Michel Nederlof

TL;DR: The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders.

TL;DR: The Human Tumor Atlas Network (HTAN), part of the NCI Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types.

TL;DR: Different mechanisms of resistance specific to each HER2+ subtype are suggested, including MET signaling for HER2E and HER2-HER3 heterodimerization for L-HER2+ cells.

TL;DR: A library of 95 novel boron-dipyrromethene (BODIPY)-based fluorophores was synthesized and screened their photophysical, optical and spectral properties for their utility in multicolor microscopy.

TL;DR: The utility of Ab-oligo cyCIF as a platform for highly multiplexed imaging, its utility to measure tumor heterogeneity, and its potential for future use in clinical histopathology are demonstrated.