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Peter Pickkers

Researcher at Radboud University Nijmegen

Publications -  551
Citations -  24686

Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.

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ESICM LIVES 2016: part one

L. J. Bos, +2082 more
TL;DR: Metabonomics identifies early molecular changes associated with progression into postoperative hypoxemia in cardiac surgery patient: a human model that can provide new insights into the pathophysiology of acute lung injury and potentially identify specific biomarkers of lung tissue injury.
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Remote ischaemic preconditioning does not modulate the systemic inflammatory response or renal tubular stress biomarkers after endotoxaemia in healthy human volunteers: a single-centre, mechanistic, randomised controlled trial.

TL;DR: This study investigated whether RIPC affects the response in humans to bacterial endotoxin by measuring plasma cytokines and renal cell-cycle arrest mediators, which reflect renal tubular stress, and found that RIPC neither modulated systemic cytokine release nor attenuated inflammation-induced tubular Stress after LPS.
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The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study.

TL;DR: This adaptive phase 2 clinical study is designed to test the safety and tolerability of EA-230 in patients undergoing cardiac surgery and the effect of the systemic inflammatory response and renal function is investigated.
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Vitamin D status is not associated with inflammatory cytokine levels during experimental human endotoxaemia

TL;DR: Plasma levels of vitamin D are not correlated with the LPS‐induced TNF, IL‐6 and IL‐10 cytokine response in humans in vivo, raising questions about the direct role ofitamin D in modulation of the innate immune response.