P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
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Journal ArticleDOI
Differential antibacterial control by neutrophil subsets.
Pieter H. C. Leliefeld,Janesh Pillay,Nienke Vrisekoop,Marjolein Heeres,Tamar Tak,Matthijs Kox,Suzan H.M. Rooijakkers,Taco W. Kuijpers,Peter Pickkers,Luke P. H. Leenen,Leo Koenderman +10 more
TL;DR: This study provides an evolutionary basis for the rapid release of banded neutrophils into the circulation during acute inflammation and demonstrates a clear neutrophil heterogeneity in their antimicrobial capacity and the appearance of neutrophIL subsets with a clear differentiation in functionality during acuteinflammation.
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Vascular Effects of Adrenomedullin and the Anti-Adrenomedullin Antibody Adrecizumab in Sepsis
TL;DR: A novel hypothesis is provided concerning the mechanisms of action through which Adrecizumab may exert its beneficial effects in sepsis and its effects on endothelial barrier function and vasodilation are described.
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Effort but not Reward Sensitivity is Altered by Acute Sickness Induced by Experimental Endotoxemia in Humans
Amelia Draper,Rebecca M. Koch,J.W.M. van der Meer,M Aj Apps,Peter Pickkers,Masud Husain,M.E. van der Schaaf +6 more
TL;DR: LPS transiently increased interleukin-6 and tumor necrosis factor-α, sickness symptoms, body temperature and self-reported fatigue, and depression post injection relative to baseline and placebo, and it is suggested that LPS-induced changes in motivation may be due to alterations to mesolimbic dopamine.
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Contribution of various metabolites to the "unmeasured" anions in critically ill patients with metabolic acidosis.
Miriam Moviat,Anniek M. Terpstra,Wim Ruitenbeek,Leo A. J. Kluijtmans,Peter Pickkers,Johannes G. van der Hoeven +5 more
TL;DR: Amino acids, uric acid, and organic acids together accounted for only 7.9% of the strong ion gap (SIG), a quantitative measure of “unmeasured” anions, which strongly correlates to the corrected anion gap, in intensive care unit patients with metabolic acidosis.
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Danger in the intensive care unit: damps in critically ill patients.
TL;DR: The role of DAMPs as markers or therapeutic targets in several conditions frequently encountered in critically ill patients, such as sepsis, trauma, ventilator-induced lung injury, and cardiac arrest are discussed.