R
Richard W. Titball
Researcher at University of Exeter
Publications - 416
Citations - 23987
Richard W. Titball is an academic researcher from University of Exeter. The author has contributed to research in topics: Burkholderia pseudomallei & Clostridium perfringens. The author has an hindex of 79, co-authored 410 publications receiving 22484 citations. Previous affiliations of Richard W. Titball include Imperial College London & United States Army Medical Research Institute of Infectious Diseases.
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Journal ArticleDOI
Genome sequence of Yersinia pestis , the causative agent of plague
Julian Parkhill,Brendan W. Wren,Nicholas R. Thomson,Richard W. Titball,Matthew T. G. Holden,Michael B. Prentice,Mohammed Sebaihia,Keith D. James,Carol Churcher,Karen Mungall,Stephen Baker,D. Basham,Stephen D. Bentley,Karen Brooks,Ana Cerdeño-Tárraga,Tracey Chillingworth,A. Cronin,Robert L. Davies,P. Davis,Gordon Dougan,Theresa Feltwell,N. Hamlin,S. Holroyd,Kay Jagels,Andrey V. Karlyshev,S. Leather,Sharon Moule,P. C. F. Oyston,Michael A. Quail,Kim Rutherford,Mark Simmonds,Jason Skelton,K. Stevens,Sally Whitehead,Bart Barrell +34 more
TL;DR: The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve.
Journal ArticleDOI
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei
Matthew T. G. Holden,Richard W. Titball,Richard W. Titball,Sharon J. Peacock,Sharon J. Peacock,Ana Cerdeño-Tárraga,Timothy P. Atkins,Lisa Crossman,Tyrone Pitt,Carol Churcher,Karen Mungall,Stephen D. Bentley,Mohammed Sebaihia,Nicholas R. Thomson,Nathalie Bason,Ifor R. Beacham,Karen Brooks,Katherine A. Brown,Nat F. Brown,Greg L. Challis,Inna Cherevach,Tracy Chillingworth,Ann Cronin,Ben Crossett,Paul Davis,David DeShazer,Theresa Feltwell,Audrey Fraser,Zahra Hance,Heidi Hauser,S. Holroyd,Kay Jagels,Karen E. Keith,Mark Maddison,Sharon Moule,Claire Price,Michael A. Quail,Ester Rabbinowitsch,Kim Rutherford,Mandy Sanders,Mark Simmonds,Sirirurg Songsivilai,K. Stevens,Sarinna Tumapa,Monkgol Vesaratchavest,Sally Whitehead,Corin Yeats,Bart Barrell,Petra C. F. Oyston,Julian Parkhill +49 more
TL;DR: It is proposed that variable horizontal gene acquisition by B. pseudomallei is an important feature of recent genetic evolution and that this has resulted in a genetically diverse pathogenic species.
Journal ArticleDOI
Tularaemia: bioterrorism defence renews interest in Francisella tularensis
TL;DR: Francisella tularensis is a highly infectious aerosolizable intracellular pathogen that is capable of causing a debilitating or fatal disease with doses as low as 25 colony-forming units, and there is no licensed vaccine available.
Journal ArticleDOI
The complete genome sequence of Francisella tularensis, the causative agent of tularemia.
Pär Larsson,Petra C. F. Oyston,Patrick S. G. Chain,May C. Chu,Melanie Duffield,Hans-Henrik Fuxelius,Emilio Garcia,Greger Hälltorp,Daniel Johansson,Karen E. Isherwood,Peter D. Karp,Eva Larsson,Ying Liu,Stephen L. Michell,Joann L. Prior,Richard G. Prior,Stephanie Malfatti,Anders Sjöstedt,Kerstin Svensson,Nicholas R Thompson,Lisa M. Vergez,Jonathan Wagg,Brendan W. Wren,Luther E. Lindler,Siv G. E. Andersson,Mats Forsman,Richard W. Titball,Richard W. Titball +27 more
TL;DR: The complete genome sequence of a highly virulent isolate of F. tularensis is reported and an unexpectedly high proportion of disrupted pathways are found, explaining the fastidious nutritional requirements of the bacterium.
Journal ArticleDOI
Bacterial phospholipases C.
TL;DR: A greater understanding of the modes of action and structure-function relationships of phospholipases C will facilitate the interpretation of studies in which these enzymes are used as membrane probes and will enhance the use of these proteins as models for eukaryotic phospholIPases C.