P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
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Journal ArticleDOI
Patterns in Bacterial- and Viral-Induced Immunosuppression and Secondary Infections in the ICU
Rebecca M. Koch,Matthijs Kox,Marien I. de Jonge,Johannes G. van der Hoeven,Gerben Ferwerda,Peter Pickkers +5 more
TL;DR: The current knowledge on bacterial- and virus-induced immunosuppression and the accompanying susceptibility toward various secondary infections is described and the frequently encountered secondary pathogens and their preferred localizations are presented.
Journal ArticleDOI
Impaired renal function is associated with greater urinary strong ion differences in critically ill patients with metabolic acidosis.
TL;DR: In critically ill patients with metabolic acidosis, impaired renal function was associated with greater urinary SIDs and the higher urinary SID values were related to lower pH levels, illustrating the importance of renal chloride excretion to correct for acidosis.
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Proenkephalin Compared to Conventional Methods to Assess Kidney Function in Critically Ill Sepsis Patients.
TL;DR: GFR appears to be more accurately reflected by plasma PENK concentrations compared to conventional creatinine-based methods, and holds promise as an accurate and feasible biomarker to determine kidney function during non-steady-state conditions in the critically ill.
Journal ArticleDOI
Towards precision medicine for sepsis patients.
Peter Pickkers,Matthijs Kox +1 more
TL;DR: Greater appreciation for the role of the dysregulated immune response is represented in the new definition of sepsis, defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.
Journal ArticleDOI
Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Guus P. Leijte,Hettie Custers,Jelle Gerretsen,Amon Heijne,Johannes Roth,Thomas Vogl,G.J. Scheffer,Peter Pickkers,Matthijs Kox +8 more
TL;DR: CRS-HIPEC is associated with profound DAMP release and immune suppression, and plasma HMGB1 levels are related with the occurrence of postoperative infections in these patients.