P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
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Journal ArticleDOI
The Crystal Structure of Lipopolysaccharide Binding Protein Reveals the Location of a Frequent Mutation that Impairs Innate Immunity
Jana Eckert,Young Jong Kim,Jung I. Kim,Kathleen Gürtler,Djin-Ye Oh,Saubashya Sur,Linn Lundvall,Lutz Hamann,Anke van der Ploeg,Peter Pickkers,Evangelos J. Giamarellos-Bourboulis,Andriy V. Kubarenko,Alexander N.R. Weber,Michael Kabesch,Oliver Kumpf,Hyun-Jung An,Jie-Oh Lee,Ralf R. Schumann +17 more
TL;DR: The crystal structure of murine LBP is reported, and the structural integrity of LBP may be crucial for fighting infections efficiently, and future patient stratification might help to develop better therapeutic strategies.
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Implementation of a delirium assessment tool in the ICU can influence haloperidol use.
Mark van den Boogaard,Peter Pickkers,Hans van der Hoeven,Gabriel Roodbol,Theo van Achterberg,Lisette Schoonhoven +5 more
TL;DR: Early detection of delirium in critically ill patients increases the number of patients that receive treatment with haloperidol, however with a lower dose and for a shorter time period.
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GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation.
Matthijs Kox,Jeroen F. van Velzen,Jan C. Pompe,Cornelia W. E. Hoedemaekers,Johannes G. van der Hoeven,Peter Pickkers +5 more
TL;DR: G TS-21 has a profound anti-inflammatory effect in human leukocytes and that GTS-21 is more potent/efficacious than nicotine, which might indicate different pharmacological properties of the alpha7nAChR in humanLeukocytes compared to other cell types.
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Dynamic light application therapy to reduce the incidence and duration of delirium in intensive-care patients: a randomised controlled trial
Koen S. Simons,Koen S. Simons,Robert J. F. Laheij,Mark van den Boogaard,Miriam Moviat,Anne J Paling,Florens Polderman,Frans W. Rozendaal,Geertruda A M Salet,Johannes G. van der Hoeven,Peter Pickkers,Cornelis P.C. de Jager +11 more
TL;DR: DLA as a single intervention does not reduce the cumulative incidence of ICU-acquired delirium and bright-light therapy should be assessed as part of a multicomponent strategy.
Journal ArticleDOI
Reduced rate of intensive care unit acquired gram-negative bacilli after removal of sinks and introduction of ‘water-free’ patient care
Joost Hopman,Alma Tostmann,Heiman F. L. Wertheim,Maria Bos,Eva Kolwijck,Reinier Akkermans,Patrick D. J. Sturm,Andreas Voss,Peter Pickkers,Hans vd Hoeven +9 more
TL;DR: Removal of sinks from patient rooms and introduction of a method of ‘water-free’ patient care is associated with a significant reduction of patient colonization with gram-negative bacilli, especially in patients with a longer ICU length of stay.