P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
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Journal ArticleDOI
Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial.
Pierre-François Laterre,Peter Pickkers,Gernot Marx,Xavier Wittebole,Ferhat Meziani,Thierry Dugernier,Vincent Huberlant,Tobias Schuerholz,Bruno François,Jean-Baptiste Lascarrou,Albertus Beishuizen,Haikel Oueslati,Damien Contou,Oscar Hoiting,Jean-Claude Lacherade,Benjamin G. Chousterman,Julien Pottecher,Michael Bauer,Thomas Godet,M. Karakas,Julie Helms,Andreas Bergmann,Jens Zimmermann,Kathleen Richter,Oliver Hartmann,Melanie Pars,Alexandre Mebazaa,AdrenOSS study participants +27 more
TL;DR: This paper investigated safety and tolerability of adrecizumab, a humanized monoclonal adrenomedullin antibody, in septic shock patients with high adrenomedulin.
Journal ArticleDOI
Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients
Evertine J. Abbink,Peter Pickkers,A. Jansen Van Rosendaal,Jos A. Lutterman,C.J.J. Tack,Frans G. M. Russel,Paul Smits +6 more
TL;DR: It is hypothesized that, in contrast to glibenclamide, chronic treatment of Type 2 diabetic patients with glimepiride or metformin will not impair the vasodilator function of KATP opening in vivo.
Journal ArticleDOI
Moderate correlation between systemic IL‐6 responses and CRP with trough concentrations of voriconazole
Bas Vreugdenhil,Walter J.F.M. van der Velden,Ton Feuth,Matthijs Kox,Peter Pickkers,Frank L. van de Veerdonk,Nicole M. A. Blijlevens,Roger J. M. Brüggemann +7 more
TL;DR: It is hypothesized that inflammation has an impact on VCZ pharmacokinetics, and the correlation between VCZ trough concentrations and various cytokines is investigated.
Journal ArticleDOI
Frontline Science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst
Inge Grondman,Rob J.W. Arts,Rebecca M. Koch,Guus P. Leijte,Jelle Gerretsen,Niklas Bruse,Rosalie W. M. Kempkes,Rob ter Horst,Matthijs Kox,Peter Pickkers,Mihai G. Netea,Mihai G. Netea,Mark S. Gresnigt,Mark S. Gresnigt +13 more
TL;DR: It is demonstrated that immunotolerant monocytes are characterized by a loss of metabolic plasticity and these metabolic defects impact antimicrobial monocyte immune functions, and support that the changed cellular metabolism of immunot tolerant monocytes might reveal novel therapeutic targets to reverse sepsis‐induced immunoparalysis.
Journal ArticleDOI
37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3)
V. Karavana,I. Smith,G. Kanellis,I. Sigala,T. Kinsella,S. Zakynthinos,Ling Liu,J. Chen,X. Zhang,Airan Liu,Fengmei Guo,Songqiao Liu,Yi Yang,Haibo Qiu,D. G. Grimaldi,E. Kaya,O. Acicbe,I. Kayaalp,S. Asar,M. Dogan,G. Eren,O. Hergunsel,D. Pavelescu,I. Grintescu,L. Mirea,M. Guanziroli,M. Gotti,Antonella Marino,Massimo Cressoni,G. Vergani,C. Chiurazzi,Davide Chiumello,Luciano Gattinoni,S. Spano,F. Massaro,A. Moustakas,S. Johansson,Anders Larsson,Gaetano Perchiazzi,Xiwen Zhang,Feng Mei Guo,J. X. Chen,M. Xue,Hai Bo Qiu,L. Yang,M. Fister,R. Knafelj,M. A. Suzer,M. E. Kavlak,HK Atalan,Bülent Güçyetmez,Nahit Cakar,D. Weller,A. F. Grootendorst,A. Dijkstra,T. M. Kuijper,B. I. Cleffken,Adrian Regli,B L De Keulenaer,P. V. Van Heerden,D. Hadfield,Phillip A Hopkins,Bethany Penhaligon,Fiona Reid,Nicholas Hart,Gerrard F. Rafferty,Giacomo Grasselli,Tommaso Mauri,Marta Lazzeri,Eleonora Carlesso,B. Cambiaghi,N. Eronia,E. Maffezzini,A. Bronco,Chiara Abbruzzese,N Rossi,Giuseppe Foti,Giacomo Bellani,Antonio Pesenti,G. Li Bassi,M. Panigada,O. R. Ranzani,Theodor Kolobow,A. Zanella,Lorenzo Berra,V. Parrini,H. Kandil,G. Salati,S. Livigni,A. Amatu,Massimo Girardis,M. Barbagallo,G. Moise,G. Mercurio,A. Costa,A. Vezzani,Simone Lindau,J. Babel,M. Cavana,Antoni Torres,O. T. Ranzani,Michele Umbrello,M. Taverna,Paolo Formenti,Giovanni Mistraletti,F. Vetrone,A. Baisi,A. G. Garnero,D. N. Novotni,J. A. Arnal,Martin Urner,Eddy Fan,Martin Dres,S. Vorona,Laurent Brochard,Niall D. Ferguson,Ewan C. Goligher,Czarina C. H. Leung,Gavin M. Joynt,Wai T. Wong,Anna Lee,Charles D. Gomersall,S. Poels,Michael P Casaer,Miet Schetz,G Van den Berghe,Geert Meyfroidt,B. Holzgraefe,L.B. von Kobyletzki,G. Cianchi,F. Becherucci,S. Batacchi,M. Cozzolino,Federico Franchi,S Di Valvasone,M. C. Ferraro,A. Peris,H. Phiphitthanaban,P. Wacharasint,V. Wongsrichanalai,A. Lertamornpong,O. Pengpinij,A. Wattanathum,N. Oer-areemitr,M. Boddi,E. Cappellini,M. Ciapetti,G. Di Lascio,M. Bonizzoli,C. Lazzeri,M. L. Katsin,M. Y. Hurava,A. M. Dzyadzko,Alexander Hermann,Peter Schellongowski,Anja Bojic,Katharina Riss,Oliver Robak,W. Lamm,Wolfgang R. Sperr,Thomas Staudinger,L. Tadini Buoninsegni,J. Parodo,A. Ottaviano,L. Cecci,E. Corsi,V. Ricca,A. Perez Ruiz de Garibay,B. Ende-Schneider,C. Schreiber,B. Kreymann,F Turani,M. Resta,D. Niro,P. Castaldi,G. Boscolo,G. Gonsales,S Martini,Antonio Belli,L. Zamidei,M Falco,T. Lamas,J. Mendes,Alessandro Galazzi,B. Benco,Filippo Binda,L. Masciopinto,A. Lissoni,I. Adamini,T. Thamjamrassri,J. Watcharotayangul,P. Numthavaj,S. Kongsareepong,J. Higuera,David Cabestrero,L. Rey,G. Narváez,A. Blandino,M. Aroca,S. Saéz,R. De Pablo,A. Mohamed,M. Sklar,Laveena Munshi,L. Alban,Cecilia Turrini,Paolo Taccone,C. Marenghi,Savino Spadaro,Carlo Alberto Volta,D. Cabestrero Alonso,L. Rey González,A. Franci,G. Stocchi,G. Cappuccini,F. Socci,C. Guetti,P. Rastrelli,A. Nestorowicz,J. Glapinski,A. Fijalkowska-Nestorowicz,J. Wosko,F. Duprez,T. Bonus,G. Cuvelier,S. Mashayekhi,S. Ollieuz,G. Reychler,I. Kuchyn,K. Bielka,A. Sergienko,H. Jones,C. Day,S. C. Park,S. R. Yeom,Sheila Nainan Myatra,S. Gupta,V. Rajnala,Jigeeshu V Divatia,J. Villalobos Silva,O. Aguilera Olvera,R. Cavazos Schulte,M. Castañeda Bermudez,L. Pariente Zorrilla,H. Lopez Ferretis,K. Trejo García,Neringa Balciuniene,J. Ramsaite,O. Kriukelyte,Asta Krikscionaitiene,Tomas Tamosuitis,P. Terragni,L. Brazzi,D. Falco,L. Pistidda,G. Magni,L. Bartoletti,Luciana Mascia,C. Filippini,Vito Marco Ranieri,A. Kyriakoudi,N. Rovina,O. Koltsida,E. Konstantellou,M. Kardara,E. Kostakou,G. Gavriilidis,I. Vasileiadis,N. Koulouris,A. Koutsoukou,W. Van Snippenburg,A. Kröner,M. Flim,M. Buise,R. Hemler,Peter E. Spronk,B. Noffsinger,Baljit Singh,Lisen Emma Hockings,C. Spina,F. Magni,C. Di Giambattista,Alessia Vargiolu,Giuseppe Citerio,Gaetano Scaramuzzo,A. Waldmann,S. Böhm,Riccardo Ragazzi,C. A. Volta,S. J. Heines,U. Strauch,M. Van de Poll,P. M. Roekaerts,Dennis C J J Bergmans,S. Sosio,Stefano Gatti,V. Punzi,A. Asta,J. Mroczka,AI Yaroshetskiy,N. A. Rezepov,I. Mandel,Gel'fand Br,E. Ozen,E. Karakoc,A. Ayyildiz,S. Kara,S. Ekemen,B Yelken,W. Saasouh,J. Freeman,A. Turan,Z. Hajjej,W. Sellami,M. Bousselmi,W. Samoud,H. Gharsallah,I. Labbene,M. Ferjani,Luigi Vetrugno,F. Barbariol,Francesco Forfori,I. Regeni,G. Della Rocca,Diana Jansen,Annemijn H. Jonkman,Jonne Doorduin,Lisanne H Roesthuis,J.G. van der Hoeven,Leo M. A. Heunks,S. Arrigoni Marocco,M. Bottiroli,R. Pinciroli,V. Galanti,A. Calini,M. Gagliardone,R. Fumagalli,D. Ippolito,V. L. Sala,V. Meroni,M. Elbanna,Y. Nassar,A. Abdelmohsen,M. Yahia,Silvia Mongodi,Francesco Mojoli,Gabriele Via,Guido Tavazzi,F. Fava,Matteo Pozzi,Giorgio Antonio Iotti,Belaid Bouhemad,F. Ruiz-Ferron,J. Serrano Simón,M. Gordillo-Resina,V. Chica-Saez,M I Ruiz García,R. Vela-Colmenero,M. Redondo-Orts,C. Gontijo-Coutinho,T. Ozahata,P. Nocera,D. Franci,Thiago M Santos,Marco Antonio de Carvalho-Filho,O. Fochi,M. Nacoti,D. Signori,D. Bonacina,E. Bonanomi,E. Bonvecchio,Andrea Stella,E. M. Roldi,Anita Orlando,M. Luperto,D. Trunfio,G. Licitra,R. Martinelli,D. Vannini,G. Giuliano,E. Näslund,L. G. Lindberg,I. Lund,Robert Frithiof,A. Nichols,S. Pentakota,B. Kodali,Andrius Pranskunas,I. Kiudulaite,J. Simkiene,D. Damanskyte,Z. Pranskuniene,J. Arstikyte,Dinas Vaitkaitis,Vidas Pilvinis,M. Brazaitis,R. Pool,Håkon Haugaa,A. Botero,D. Escobar,Donald Maberry,Tor Inge Tønnessen,Brian S. Zuckerbraun,Michael R. Pinsky,Hernando Gomez,H. Lyons,A. Trimmings,Roberta Domizi,Claudia Scorcella,Elisa Damiani,Silvia Pierantozzi,Stefania Tondi,Valentina Monaldi,A. Carletti,Samuele Zuccari,Erica Adrario,Paolo Pelaia,Abele Donati,S. Kazune,Andris Grabovskis,K. Volceka,Uldis Rubins,M. Bol,M. Suverein,T. Delnoij,R. Driessen,S. Heines,T. Delhaas,M. Vd Poll,J. Sels,Mathieu Jozwiak,M. Chambaz,P. Sentenac,Christian Richard,Xavier Monnet,Jean-Louis Teboul,Zouheir Ibrahim Bitar,O. Maadarani,R. Al Hamdan,Wolfgang Huber,M. Malbrain,M. Chew,Jihad Mallat,T. Tagami,S. Hundeshagen,Stefan Wolf,S. Mair,Roland M. Schmid,J Aron,M. Adlam,G. Dua,L. Mu,L. C. Chen,Joo Heung Yoon,Gilles Clermont,Artur Dubrawski,Z. Duhailib,K. Al Assas,Azam Shafquat,Nawal Salahuddin,J. Donaghy,P. Morgan,L. Valeanu,M. Stefan,S. Provenchere,Dan Longrois,Andrew D. Shaw,M. G. Mythen,D. Shook,D. Hayashida,S. H. Munson,A. Sawyer,M Mariyaselvam,Mark Blunt,Paul J Young,N. Nakwan,B. Khwannimit,P. Checharoen,David H. Berger,P. Moller,Stefan Bloechlinger,A. Bloch,Stephan M. Jakob,Jukka Takala,J. M. Van den Brule,R. Stolk,E. Vinke,L. M. Van Loon,Peter Pickkers,J.G van der Hoeven,M. Kox,Cornelia W. E. Hoedemaekers,P. Werner-Moller,P. Bertini,Fabio Guarracino,D. Colosimo,S. Gonnella,G. Brizzi,G. Mancino,R. Baldassarri,M. R. Pinsky,D. Amitrano,T. Goslar,D. Stajer,P. Radsel,R. De Vos,N. Bussink-van Dijk,G. Stringari,G. Cogo,A. Devigili,M. Ceola Graziadei,E. Bresadola,P. Lubli,S. Amella,F. Marani,E. Polati,L. Gottin,L. Colinas,G. Hernández,R. Vicho,M. Serna,A. Canabal,R. Cuena,J. Gimenez,Pablo Mercado,François Dépret,K. Sassi,A. Herner,N. Abded,M. Elghonemi,A. Monir,J. Nikhilesh,T. Apurv,A. U. Uber,Anne V. Grossestreuer,Ari Moskowitz,Parth V. Patel,Mathias J Holmberg,Michael W. Donnino,Colin A. Graham,K. Hung,R. Lo,Ling Yan Leung,K. H. Lee,C. Y. Yeung,S. Y. Chan,N.V. Trembach,I.B. Zabolotskikh,J. Caldas,Ronney B. Panerai,L Camara,Gustavo Ferreira,Juliano Pinheiro de Almeida,G. Queiroz de Oliveira,J. Jardim,E. Bor-Seng-Shu,M. R. Lima,R. Nogueira,Fábio Biscegli Jatene,S. P. Zeferino,F Galas,T. G. Robinson,Ludhmila Abrahão Hajjar,MA Oliveira,R. Norgueira,R. Groehs,L. Ferreira-Santos,Gisele Queiroz de Oliveira,L. Hajjar,J Ribeiro,F. Gaiotto,Luis Fernando Lisboa,Julia Tizue Fukushima,Stephanie Itala Rizk,Eduardo A Osawa,Rafael Alves Franco,R. Kalil,M. Chlabicz,B. Sobkowicz,K. Kaminski,R. Kazimierczyk,W. Musial,A. Tycińska,M. Siranovic,A. Gopcevic,Z. G. Gavranovic,A. H. Horvat,H. Krolo,B. Rode,L. Videc,A. Trifi,S. Abdellatif,K. Ben Ismail,A. Bouattour,F. Daly,R Nasri,S Ben Lakhal,Alexandra Beurton,Valentina Girotto,Laura Galarza,T. Guedj,M. Karaman Iliæ,L. Sakic,V. Nn,L. Stojcic,J. Alphonsine,C. Lai,N. Tapanwong,P. Chuntupama,J. Hoellthaler,Tobias Lahmer,H. Latham,C. D. Bengtson,L. Satterwhite,M. Stites,Steven Q. Simpson,T. Skladzien,M. Cicio,J. Garlicki,W. Serednicki,J. Wordliczek,P. Vargas,A. Salazar,M Espinoza,J. Graf,Napplika Kongpolprom,N. Sanguanwong,S. Jonnada,C. Gerrard,Nicola Jones,T. Morley,P. T. Thorburn,T. Musaeva,S. Horst,Miklos Lipcsey,Rafael Kawati,A. Pikwer,J. Rasmusson,Markus Castegren,A. Shilova,A. Yafarova,M. Gilyarov,D. L. Loncar Stojiljkovic,A. Ulici,S. Reidt,T. Lam,J. Jancik,D Ragab,Khaled M. Taema,W. Farouk,M. Saad,Xiaowen Liu,A. Uber,Sophia Montissol,M. W. Donnino,Lars W. Andersen,F. Perlikos,M. Lagiou,A. Papalois,C. Kroupis,I. Toumpoulis,D. Carter,S. Sardo,Giovanni Landoni,S. Kongsayreepong,R. Sungsiri,P. Wongsripunetit,Patricia Marchio,S. Guerra-Ojeda,M. Gimeno-Raga,M. D. Mauricio,Soraya L. Valles,C. Aldasoro,A. Jorda,Martin Aldasoro,Jose Mª Vila,U. B. Borg,A. M. Neitenbach,Manuel Ignacio Monge García,P. Guijo González,M. Gracia Romero,P. Saludes Orduña,A Gil Cano,Andrew Rhodes,R. M. Grounds,Maurizio Cecconi,C. Lee,Feras Hatib,Zhongping Jian,Joseph Rinehart,J. De Los Santos,Cecilia Canales,Maxime Cannesson,M.I. Monge García,Thomas Scheeren,V. Chantziara,A. Vassi,G. Michaloudis,E. Sanidas,S. Golemati,Ryon M. Bateman,A. Mokhtar,W. Omar,K. Abdel Aziz,H. El Azizy,D. L. Lykke Nielsen,Jon Gitz Holler,Annmarie Touborg Lassen,M. Eriksson,G. Strandberg,C. Capoletto,R Nakamura,S. Risk,C Park,F. Dias,N. D’Arrigo,F. Fortuna,S. Redaelli,L. Zerman,L. Becker,T. Serrano,L. Cotes,F. Ramos,L. Fadel,F. Coelho,C. Mendes,J. Real,B. Pedron,M. Kuroki,Eduardo L. V. Costa,L. C. Azevedo +730 more
TL;DR: The results indicate increased metabolism of energy substrates in muscle tissue in experimental sepsis and do not indicate presence of energy depletion or mitochondrial dysfunction in muscle and should similar physiologic situation be present in other tissues, other mechanisms of organ failure must be considered.