N
Natasha Persaud
Researcher at United States Military Academy
Publications - 7
Citations - 2120
Natasha Persaud is an academic researcher from United States Military Academy. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 6, co-authored 6 publications receiving 2093 citations.
Papers
More filters
Journal ArticleDOI
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity.
John W. Shiver,Tong-Ming Fu,Ling Chen,Danilo R. Casimiro,Mary-Ellen Davies,Robert K. Evans,Zhiqiang Zhang,Adam J. Simon,Wendy L. Trigona,Sheri Dubey,Lingyi Huang,Virginia Harris,Romnie Long,Xiaoping Liang,Larry Handt,William A. Schleif,Lan Zhu,Daniel C. Freed,Natasha Persaud,Liming Guan,Kara Punt,Aimin Tang,Minchun Chen,Keith A. Wilson,Kelly B. Collins,Gwendolyn J. Heidecker,V. Rose Fernandez,Helen C. Perry,Joseph G. Joyce,Karen M. Grimm,James C. Cook,Paul M. Keller,Denise S. Kresock,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,Zheng Xu,Kathryn E. Bohannon,David B. Volkin,David C. Montefiori,Ayako Miura,Georgia R. Krivulka,Michelle A. Lifton,Marcelo J. Kuroda,Jörn E. Schmitz,Norman L. Letvin,Michael J. Caulfield,Andrew J. Bett,Rima Youil,David C. Kaslow,Emilio A. Emini +51 more
TL;DR: The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine and elicited by a replication-incompetent Ad5 vector, used either alone or as a booster inoculation after priming with a DNA vector.
Journal ArticleDOI
Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
Danilo R. Casimiro,Ling Chen,Tong-Ming Fu,Robert K. Evans,Michael J. Caulfield,Mary-Ellen Davies,Aimin Tang,Minchun Chen,Lingyi Huang,Virginia Harris,Daniel C. Freed,Keith A. Wilson,Sheri Dubey,De-Min Zhu,Denise K. Nawrocki,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,William M. Hurni,Zheng Xu,Jeffrey G. Smith,Su Wang,Xu Liu,Liming Guan,Romnie Long,Wendy L. Trigona,Gwendolyn J. Heidecker,Helen C. Perry,Natasha Persaud,Timothy J. Toner,Qin Su,Xiaoping Liang,Rima Youil,Michael Chastain,Andrew J. Bett,David B. Volkin,Emilio A. Emini,John W. Shiver +38 more
TL;DR: Results are suggestive of an immunization strategy for humans that is centered on use of the adenovirus vector and in which existing adenavirus immunity may be overcome by combined immunization with adjuvanted DNA and adenvirus vector boosting.
Journal ArticleDOI
Use of overlapping peptide mixtures as antigens for cytokine flow cytometry
Holden T. Maecker,Holli S Dunn,Maria A. Suni,Elham Khatamzas,Elham Khatamzas,Christine J. Pitcher,Torsten Bunde,Natasha Persaud,Wendy L. Trigona,Tong-Ming Fu,Elizabeth Sinclair,Barry M. Bredt,Joseph M. McCune,Vernon C. Maino,Florian Kern,Louis J. Picker +15 more
TL;DR: Over overlapping 15 amino acid peptide mixes may facilitate the analysis of antigen-specific CD4+ and CD8+ T-cell responses by cytokine flow cytometry, using clinical specimens that include shipped blood or cryopreserved PBMC.
Journal ArticleDOI
Evaluation of Cellular Immune Responses in Subjects Chronically Infected with HIV Type 1
Tong-Ming Fu,Sheri Dubey,Devan V. Mehrotra,Daniel C. Freed,Wendy L. Trigona,Lisa Adams-Muhler,James H. Clair,Thomas G. Evans,Roy T. Steigbigel,Jeffrey M. Jacobson,Paul A. Goepfert,Mark J. Mulligan,Spyros A. Kalams,Charles R. Rinaldo,Lan Zhu,Kara S. Cox,Liming Guan,Romnie Long,Natasha Persaud,Michael J. Caulfield,Jerald C. Sadoff,Emilio A. Emini,Scott Thaler,John W. Shiver +23 more
TL;DR: It is suggested that the high levels of ELISpot responses in chronically infected subjects were reflective of their persistent viral infection, and a positive correlation between host viral loads and ELIS Pot responses of HIV Gag and Pol in untreated subjects was demonstrated.
Journal ArticleDOI
Intracellular Staining for HIV-Specific IFN-γ Production: Statistical Analyses Establish Reproducibility and Criteria for Distinguishing Positive Responses
Wendy L. Trigona,James H. Clair,Natasha Persaud,Kara Punt,Margaret Bachinsky,Usha Sadasivan-Nair,Sheri Dubey,Lynda Tussey,Tong-Ming Fu,John W. Shiver +9 more
TL;DR: The statistical criteria established by these analyses allow for the accurate detection and comparison of positive responses and conclude that the ICS assay is sufficiently robust for use in HIV-specific vaccine trials.