P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
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Journal ArticleDOI
Association Between an Increase in Serum Sodium and In-Hospital Mortality in Critically Ill Patients.
Chloe C A Grim,Fabian Termorshuizen,Robert J. Bosman,Olaf L. Cremer,Arend Jan Meinders,Maarten W. N. Nijsten,Peter Pickkers,Angelique M E de Man,Marcus J. Schultz,Peter van Vliet,Joachim D Weigel,Hendrik J F Helmerhorst,Nicolette F. de Keizer,Evert de Jonge +13 more
TL;DR: In this article, a logistic regression model adjusted for age, sex, and Acute Physiology and chronic health evaluation-IV-predicted mortality was used to assess the difference between mean of sodium measurements 24-48 hours after ICU admission and first serum sodium measurement at admission (Δ48 hr]-Na) and in-hospital mortality.
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Higher Dosage of Ciprofloxacin Necessary in Critically Ill Patients: A New Dosing Algorithm Based on Renal Function and Pathogen Susceptibility.
Emilie M Gieling,Emilie M Gieling,Eveline Wallenburg,Tim Frenzel,Dylan W. de Lange,Jeroen Schouten,Jaap ten Oever,Eva Kolwijck,David M. Burger,Peter Pickkers,Rob ter Heine,Roger J. M. Brüggemann +11 more
TL;DR: A new dosing algorithm based on renal function and the MIC of the causative pathogen is provided for ciprofloxacin in critically ill patients to achieve adequate target attainment.
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Phenylephrine impairs host defence mechanisms to infection: a combined laboratory study in mice and translational human study
Roeland F. Stolk,Flavia Naumann,Eva van der Pasch,Joost Schouwstra,Steffi Bressers,Antonius E. van Herwaarden,Jelle Gerretsen,Roel Schambergen,Mike Marvin Ruth,Hans van der Hoeven,Henk J. van Leeuwen,Peter Pickkers,Matthijs Kox +12 more
TL;DR: Phenylephrine infusion increased bacterial counts after caecal ligation and puncture (CLP), while attenuating the release of pro-inflammatory mediators in healthy volunteers as mentioned in this paper.
Journal ArticleDOI
Reply: Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis.
Matthijs Kox,Peter Pickkers +1 more
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Immunomodulatory and Kidney-Protective Effects of the Human Chorionic Gonadotropin Derivate EA-230.
TL;DR: A prospective double-blind placebo-controlled randomized trial in 180 patients undergoing elective CABG-surgery with or without valve surgery is currently conducted to investigate the immunomodulatory and renoprotective properties of EA-230.