Peter Pickkers

TL;DR: Following CRM implementation in the ED, safety climate improved significantly in three out of six Safety Attitudes Questionnaire domains, both at the end of the implementation and clinical effect years: teamwork climate, safetyClimate, and stress recognition.

TL;DR: The combination of cold exposure training and a breathing exercise most potently attenuates the in vivo inflammatory response in healthy young males and demonstrates that the immunomodulatory effects of the intervention can be reproduced in a standardized manner, thereby paving the way for clinical trials.

TL;DR: Despite considerable differences, experimental endotoxemia captures several long-term aspects of sepsis immunology, specifically the behavior of CD8+ T cells, which may eventually aid the development of new therapies for septic shock patients.

TL;DR: Results indicate that pathways other than the IL-12/IL-18 axis may induce IFN-gamma production in human endotoxemia.

TL;DR: A multilayered omics-based immunoprofiling will provide detailed information to facilitate novel precision immunotherapies in sepsis, and a combination of prognostic and predictive strategies based on serum protein and messenger RNA biomarkers could identify a subgroup of children with septic shock that may be more likely to benefit from corticosteroids.