Peter Pickkers

TL;DR: A general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues is provided.

TL;DR: The transcriptional and metabolic profiling of human patients with sepsis found that a shift from oxidative phosphorylation to aerobic glycolysis was an important component of initial activation of host defense, and the immunometabolic defects in humans were partially restored by therapy with recombinant interferon-γ, which suggested that metabolic processes might represent a therapeutic target in sepsi.

TL;DR: The most important recent developments in understanding the inflammatory mechanisms of AKI are summarized, key limitations of the commonly used animal models and clinical trial designs that may prevent successful clinical application are highlighted, and priority approaches for research toward clinical translation are suggested.

TL;DR: An integrated epigenomic approach is applied to characterize the molecular events involved in LPS-induced tolerance in a time-dependent manner and reveals that tolerance is reversed at the level of distal element histone modification and transcriptional reactivation of otherwise unresponsive genes.

TL;DR: In this paper, the impact of delirium during intensive care unit stay on long-term health-related quality of life and cognitive function in ICU survivors was examined by using the Short Form-36v1, checklist individual strength-fatigue, and cognitive failure questionnaire.