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Showing papers by "Roy Thurik published in 2019"


Journal ArticleDOI
Richard Karlsson Linnér1, Richard Karlsson Linnér2, Pietro Biroli3, Edward Kong4, S. Fleur W. Meddens2, S. Fleur W. Meddens1, Robbee Wedow, Mark Alan Fontana5, Mark Alan Fontana6, Maël Lebreton7, Stephen P. Tino8, Abdel Abdellaoui1, Anke R. Hammerschlag1, Michel G. Nivard1, Aysu Okbay1, Cornelius A. Rietveld2, Pascal Timshel9, Pascal Timshel10, Maciej Trzaskowski11, Ronald de Vlaming1, Ronald de Vlaming2, Christian L. Zund3, Yanchun Bao12, Laura Buzdugan3, Laura Buzdugan13, Ann H. Caplin, Chia-Yen Chen14, Chia-Yen Chen4, Peter Eibich15, Peter Eibich16, Peter Eibich17, Pierre Fontanillas, Juan R. González18, Peter K. Joshi19, Ville Karhunen20, Aaron Kleinman, Remy Z. Levin21, Christina M. Lill22, Gerardus A. Meddens, Gerard Muntané18, Gerard Muntané23, Sandra Sanchez-Roige21, Frank J. A. van Rooij2, Erdogan Taskesen1, Yang Wu11, Futao Zhang11, Adam Auton, Jason D. Boardman24, David W. Clark19, Andrew Conlin20, Conor C. Dolan1, Urs Fischbacher25, Patrick J. F. Groenen2, Kathleen Mullan Harris26, Gregor Hasler27, Albert Hofman2, Albert Hofman4, Mohammad Arfan Ikram2, Sonia Jain21, Robert Karlsson28, Ronald C. Kessler4, Maarten Kooyman, James MacKillop29, James MacKillop30, Minna Männikkö20, Carlos Morcillo-Suarez18, Matthew B. McQueen24, Klaus M. Schmidt31, Melissa C. Smart12, Matthias Sutter32, Matthias Sutter33, Matthias Sutter16, Roy Thurik2, André G. Uitterlinden2, Jon White34, Harriet de Wit35, Jian Yang11, Lars Bertram36, Lars Bertram22, Dorret I. Boomsma1, Tõnu Esko37, Ernst Fehr3, David A. Hinds, Magnus Johannesson38, Meena Kumari12, David Laibson4, Patrik K. E. Magnusson28, Michelle N. Meyer39, Arcadi Navarro40, Arcadi Navarro18, Abraham A. Palmer21, Tune H. Pers9, Tune H. Pers10, Danielle Posthuma1, Daniel Schunk41, Murray B. Stein21, Rauli Svento20, Henning Tiemeier2, Paul R. H. J. Timmers19, Patrick Turley14, Patrick Turley42, Patrick Turley4, Robert J. Ursano43, Gert G. Wagner16, Gert G. Wagner17, James F. Wilson44, James F. Wilson19, Jacob Gratten11, Jacob Gratten45, James J. Lee46, David Cesarini47, Daniel J. Benjamin48, Daniel J. Benjamin42, Philipp Koellinger17, Philipp Koellinger1, Jonathan P. Beauchamp8 
TL;DR: This paper found evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of their other GWAS, and general risk-tolerance is genetically correlated with a range of risky behaviors.
Abstract: Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.

395 citations


01 Jan 2019
TL;DR: A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

175 citations


Journal ArticleDOI
TL;DR: In this article, the authors use two waves of the Flash Eurobarometer survey on entrepreneurship (2009 and 2012), which contains information on start-up motivations, startup barriers, and risk perceptions of approximately 3000 (prospective) business owners across 33 countries.
Abstract: Entrepreneurs who start a business to serve both self-interests and collective interests by addressing unmet social and environmental needs are usually referred to as sustainable entrepreneurs. Compared with regular entrepreneurs, we argue that sustainable entrepreneurs face specific challenges when establishing their businesses owing to the discrepancy between the creation and appropriation of private value and social value. We hypothesize that when starting a business, sustainable entrepreneurs (1) feel more hampered by perceived barriers, such as the institutional environment and (2) have a different risk attitude and perception than regular entrepreneurs. We use two waves of the Flash Eurobarometer survey on entrepreneurship (2009 and 2012), which contains information on start-up motivations, start-up barriers, and risk perceptions of approximately 3000 (prospective) business owners across 33 countries. We find that sustainable entrepreneurs indeed perceive more institutional barriers in terms of a lack of financial, administrative, and informational support at business start-up than regular entrepreneurs. Further, no significant differences between sustainable and regular entrepreneurs are found in terms of their risk attitudes or perceived financial risks. However, sustainable entrepreneurs are more likely to fear personal failure than regular entrepreneurs, which is explained by their varied and complex stakeholder relations. These insights may serve as an important signal for both governments and private capital providers in enhancing the institutional climate.

149 citations


Posted ContentDOI
Richard Karlsson Linnér1, Richard Karlsson Linnér2, Pietro Biroli3, Edward Kong4, S. Fleur W. Meddens1, S. Fleur W. Meddens2, Robbee Wedow5, Mark Alan Fontana6, Mark Alan Fontana7, Maël Lebreton8, Abdel Abdellaoui2, Anke R. Hammerschlag2, Michel G. Nivard2, Aysu Okbay2, Cornelius A. Rietveld1, Pascal Timshel9, Pascal Timshel10, Stephen P. Tino11, Maciej Trzaskowski12, Ronald de Vlaming1, Ronald de Vlaming2, Christian L. Zund3, Yanchun Bao13, Laura Buzdugan3, Ann H. Caplin, Chia-Yen Chen4, Chia-Yen Chen14, Peter Eibich15, Peter Eibich16, Peter Eibich17, Pierre Fontanillas, Juan R. González18, Peter K. Joshi19, Ville Karhunen20, Aaron Kleinman, Remy Z. Levin21, Christina M. Lill22, Gerardus A. Meddens, Gerard Muntané18, Sandra Sanchez-Roige21, Frank J. A. van Rooij1, Erdogan Taskesen2, Yang Wu12, Futao Zhang12, Adam Auton, Jason D. Boardman5, David W. Clark19, Andrew Conlin20, Conor C. Dolan2, Urs Fischbacher23, Patrick J. F. Groenen1, Kathleen Mullan Harris24, Gregor Hasler25, Albert Hofman4, Albert Hofman1, Mohammad Arfan Ikram1, Sonia Jain21, Robert Karlsson26, Ronald C. Kessler4, Maarten Kooyman, James MacKillop27, Minna Männikkö20, Carlos Morcillo-Suarez18, Matthew B. McQueen5, Klaus M. Schmidt28, Melissa C. Smart13, Matthias Sutter29, Matthias Sutter15, Roy Thurik1, André G. Uitterlinden1, Jon White30, Harriet de Wit31, Jian Yang12, Lars Bertram32, Lars Bertram22, Dorret I. Boomsma2, Tõnu Esko33, Ernst Fehr3, David A. Hinds, Magnus Johannesson34, Meena Kumari13, David Laibson4, Patrik K. E. Magnusson26, Michelle N. Meyer35, Arcadi Navarro18, Arcadi Navarro36, Abraham A. Palmer21, Tune H. Pers10, Tune H. Pers9, Danielle Posthuma2, Daniel Schunk37, Murray B. Stein21, Rauli Svento20, Henning Tiemeier1, Paul R. H. J. Timmers19, Patrick Turley14, Patrick Turley7, Patrick Turley4, Robert J. Ursano38, Gert G. Wagner15, Gert G. Wagner16, James F. Wilson19, James F. Wilson39, Jacob Gratten12, James J. Lee40, David Cesarini41, Daniel J. Benjamin42, Daniel J. Benjamin6, Daniel J. Benjamin7, Philipp Koellinger16, Philipp Koellinger2, Jonathan P. Beauchamp11 
08 Jan 2019-bioRxiv
TL;DR: Bioinformatics analyses imply that genes near general-risk-tolerance-associated SNPs are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission.
Abstract: Humans vary substantially in their willingness to take risks. In a combined sample of over one million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. We identified 611 approximately independent genetic loci associated with at least one of our phenotypes, including 124 with general risk tolerance. We report evidence of substantial shared genetic influences across general risk tolerance and risky behaviors: 72 of the 124 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is moderately to strongly genetically correlated ( to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near general-risk-tolerance-associated SNPs are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We find no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.

85 citations


Journal ArticleDOI
TL;DR: In this paper, the authors provide a theoretically-empirically aligned test of the connection between the condition of ADHD and entrepreneurial intention and action, and find a positive connection between clinical ADHD with entrepreneurial intentions as well as entrepreneurial action.
Abstract: A growing conversation has emerged linking ostensibly dark or pathological individual-level characteristics to entrepreneurship. Attention deficit/hyperactivity disorder (ADHD) is among the most central and emblematic. Recent studies have made great strides—articulating the theoretical relevance of ADHD-type behavior in entrepreneurship and suggesting a positive link consistent with narratives in the popular press. However, quantitative studies have yet to empirically examine ADHD in line with its theoretical roots and definition—as a clinical disorder. The present paper contributes by providing a theoretically–empirically aligned test of the connection between the condition of ADHD and entrepreneurial intention and action. Based on a large-scale data collection effort (N = 9869) and cross-sectional methodology, the results find a positive connection between clinical ADHD and entrepreneurial intentions as well as entrepreneurial action. This grounds prior research on ADHD and entrepreneurship, indicating that individuals with ADHD are indeed more likely to not just espouse entrepreneurial intentions, but also to initiate business venturing. Considering the design, it suggests a self-selection toward entrepreneurship in individuals with ADHD (before potentially being a choice of last resort).

63 citations


Journal ArticleDOI
TL;DR: A societal and scholarly neglect is identified for the field of small business ownership and health and a research program discriminating between pathogenic and salutogenic effects for a small business owner’s working life is outlined.
Abstract: The present article identifies a societal and scholarly neglect for the field of small business ownership and health. We address health capital and its spillover effects and briefly outline a research program discriminating between pathogenic (negative for health) and salutogenic (positive for health) effects for a small business owner’s working life.

44 citations


Journal ArticleDOI
TL;DR: There was no evidence of significant correlations across the three measurement levels, contradict the outcomes of some previous, smaller studies, which did report significant associations between self-reported impulsivity(-related) measures and behavior and/or electrophysiology.

14 citations


Journal ArticleDOI
01 Jan 2019
TL;DR: In this article, the authors investigate the role of positive affect in entrepreneurial success by using a dataset of more than 800 sole proprietors and find that individuals who express generally positive feelings and emotions are more likely to succeed due to their increased capacity to recognize opportunities, develop broad social networks, respond effectively to rapid change in highly dynamic environments and tolerate intense levels of stress.
Abstract: Despite its widely researched role in individual success in many life domains, there is little evidence of how positive affect (that is, the extent to which an individual subjectively experiences positive feelings and emotions) plays a role in entrepreneurial success. Our study proposes and tests an extended model of Baron’s (2008) conceptual framework to investigate the role of positive affect in entrepreneurial success by using a dataset of more than 800 sole proprietors. Our research model relates positive affect to Baron’s key aspects of the entrepreneurial process (opportunity recognition, financial resource acquisition, social network development, response to dynamic environment, and tolerance to stress) and the entrepreneurial success of sole proprietors. Our findings show that positive affect is indirectly and positively associated with the entrepreneurial success of sole proprietors through this entrepreneurial process. Indeed, sole proprietors who express generally positive feelings and emotions are more likely to succeed due to their increased capacity to recognize opportunities, develop broad social networks, respond effectively to rapid change in highly dynamic environments and tolerate intense levels of stress. Our findings have important implications for theory and practice.

8 citations


Journal ArticleDOI
TL;DR: In this article, the authors propose a set of questions assez generales, mais fondamentales, for the societe entrepreneuriale to solve, which souhaite la decrire et comprendre ses mecanismes, and fixons quelques balises sous forme de propositions.
Abstract: Dans ce bref article, nous motivons l’approfondissement de l’examen de la societe entrepreneuriale en soulevant une serie de questions assez generales, mais fondamentales pour qui souhaite la decrire et comprendre ses mecanismes. Avant d’examiner ces questions, nous fixons quelques balises sous forme de propositions. Nous en retenons deux a savoir, d’une part, l’unite d’observation et les niveaux auxquels se poseraient les enjeux fondamentaux de la societe entrepreneuriale a savoir l’individu et l’interindividualite et, d’autre part, une proposition relative a la place du travail qui y occuperait une place centrale. Les questions soulevees esquissent un programme de recherche de grande ampleur.

5 citations


Journal ArticleDOI
TL;DR: This paper conducts the first empirical dynamic simultaneous equilibrium analysis of the role of entry and exit of firms, the number of firms in an industry, and profit levels in industry dynamics, finding that indeed entrants perform an entrepreneurial function causing long periods of disequilibrium after which a new equilibrium is attained.
Abstract: Entrepreneurial, innovative entry can have devastating effects disrupting a market. However, the many players involved including all current producers, sellers and suppliers and the often non-technological but organizational nature of the innovation may lead to a gradual restoration of the market, viz., to a new equilibrium. Entrepreneurial entry can be regarded as a disaster while the restoration towards a new equilibrium as disaster management. Hardly any empirical models have been developed in order to test these ideas. This paper conducts the first empirical dynamic simultaneous equilibrium analysis of the role of entry and exit of firms, the number of firms in an industry, and profit levels in industry dynamics. Our model enables to discriminate between the entrants’ entrepreneurial function of creating disequilibrium and their conventional role of moving the industry to a new equilibrium. Using a rich data set of the retail industry, we find that indeed entrants perform an entrepreneurial function causing long periods of disequilibrium after which a new equilibrium is attained. Notably, shocks to the entry rate have permanent effects on the industry, emphasizing the entrepreneurial function of entrants rather than their passive reactive function as postulated in classical economics.

3 citations