M
Mehmet Toner
Researcher at Harvard University
Publications - 572
Citations - 60830
Mehmet Toner is an academic researcher from Harvard University. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 113, co-authored 550 publications receiving 54827 citations. Previous affiliations of Mehmet Toner include University of New Mexico & University of Notre Dame.
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Journal ArticleDOI
Isolation of rare circulating tumour cells in cancer patients by microchip technology.
Sunitha Nagrath,Lecia V. Sequist,Shyamala Maheswaran,Daphne W. Bell,Daphne W. Bell,Daniel Irimia,Lindsey Ulkus,Matthew R. Smith,Eunice L. Kwak,Subba R. Digumarthy,Alona Muzikansky,Paula D. Ryan,Ulysses J. Balis,Ulysses J. Balis,Ronald G. Tompkins,Daniel A. Haber,Mehmet Toner +16 more
TL;DR: The CTC-chip successfully identified CTCs in the peripheral blood of patients with metastatic lung, prostate, pancreatic, breast and colon cancer in 115 of 116 samples, with a range of 5–1,281CTCs per ml and approximately 50% purity.
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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Min Yu,Aditya Bardia,Ben S. Wittner,Shannon L. Stott,Malgorzata E. Smas,David T. Ting,Steven J. Isakoff,Jordan C. Ciciliano,Marissa N. Wells,Ajay Shah,Kyle Concannon,Maria C. Donaldson,Lecia V. Sequist,Elena F. Brachtel,Dennis C. Sgroi,José Baselga,Sridhar Ramaswamy,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more
TL;DR: A role for EMT in the blood-borne dissemination of human breast cancer is supported as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)–β pathway components and the FOXC1 transcription factor.
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Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
Nicola Aceto,Aditya Bardia,David T. Miyamoto,Maria C. Donaldson,Ben S. Wittner,Joel A. Spencer,Min Yu,Adam Pely,Amanda Engstrom,Huili Zhu,Brian W. Brannigan,Ravi Kapur,Shannon L. Stott,Toshi Shioda,Sridhar Ramaswamy,David T. Ting,Charles P. Lin,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more
TL;DR: Using mouse models with tagged mammary tumors, it is demonstrated that CTC clusters arise from oligoclonal tumor cell groupings and not from intravascular aggregation events, and though rare in the circulation, they greatly contribute to the metastatic spread of cancer.
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Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
Shyamala Maheswaran,Lecia V. Sequist,Sunitha Nagrath,Lindsey Ulkus,Brian W. Brannigan,Chey V. Collura,Elizabeth J. Inserra,Sven Diederichs,A. John Iafrate,Daphne W. Bell,Subba R. Digumarthy,Alona Muzikansky,Alona Muzikansky,Daniel Irimia,Jeffrey Settleman,Ronald G. Tompkins,Ronald G. Tompkins,Thomas J. Lynch,Mehmet Toner,Mehmet Toner,Daniel A. Haber,Daniel A. Haber +21 more
TL;DR: Molecular analysis of circulating tumor cells from the blood of patients with lung cancer offers the possibility of monitoring changes in epithelial tumor genotypes during the course of treatment, and shows that a reduction in the number of captured cells was associated with a radiographic tumor response; an increase in theNumber of cells wasassociated with tumor progression, with the emergence of additional EGFR mutations in some cases.
Journal ArticleDOI
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
Shannon L. Stott,Chia-Hsien Hsu,Chia-Hsien Hsu,Chia-Hsien Hsu,Dina Tsukrov,Min Yu,David T. Miyamoto,Belinda A. Waltman,S. Michael Rothenberg,Ajay Shah,Malgorzata E. Smas,George K. Korir,Frederick P. Floyd,Anna J. Gilman,Jenna B. Lord,Daniel Winokur,Simeon Springer,Daniel Irimia,Daniel Irimia,Sunitha Nagrath,Sunitha Nagrath,Lecia V. Sequist,Lecia V. Sequist,Richard T. Lee,Richard T. Lee,Kurt J. Isselbacher,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber,Mehmet Toner,Mehmet Toner +30 more
TL;DR: A high-throughput microfluidic mixing device, the herringbone-chip, or “HB-Chip,” is described, which provides an enhanced platform for CTC isolation and reveals microclusters of CTCs, previously unappreciated tumor cell aggregates that may contribute to the hematogenous dissemination of cancer.