R
Ryan Zarychanski
Researcher at University of Manitoba
Publications - 230
Citations - 12857
Ryan Zarychanski is an academic researcher from University of Manitoba. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 48, co-authored 193 publications receiving 9665 citations. Previous affiliations of Ryan Zarychanski include Winnipeg Regional Health Authority & McGill University.
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Journal ArticleDOI
Critically ill patients with 2009 influenza A(H1N1) infection in Canada.
Anand Kumar,Ryan Zarychanski,Ruxandra Pinto,Deborah J. Cook,John C. Marshall,Jacques Lacroix,Tom Stelfox,Sean M. Bagshaw,Karen Choong,Francois Lamontagne,Alexis F. Turgeon,Stephen E. Lapinsky,Stéphane P. Ahern,Orla Smith,Faisal Siddiqui,Philippe Jouvet,Kosar Khwaja,Lauralyn McIntyre,Kusum Menon,Jamie Hutchison,David Hornstein,Ari R. Joffe,François Lauzier,Jeffrey M. Singh,Tim Karachi,Kim Wiebe,Kendiss Olafson,Clare D. Ramsey,Sat Sharma,Peter Dodek,Maureen O. Meade,Richard I. Hall,Robert A. Fowler +32 more
TL;DR: Critical illness due to 2009 influenza A(H1N1) in Canada occurred rapidly after hospital admission, often in young adults, and was associated with severe hypoxemia, multisystem organ failure, a requirement for prolonged mechanical ventilation, and the frequent use of rescue therapies.
Journal ArticleDOI
A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19.
David R. Boulware,Matthew F Pullen,Ananta S. Bangdiwala,Katelyn A Pastick,Sarah M Lofgren,Elizabeth C Okafor,Caleb P Skipper,Alanna A Nascene,Melanie R. Nicol,Mahsa Abassi,Nicole W. Engen,Matthew P. Cheng,Derek LaBar,Sylvain A. Lother,Lauren J. MacKenzie,Glen Drobot,Nicole Marten,Ryan Zarychanski,Lauren E. Kelly,Ilan S. Schwartz,Emily G. McDonald,Radha Rajasingham,Todd C. Lee,Kathy H. Hullsiek +23 more
TL;DR: After high-risk or moderate-risk exposure to Covid-19, hydroxychloroquine did not prevent illness compatible with Covid -19 or confirmed infection when used as postexposure prophylaxis within 4 days after exposure.
Journal ArticleDOI
Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
Derek C. Angus,Lennie P. G. Derde,Farah Al-Beidh,Djillali Annane,Yaseen M. Arabi,Abi Beane,Wilma van Bentum-Puijk,Lindsay R. Berry,Zahra Bhimani,Marc J. M. Bonten,Charlotte Bradbury,Frank M. Brunkhorst,Meredith Buxton,Adrian Buzgau,Allen C. Cheng,Menno de Jong,Michelle A. Detry,Lise J Estcourt,Lise J Estcourt,Mark Fitzgerald,Herman Goossens,Cameron Green,Rashan Haniffa,Alisa Higgins,Christopher M. Horvat,Sebastiaan J. Hullegie,Peter Kruger,Francois Lamontagne,Patrick R. Lawler,Kelsey Linstrum,Edward Litton,Elizabeth Lorenzi,John E. A. Marshall,John E. A. Marshall,Daniel F. McAuley,Anna McGlothin,Shay McGuinness,Shay McGuinness,Shay McGuinness,Bryan J. McVerry,Stephanie K. Montgomery,Paul R Mouncey,Srinivas Murthy,Alistair Nichol,Rachael Parke,Rachael Parke,Rachael Parke,Jane Parker,Kathryn M Rowan,Ashish Sanil,Marlene Santos,Christina Saunders,Christopher W. Seymour,Anne Turner,Frank L. van de Veerdonk,Balasubramanian Venkatesh,Balasubramanian Venkatesh,Ryan Zarychanski,Scott M. Berry,Roger J. Lewis,Roger J. Lewis,Colin McArthur,Steven A R Webb,Steven A R Webb,Steven A R Webb,Anthony C. Gordon +65 more
TL;DR: To determine whether hydrocortisone improves outcome for patients with severe COVID-19, an ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin was conducted.
Journal ArticleDOI
Association of Hydroxyethyl Starch Administration With Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation: A Systematic Review and Meta-analysis
Ryan Zarychanski,Ahmed M Abou-Setta,Alexis Turgeon,Brett L. Houston,Lauralyn McIntyre,John C. Marshall,Dean Fergusson +6 more
TL;DR: In critically ill patients requiring acute volume resuscitation, use of hydroxyethyl starch compared with other resuscitation solutions was not associated with a decrease in mortality and clinical use ofHydroxyethyl starch for acuteVolume resuscitation is not warranted due to serious safety concerns.
Journal ArticleDOI
Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19 : A Randomized Trial.
Caleb P Skipper,Katelyn A Pastick,Nicole S Engen,Ananta S Bangdiwala,Mahsa Abassi,Sarah M Lofgren,Darlisha A. Williams,Elizabeth C Okafor,Matthew F Pullen,Melanie R. Nicol,Alanna A Nascene,Katherine Huppler Hullsiek,Matthew P. Cheng,Darlette Luke,Sylvain A. Lother,Lauren J. MacKenzie,Glen Drobot,Lauren E. Kelly,Ilan S. Schwartz,Ryan Zarychanski,Emily G. McDonald,Todd C. Lee,Radha Rajasingham,David R. Boulware +23 more
TL;DR: This randomized, double-blind, placebo-controlled trial evaluated effects of oral hydroxychloroquine on symptoms and disease severity in adult outpatients with early COVID-19.