P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
Papers
More filters
Journal ArticleDOI
Immunochemical and Mass-Spectrometry–Based Serum Hepcidin Assays for Iron Metabolism Disorders
Joyce J.C. Kroot,Coby M. Laarakkers,Anneke Geurts-Moespot,Nicolai Grebenchtchikov,Peter Pickkers,Annelies E. van Ede,Hilde P.E. Peters,Edmee C. Van Dongen-Lases,Jack F.M. Wetzels,Fred C.G.J. Sweep,Harold Tjalsma,Dorine W. Swinkels +11 more
TL;DR: C-ELISA is the method of choice for the large-scale quantification of serum hepcidin concentrations, because of its low limit of detection, low cost, and high-throughput, and WCX-TOF-MS can be regarded as a valuable special-purpose assay for disorders with variable concentrations of hepcids.
Journal ArticleDOI
Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study.
Jenneke Leentjens,Matthijs Kox,Rebecca M. Koch,Frank Preijers,Leo A. B. Joosten,Johannes G. van der Hoeven,Mihai G. Netea,Peter Pickkers +7 more
TL;DR: It is suggested that IFN-γ is a promising treatment option to reverse sepsis-induced immunoparalysis in vivo in humans.
Journal ArticleDOI
A guide to immunotherapy for COVID-19
Frank L. van de Veerdonk,Evangelos J. Giamarellos-Bourboulis,Peter Pickkers,Lennie P. G. Derde,Helen L. Leavis,Reinout van Crevel,Job J Engel,W. Joost Wiersinga,Alexander P.J. Vlaar,Manu Shankar-Hari,T. van der Poll,Marc J. M. Bonten,Derek C. Angus,Jos W. M. van der Meer,Mihai G. Netea +14 more
TL;DR: In this paper , the authors provide an overview of the evidence generated by major clinical trials of host-directed therapy for patients with COVID-19 and propose an algorithm to guide the use of immunotherapy strategies in the clinic.
Journal ArticleDOI
Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series.
Corine E Delsing,Mark S. Gresnigt,Jenneke Leentjens,Frank Preijers,Florence Frager,Matthijs Kox,Guillaume Monneret,Fabienne Venet,Chantal P. Bleeker-Rovers,Frank L. van de Veerdonk,Peter Pickkers,Alexandre Pachot,Bart Jan Kullberg,Mihai G. Netea +13 more
TL;DR: Evidence is provided that adjunctive immunotherapy with IFN-γ can restore immune function in fungal sepsis patients, warranting future clinical studies to assess its potential clinical benefit.
Journal ArticleDOI
Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans
Matthijs Kox,Lucas T. van Eijk,Jelle Zwaag,Joanne van den Wildenberg,Fred C.G.J. Sweep,Johannes G. van der Hoeven,Peter Pickkers +6 more
TL;DR: It is demonstrated that voluntary activation of the sympathetic nervous system results in epinephrine release and subsequent suppression of the innate immune response in humans in vivo, and could have important implications for the treatment of conditions associated with excessive or persistent inflammation.