S
Saroja Somasundaram
Researcher at Allen Institute for Brain Science
Publications - 13
Citations - 1715
Saroja Somasundaram is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Cell type & Biology. The author has an hindex of 7, co-authored 9 publications receiving 777 citations.
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Journal ArticleDOI
Conserved cell types with divergent features in human versus mouse cortex.
Rebecca D. Hodge,Trygve E. Bakken,Jeremy A. Miller,Kimberly A. Smith,Eliza Barkan,Lucas T. Graybuck,Jennie L. Close,Brian Long,Nelson Johansen,Osnat Penn,Zizhen Yao,Jeroen Eggermont,Thomas Höllt,Thomas Höllt,Boaz P. Levi,Soraya I. Shehata,Brian D. Aevermann,Allison Beller,Darren Bertagnolli,Krissy Brouner,Tamara Casper,Charles Cobbs,Rachel A. Dalley,Nick Dee,Songlin Ding,Richard G. Ellenbogen,Olivia Fong,Emma Garren,Jeff Goldy,Ryder P. Gwinn,Daniel Hirschstein,C. Dirk Keene,Mohamed Keshk,Andrew L. Ko,Andrew L. Ko,Kanan Lathia,Ahmed Mahfouz,Ahmed Mahfouz,Zoe Maltzer,Medea McGraw,Thuc Nghi Nguyen,Julie Nyhus,Jeffrey G. Ojemann,Jeffrey G. Ojemann,Aaron Oldre,Sheana Parry,Shannon Reynolds,Christine Rimorin,Nadiya V. Shapovalova,Saroja Somasundaram,Aaron Szafer,Elliot R. Thomsen,Michael Tieu,Gerald Quon,Richard H. Scheuermann,Richard H. Scheuermann,Rafael Yuste,Susan M. Sunkin,Boudewijn P. F. Lelieveldt,Boudewijn P. F. Lelieveldt,David Feng,Lydia Ng,Amy Bernard,Michael Hawrylycz,John W. Phillips,Bosiljka Tasic,Hongkui Zeng,Allan R. Jones,Christof Koch,Ed Lein +69 more
TL;DR: RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.
Journal ArticleDOI
Comparative cellular analysis of motor cortex in human, marmoset and mouse
Trygve E. Bakken,Nikolas L. Jorstad,Qiwen Hu,Blue B. Lake,Wei Tian,Brian E. Kalmbach,Brian E. Kalmbach,Megan Crow,Rebecca D. Hodge,Fenna M. Krienen,Staci A. Sorensen,Jeroen Eggermont,Zizhen Yao,Brian D. Aevermann,Andrew Aldridge,Anna Bartlett,Darren Bertagnolli,Tamara Casper,Rosa Castanon,Kirsten Crichton,Tanya L. Daigle,Rachel A. Dalley,Nick Dee,Nikolai C. Dembrow,Nikolai C. Dembrow,Dinh Diep,Songlin Ding,Weixiu Dong,Rongxin Fang,Stephan Fischer,Melissa Goldman,Jeff Goldy,Lucas T. Graybuck,Brian R. Herb,Xiaomeng Hou,Jayaram Kancherla,Matthew Kroll,Kanan Lathia,Baldur van Lew,Yang Eric Li,Yang Eric Li,Christine S. Liu,Christine S. Liu,Hanqing Liu,Jacinta Lucero,Anup Mahurkar,Delissa McMillen,Jeremy A. Miller,Marmar Moussa,Joseph R. Nery,Philip R. Nicovich,Sheng-Yong Niu,Sheng-Yong Niu,Joshua Orvis,Julia K. Osteen,Scott F. Owen,C. Palmer,C. Palmer,Thanh Pham,Nongluk Plongthongkum,Olivier Poirion,Nora Reed,Christine Rimorin,Angeline Rivkin,William J. Romanow,Adriana E. Sedeno-Cortes,Kimberly Siletti,Saroja Somasundaram,Josef Sulc,Michael Tieu,Amy Torkelson,Herman Tung,Xinxin Wang,Fangming Xie,Anna Marie Yanny,Renee Zhang,Seth A. Ament,M. Margarita Behrens,Héctor Corrada Bravo,Jerold Chun,Alexander Dobin,Jesse Gillis,Ronna Hertzano,Patrick R. Hof,Thomas Höllt,Gregory D. Horwitz,C. Dirk Keene,Peter V. Kharchenko,Andrew L. Ko,Andrew L. Ko,Boudewijn P. F. Lelieveldt,Boudewijn P. F. Lelieveldt,Chongyuan Luo,Eran A. Mukamel,Antonio Pinto-Duarte,Sebastian Preissl,Aviv Regev,Bing Ren,Bing Ren,Richard H. Scheuermann,Richard H. Scheuermann,Richard H. Scheuermann,Kimberly A. Smith,William J. Spain,William J. Spain,Owen White,Christof Koch,Michael Hawrylycz,Bosiljka Tasic,Evan Z. Macosko,Steven A. McCarroll,Steven A. McCarroll,Jonathan T. Ting,Jonathan T. Ting,Hongkui Zeng,Kun Zhang,Guoping Feng,Guoping Feng,Guoping Feng,Joseph R. Ecker,Sten Linnarsson,Ed S. Lein +121 more
TL;DR: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals using high-throughput transcriptomic and epigenomic profiling of more than 450k single nuclei in humans, marmoset monkeys and mice as mentioned in this paper.
Posted ContentDOI
A multimodal cell census and atlas of the mammalian primary motor cortex
Ricky S. Adkins,Andrew Aldridge,Shona Allen,Seth A. Ament,Xu An,Ethan J. Armand,Giorgio A. Ascoli,Trygve E. Bakken,Anita Bandrowski,Samik Banerjee,Nikolaos Barkas,Anna Bartlett,Helen S. Bateup,M. Margarita Behrens,Philipp Berens,Jim Berg,Matteo Bernabucci,Yves Bernaerts,Darren Bertagnolli,Tommaso Biancalani,Lara Boggeman,Sina Booeshaghi,Ian Bowman,Héctor Corrada Bravo,Cathryn R. Cadwell,Edward M. Callaway,Benjamin Carlin,Carolyn O’Connor,Robert A. Carter,Tamara Casper,Rosa Castanon,Jesus Ramon Castro,Rebecca K. Chance,Apaala Chatterjee,Huaming Chen,Jerold Chun,Carlo Colantuoni,Jonathan Crabtree,Heather Huot Creasy,Kirsten Crichton,Megan Crow,Florence D’Orazi,Tanya L. Daigle,Rachel A. Dalley,Nick Dee,Kylee Degatano,Benjamin Dichter,Dinh Diep,Liya Ding,Songlin Ding,Bertha Dominguez,Hong-Wei Dong,Weixiu Dong,Elizabeth L. Dougherty,Sandrine Dudoit,Joseph R. Ecker,Stephen W. Eichhorn,Rongxin Fang,Victor Felix,Guoping Feng,Zhao Feng,Stephan Fischer,Conor Fitzpatrick,Olivia Fong,Nicholas N. Foster,William Galbavy,James C. Gee,Satrajit S. Ghosh,Michelle G. Giglio,Thomas R. Gillespie,Jesse Gillis,Melissa Goldman,Jeff Goldy,Hui Gong,Lin Gou,Michael Grauer,Yaroslav O. Halchenko,Julie M. Harris,Leonard Hartmanis,Joshua T. Hatfield,Michael Hawrylycz,Brian Helba,Brian R. Herb,Ronna Hertzano,Houri Hintiryan,Karla E. Hirokawa,Dirk Hockemeyer,Rebecca D. Hodge,Greg Hood,Gregory D. Horwitz,Xiaomeng Hou,Lijuan Hu,Qiwen Hu,Josh Huang,Bing-Xing Huo,Tony Ito-Cole,Matthew W. Jacobs,Xueyan Jia,Shengdian Jiang,Tao Jiang,Xiaolong Jiang,Xin Jin,Nikolas L. Jorstad,Brian E. Kalmbach,Jayaram Kancherla,C. Dirk Keene,Kathleen Kelly,Farzaneh Khajouei,Peter V. Kharchenko,Gukhan Kim,Andrew L. Ko,Dmitry Kobak,Kishori Konwar,Daniel J. Kramer,Fenna M. Krienen,Matthew Kroll,Xiuli Kuang,Hsien-Chi Kuo,Rachael Larsen,Kanan Lathia,Sophie Laturnus,Angus Y. Lee,Cheng-Ta Lee,Kuo-Fen Lee,Ed S. Lein,Phil Lesnar,Anan Li,Xiangning Li,Xu Li,Yang Eric Li,Yaoyao Li,Yuanyuan Li,Byung Kook Lim,Sten Linnarsson,Christine S. Liu,Hanqing Liu,Lijuan Liu,Jacinta Lucero,Chongyuan Luo,Qingming Luo,Evan Z. Macosko,Anup Mahurkar,Maryann E. Martone,Katherine Matho,Steven A. McCarroll,Carrie McCracken,Delissa McMillen,Elanine Miranda,Partha P. Mitra,Paula Assakura Miyazaki,Judith Mizrachi,Stephanie Mok,Eran A. Mukamel,Shalaka Mulherkar,Naeem Nadaf,Maitham Naeemi,Arun Narasimhan,Joseph R. Nery,Lydia Ng,John Ngai,Thuc Nghi Nguyen,Lance Nickel,Philip R. Nicovich,Sheng-Yong Niu,Vasilis Ntranos,Michael Nunn,Dustin Olley,Joshua Orvis,Julia K. Osteen,Pavel Osten,Scott F. Owen,Lior Pachter,Ramesh Palaniswamy,C. Palmer,Yan Pang,Hanchuan Peng,Thanh Pham,Antonio Pinto-Duarte,Nongluk Plongthongkum,Olivier Poirion,Sebastian Preissl,Elizabeth Purdom,Lei Qu,Mohammad S. Rashid,Nora Reed,Aviv Regev,Bing Ren,Miao Ren,Christine Rimorin,Davide Risso,Angeline Rivkin,Rodrigo Muñoz-Castañeda,William J. Romanow,Alexander J. Ropelewski,Hector Roux de Bézieux,Zongcai Ruan,Rickard Sandberg,Steven Savoia,Federico Scala,Michael Schor,Elise Shen,Kimberly Siletti,Jared B. Smith,Kimberly A. Smith,Saroja Somasundaram,Yuanyuan Song,Staci A. Sorensen,David A. Stafford,Kelly Street,Josef Sulc,Susan M. Sunkin,Valentine Svensson,Pengcheng Tan,Zheng Huan Tan,Bosiljka Tasic,Carol L. Thompson,Wei Tian,Timothy L. Tickle,Michael Tieu,Jonathan T. Ting,Andreas S. Tolias,Amy Torkelson,Herman Tung,Eeshit Dhaval Vaishnav,Koen Van den Berge,Cindy T. J. van Velthoven,Charles R. Vanderburg,Matthew B. Veldman,Minh Vu,Wayne Wakeman,Peng Wang,Quanxin Wang,Xinxin Wang,Yimin Wang,Yun Wang,Joshua D. Welch,Owen White,Elora W Williams,Fangming Xie,Peng Xie,Feng Xiong,William Yang,Anna Marie Yanny,Zizhen Yao,Lulu Yin,Yang Yu,Jing Yuan,Hongkui Z +247 more
TL;DR: This study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps, and establishes a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.
Posted ContentDOI
Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse
Trygve E. Bakken,Nikolas L. Jorstad,Qiwen Hu,Wei Tian,Brian E. Kalmbach,Megan Crow,Rebecca D. Hodge,Fenna M. Krienen,Staci A. Sorensen,Jeroen Eggermont,Zizhen Yao,Brian D. Aevermann,Andrew Aldridge,Anna Bartlett,Darren Bertagnolli,Tamara Casper,Rosa Castanon,Kirsten Crichton,Tanya L. Daigle,Rachel A. Dalley,Nick Dee,Nikolai C. Dembrow,Dinh Diep,Songlin Ding,Weixiu Dong,Rongxin Fang,Stephan Fischer,Melissa Goldman,Jeff Goldy,Lucas T. Graybuck,Brian R. Herb,Xiaomeng Hou,Jayaram Kancherla,Matthew Kroll,Kanan Lathia,Baldur van Lew,Yang Eric Li,Christine S. Liu,Hanqing Liu,Jacinta Lucero,Anup Mahurkar,Delissa McMillen,Jeremy A. Miller,Marmar Moussa,Joseph R. Nery,Philip R. Nicovich,Joshua Orvis,Julia K. Osteen,Scott F. Owen,C. Palmer,Thanh Pham,Nongluk Plongthongkum,Olivier Poirion,Nora Reed,Christine Rimorin,Angeline Rivkin,William J. Romanow,Adriana E. Sedeno-Cortes,Kimberly Siletti,Saroja Somasundaram,Josef Sulc,Michael Tieu,Amy Torkelson,Herman Tung,Xinxin Wang,Fangming Xie,Anna Marie Yanny,Renee Zhang,Seth A. Ament,M. Margarita Behrens,Héctor Corrada Bravo,Jerold Chun,Alexander Dobin,Jesse Gillis,Ronna Hertzano,Patrick R. Hof,Thomas Höllt,Gregory D. Horwitz,Dirk C. Keene,Peter V. Kharchenko,Andrew L. Ko,Boudewijn P. F. Lelieveldt,Chongyuan Luo,Eran A. Mukamel,Sebastian Preissl,Aviv Regev,Bing Ren,Richard H. Scheuermann,Kimberly A. Smith,William J. Spain,Owen White,Christof Koch,Michael Hawrylycz,Bosiljka Tasic,Evan Z. Macosko,Steven A. McCarroll,Jonathan T. Ting,Hongkui Zeng,Kun Zhang,Guoping Feng,Joseph R. Ecker,Sten Linnarsson,Ed Lein +102 more
TL;DR: The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally conserved across mammals, and a broadly conserved cellular makeup is demonstrated, whose similarity mirrors evolutionary distance and is consistent between the transcriptome and epigenome.
Journal ArticleDOI
Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex
John K. Mich,Lucas T. Graybuck,Hess Erik,Joseph T. Mahoney,Yoshiko Kojima,Yi Ding,Saroja Somasundaram,Jeremy A. Miller,Brian E. Kalmbach,Brian E. Kalmbach,Cristina Radaelli,Bryan B. Gore,Natalie Weed,Victoria Omstead,Yemeserach Bishaw,Nadiya V. Shapovalova,Refugio A. Martinez,Olivia Fong,Shenqin Yao,Marty Mortrud,Peter Chong,Luke Loftus,Darren Bertagnolli,Jeff Goldy,Tamara Casper,Nick Dee,Ximena Opitz-Araya,Ali Cetin,Kimberly A. Smith,Ryder P. Gwinn,Charles Cobbs,Andrew L. Ko,Andrew L. Ko,Jeffrey G. Ojemann,Jeffrey G. Ojemann,C. Dirk Keene,Daniel L. Silbergeld,Susan M. Sunkin,Viviana Gradinaru,Gregory D. Horwitz,Hongkui Zeng,Bosiljka Tasic,Ed S. Lein,Ed S. Lein,Ed S. Lein,Jonathan T. Ting,Jonathan T. Ting,Boaz P. Levi +47 more
TL;DR: In this paper, comparative open chromatin analysis was used to identify thousands of human-neocortical-subclass-specific putative enhancers from across the genome to control gene expression in adeno-associated virus (AAV) vectors.