P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
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Journal ArticleDOI
The potential of alkaline phosphatase as a treatment for sepsis-associated acute kidney injury.
TL;DR: The renal protective effect of human recombinant alkaline phosphatase in sepsis-associated AKI shall be investigated in a multicenter phase II clinical trial starting at the end of this year.
Journal ArticleDOI
Impact of special patient populations on the pharmacokinetics of echinocandins.
Eline W. Muilwijk,Vincent J. Lempers,David M. Burger,Adilia Warris,Peter Pickkers,Rob E. Aarnoutse,Roger J. M. Brüggemann +6 more
TL;DR: This review provides up-to-date information on PK data of anidulafungin, caspofungin and micaf ungin in special patient populations, including neonates, children and adolescents, obese patients, patients with hepatic or renal impairment, critically ill patients (including burn patients) and patients with hematological diseases.
Journal ArticleDOI
Alkaline Phosphatase as a Treatment of Sepsis-Associated Acute Kidney Injury
Esther Peters,Andrea van Elsas,Suzanne Heemskerk,Jonk Luigi Johannes Cornelius,Johannes G. van der Hoeven,Jacques Arend,Rosalinde Masereeuw,Peter Pickkers +7 more
TL;DR: The clinical activity of AP and its putative molecular modes of action are discussed, and its use to treat and possibly prevent sepsis-associated AKI is speculated on.
Journal ArticleDOI
Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study
Matthijs Kox,Lucas T. van Eijk,Tim Verhaak,Tim Frenzel,Harmke D. Kiers,Jelle Gerretsen,Johannes G. van der Hoeven,Lilian Kornet,Avram Scheiner,Peter Pickkers +9 more
TL;DR: stVNS is feasible and safe, but does not modulate the innate immune response in humans in vivo during experimental human endotoxemia.
Journal ArticleDOI
C1-esterase inhibitor attenuates the inflammatory response during human endotoxemia.
Mirrin J. Dorresteijn,Tjaakje Visser,Laura A. Cox,Martijn P.W.J.M. Bouw,Janesh Pillay,Anky H. L. Koenderman,Paul F. W. Strengers,Luke P. H. Leenen,Johannes G. van der Hoeven,Leo Koenderman,Peter Pickkers +10 more
TL;DR: This study is the first to demonstrate that C1-esterase inhibitor exerts anti-inflammatory effects in the absence of classic complement activation in humans.