P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
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Journal ArticleDOI
Dipyridamole augments the antiinflammatory response during human endotoxemia
Bart P. Ramakers,Niels P. Riksen,Thijmen H Stal,Suzanne Heemskerk,Petra H.H. van den Broek,Wilbert H.M. Peters,Johannes G. van der Hoeven,Paul Smits,Peter Pickkers +8 more
TL;DR: Seven-day oral treatment with dipyridamole increases the circulating adenosine concentration and augments the antiinflammatory response during experimental human endotoxemia, which is associated with a faster decline in proinflammatory cytokines.
Journal ArticleDOI
Effect of organisational factors on the variation in incidence of delirium in intensive care unit patients: A systematic review and meta-regression analysis
Paul J T Rood,Getty Huisman-de Waal,Hester Vermeulen,Lisette Schoonhoven,Peter Pickkers,Mark van den Boogaard +5 more
TL;DR: Systematic review of prospective cohort studies reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement found organisational factors found including methods of delirium assessment, screening frequency, and hospital type were not related to the reported ICUDelirium incidence.
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Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects
Christopher Geven,Dirk van Lier,Alice Blet,Alice Blet,Roel V Peelen,Bas ten Elzen,Alexandre Mebazaa,Alexandre Mebazaa,Matthijs Kox,Peter Pickkers +9 more
TL;DR: The safety, tolerability and pharmacokinetics (PK)/pharmacodynamics of adrecizumab in a first‐in‐man study and in a second study during experimental human endotoxaemia are investigated.
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Epidemiology, risk and prevention of pressure ulcers in critically ill patients: a literature review.
TL;DR: New nursing interventions and pressure-redistributing devices in intensive care units, and specific risk factors affecting critically ill patients, mean that different factors must be taken into consideration in preventing pressure ulcers.
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Continuous administration of enteral lipid- and protein-rich nutrition limits inflammation in a human endotoxemia model.
Tim Lubbers,Matthijs Kox,Jacco-Juri de Haan,Jan Greve,Jan C. Pompe,Bart P. Ramakers,Peter Pickkers,Wim A. Buurman +7 more
TL;DR: Continuous enteral administration of lipid- and protein-rich nutrition is a promising intervention to modulate the immune response in the early course of systemic inflammation in man and enrichment of the nutritional composition with lipid and protein was shown to enhance the anti-inflammatory potential.