N
Nicholas A. Clark
Researcher at University of Cincinnati
Publications - 12
Citations - 636
Nicholas A. Clark is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Biology & Chemical genetics. The author has an hindex of 6, co-authored 9 publications receiving 432 citations. Previous affiliations of Nicholas A. Clark include Icahn School of Medicine at Mount Sinai.
Papers
More filters
Journal ArticleDOI
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
Alexandra B Keenan,Sherry L. Jenkins,Kathleen M. Jagodnik,Simon Koplev,Edward He,Denis Torre,Zichen Wang,Anders B. Dohlman,Moshe C. Silverstein,Alexander Lachmann,Maxim V. Kuleshov,Avi Ma'ayan,Vasileios Stathias,Raymond Terryn,Daniel J. Cooper,Michele Forlin,Amar Koleti,Dusica Vidovic,Caty Chung,Stephan C. Schürer,Jouzas Vasiliauskas,Marcin Pilarczyk,Behrouz Shamsaei,Mehdi Fazel,Yan Ren,Wen Niu,Nicholas A. Clark,Shana White,Naim Al Mahi,Lixia Zhang,Michal Kouril,John F. Reichard,Siva Sivaganesan,Mario Medvedovic,Jaroslaw Meller,Rick J. Koch,Marc R. Birtwistle,Ravi Iyengar,Eric A. Sobie,Evren U. Azeloglu,Julia A. Kaye,Jeannette Osterloh,Kelly Haston,Jaslin Kalra,Steve Finkbiener,Jonathan Z. Li,Pamela Milani,Miriam Adam,Renan Escalante-Chong,Karen Sachs,Alexander LeNail,Divya Ramamoorthy,Ernest Fraenkel,Gavin Daigle,Uzma Hussain,Alyssa Coye,Jeffrey D. Rothstein,Dhruv Sareen,Loren Ornelas,Maria G. Banuelos,Berhan Mandefro,Ritchie Ho,Clive N. Svendsen,Ryan G. Lim,Jennifer Stocksdale,Malcolm Casale,Terri G. Thompson,Jie Wu,Leslie M. Thompson,Victoria Dardov,Vidya Venkatraman,Andrea Matlock,Jennifer E. Van Eyk,Jacob D. Jaffe,Malvina Papanastasiou,Aravind Subramanian,Todd R. Golub,Sean D. Erickson,Mohammad Fallahi-Sichani,Marc Hafner,Nathanael S. Gray,Jia-Ren Lin,Caitlin E. Mills,Jeremy L. Muhlich,Mario Niepel,Caroline E. Shamu,Elizabeth H. Williams,David Wrobel,Peter K. Sorger,Laura M. Heiser,Joe W. Gray,James E. Korkola,Gordon B. Mills,Mark A. LaBarge,Mark A. LaBarge,Heidi S. Feiler,Mark A. Dane,Elmar Bucher,Michel Nederlof,Damir Sudar,Sean M. Gross,David Kilburn,Rebecca Smith,Kaylyn Devlin,Ron Margolis,Leslie Derr,Albert Lee,Ajay Pillai +107 more
TL;DR: The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders.
Journal ArticleDOI
Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data.
Amar Koleti,Amar Koleti,Raymond Terryn,Raymond Terryn,Vasileios Stathias,Vasileios Stathias,Caty Chung,Caty Chung,Daniel J. Cooper,Daniel J. Cooper,John Paul Turner,John Paul Turner,Dusica Vidovic,Dusica Vidovic,Michele Forlin,Michele Forlin,Tanya T. Kelley,Tanya T. Kelley,Alessandro D'Urso,Alessandro D'Urso,Bryce K. Allen,Bryce K. Allen,Denis Torre,Kathleen M. Jagodnik,Lily Wang,Sherry L. Jenkins,Christopher C. Mader,Christopher C. Mader,Wen Niu,Wen Niu,Mehdi Fazel,Mehdi Fazel,Naim Al Mahi,Naim Al Mahi,Marcin Pilarczyk,Marcin Pilarczyk,Nicholas A. Clark,Nicholas A. Clark,Behrouz Shamsaei,Behrouz Shamsaei,Jarek Meller,Jarek Meller,Juozas Vasiliauskas,Juozas Vasiliauskas,John F. Reichard,John F. Reichard,Mario Medvedovic,Mario Medvedovic,Avi Ma'ayan,Ajay Pillai,Stephan C. Schürer,Stephan C. Schürer +51 more
TL;DR: TheLINCS Data Portal (LDP) is described, a unified web interface to access datasets generated by the LINCS DSGCs, and its underlying database, LINCS Data Registry (LDR).
Journal ArticleDOI
GRcalculator: an online tool for calculating and mining dose–response data
Nicholas A. Clark,Marc Hafner,Michal Kouril,Elizabeth H. Williams,Jeremy L. Muhlich,Marcin Pilarczyk,Mario Niepel,Peter K. Sorger,Mario Medvedovic +8 more
TL;DR: GRcalculator is a powerful, user-friendly, and free tool that provides a unified platform for investigators to analyze dose–response data across diverse cell types and perturbagens and facilitates inclusion of GR metrics calculations within existing R analysis pipelines.
Journal ArticleDOI
Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries.
Nienke Moret,Nicholas A. Clark,Marc Hafner,Yuan Wang,Eugen Lounkine,Mario Medvedovic,Jinhua Wang,Nathanael S. Gray,Jeremy L. Jenkins,Peter K. Sorger +9 more
TL;DR: This work describes an approach to scoring and creating libraries based on binding selectivity, target coverage, and induced cellular phenotypes as well as chemical structure, stage of clinical development, and user preference, and describes a mechanism of action library that optimally covers 1,852 targets in the liganded genome.
Posted ContentDOI
Connecting omics signatures of diseases, drugs, and mechanisms of actions with iLINCS
Marcin Pilarczyk,Michal Kouril,Behrouz Shamsaei,Juozas Vasiliauskas,Wen Niu,Naim Al Mahi,Lixia Zhang,Nicholas A. Clark,Yan Ren,Shana White,Rashid Saadman Karim,Huan Xu,Jacek Biesiada,Mark F. Bennett,Sarah E. Davidson,John F. Reichard,Kurt Roberts,Vasileios Stathias,Amar Koleti,Dusica Vidovic,Daniel J.B. Clarke,Stephan C. Schürer,Avi Ma'ayan,Jarek Meller,Jarek Meller,Mario Medvedovic +25 more
TL;DR: In summary, iLINCS workflows integrate vast omics data resources and a range of analytics and interactive visualization tools into a comprehensive platform for analysis of omics signatures.