P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
Papers
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Journal ArticleDOI
Preclinical safety evaluation of the adrenomedullin-binding antibody Adrecizumab in rodents, dogs and non-human primates.
Christopher Geven,Matthijs Kox,Alice Blet,Alexandre Mebazaa,Mathias Schroedter,Joachim Struck,Andreas Bergmann,Peter Pickkers +7 more
TL;DR: Intravenous, repeated administration of high doses of Adrecizumab appeared well‐tolerated across species and significantly increased circulating concentrations of its target peptide ADM, consistent with previous studies and mechanistically relevant.
Journal ArticleDOI
Mitochondrial DNA and TLR9 Signaling Is Not Involved in Mechanical Ventilation-Induced Inflammation
TL;DR: Mechanical ventilation does not result in the release of mtDNA, and TLR9 is not involved in mechanical ventilation-induced inflammation.
Book ChapterDOI
Endotoxin Tolerance: Mechanisms and Clinical Applicability
TL;DR: Excessive release of pro- and anti-inflammatory cytokines, together with LPS-induced effects on endothelial cells, results in the clinical syndrome of septic shock and multiple organ failure.
Journal ArticleDOI
Alkaline phosphatase treatment improves renal function in patients with severe sepsis or septic shock
Suzanne Heemskerk,Rosalinde Masereeuw,O Moesker,Martijn P.W.J.M. Bouw,J.G. van der Hoeven,Wilbert H.M. Peters,M Velders,Frans G. M. Russel,Peter Pickkers +8 more
TL;DR: In septic patients, infusion of AP results in an attenuated upregulation of iNOS and, subsequent, reduced NO production in the kidney, associated with an improvement in renal function.
Journal ArticleDOI
Circulating biomarkers to assess cardiovascular function in critically ill.
Dirk van Lier,Peter Pickkers +1 more
TL;DR: In this paper, the status of these pathways with circulating biomarkers may provide a unique opportunity to detect specific phenotypes and implement personalized medicine in the treatment of circulatory shock, which is one of the most common reasons for ICU admission.