P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
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Activation of the ATP-dependent potassium channel attenuates norepinephrine-induced vasoconstriction in the human forearm.
TL;DR: Vasodilation induced by vascular potassium channel activation is associated with an impressive reduction in the vasoconstrictor response to norepinephrine in humans, indicating that potassium channelactivation could account for the diminished nore Pinephrine sensitivity in septic patients.
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Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3.
TL;DR: In this paper, the authors focus on dipeptidyl peptidase 3 (DPP3) and adrenomedullin (ADM), two molecules that act on the vasculature and are involved in the pathophysiology of sepsis and septic shock.
Journal ArticleDOI
The mechanism of action of the adrenomedullin-binding antibody adrecizumab.
Christopher Geven,Peter Pickkers +1 more
TL;DR: Interestingly, animal and human data reveal a strong, dose-dependent increase of plasma ADM concentrations upon adrecizumab infusion, which cannot be explained by increased production of ADM, and a mechanistic explanation for this occurrence was recently proposed.
Journal ArticleDOI
FLOOD: FLow cytometric Orthogonal Orientation for Diagnosis
Jeroen J. Jansen,Bart Hilvering,André van den Doel,Peter Pickkers,Leo Koenderman,Lutgarde M. C. Buydens,Oscar F. van den Brink +6 more
TL;DR: The novel FLow cytometric Orthogonal Orientation for Diagnosis (FLOOD) method reveals disease specific marker patterns and provides new mechanistic insights and confirms established knowledge on LPS-response, which demonstrates the high potential of FLOOD for both clinical and research application.
Journal ArticleDOI
Respiratory Mechanics and Outcomes in Immunocompromised Patients With ARDS A Secondary Analysis of the EFRAIM Study
Alexandre Demoule,Massimo Antonelli,Peter Schellongowski,Peter Pickkers,Marcio Soares,Tine Meyhoff,Jordi Rello,Philippe R. Bauer,Andry Van de Louw,V. Lemiale,David Grimaldi,Ignacio Martin-Loeches,Martin Balik,Sangeeta Mehta,Achille Kouatchet,Andreas Barratt-Due,Miia Valkonen,Jean Reignier,Victoria Metaxa,Anne-Sophie Moreau,Gastón Burghi,Djamel Mokart,Julien Mayaux,Michael Darmon,Elie Azoulay,Karin Amrein,Thomas Staundinger,Gottfried Heinz,Gürkan Sengölge,Christian Zauner,Peter Jaksch,Fabio Silvio Taccone,Anne-Pascale Meert,Dominique Benoit,Ulysses V. A. Silva,Ana Paula Pierre de Moraes,Thiago Lishoa,Jorge I. F. Salluh,William N. Viana,Guilliana Moralez,Thiago Domingos Correa,Umesh Shah,Thomas Karvunidis,Balik Martin,Katerina Russinova,Anders Perner,Tine Sylvest Meyhoff,Nielsen Jonas,Ramin Brandt Bukan,Ann M. Moeller,Lene B. Nielsen,Amélie Seguin,Akli Chermak,Nicolas Terzi,Isabelle Vinatier,Florent Wallet,Kada Klouche,Laura Platon,Benjamin Gaborit,François Barbier,Frédéric Pène,Antoine Rabbat,Virginie Lemiale,Martine Nyunga,Christophe Girault,Caroline Lemaitre,Elise Artaud-Macari,Fabrice Bruneel,Anne Sophie Moreau,Anne Kuitunen,Brian Marsh,Mater Misericordia,Aisling Mc Mahon,Gilda Cinnella,Antonella Cotoia,Ospedali Riuniti,Lucas Montini,Angélique Spoelstra de Man,Precious Pearl Landburg,Dennis C J J Bergmans,Pleun Hemelaar,Thomas Kaufmann,Andreas Barrat-Due,Pål Klepstad,Belen Encina,Gabriel Moreno,Llorenç Socias Crespi,Emilio Rodriguez-Ruiz,Philippe R. Bauer,Yadav Hemang +89 more
TL;DR: In immunocompromised patients with ARDS, respiratory mechanics provide additional prognostic information to predictors of hospital mortality, and studies designed to define lung-protective ventilation guided by these physiological variables may be warranted in this specific population.