Michael R. Edwards,Ross P. Walton,Patrick Mallia,Patrick Mallia,Toby Hunt,Trevor Hunt,Duncan Hunt,John Westwick,Matthew J. Edwards,Onn Min Kon,David A. Jackson,Sebastian L. Johnston,Sebastian L. Johnston +31 more
TL;DR: Precision sampling of mucosal lining fluid identifies robust interferon and type 2 responses in the upper and lower airways of asthmatics during an asthma exacerbation.