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Boleslaw Lach
Researcher at McMaster University
Publications - 123
Citations - 8297
Boleslaw Lach is an academic researcher from McMaster University. The author has contributed to research in topics: Myopathy & Meningioma. The author has an hindex of 39, co-authored 121 publications receiving 7390 citations. Previous affiliations of Boleslaw Lach include Polish Academy of Sciences & Ottawa Hospital.
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Journal ArticleDOI
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Paul A. Northcott,Paul A. Northcott,David Shih,John Peacock,Livia Garzia,A. Sorana Morrissy,Thomas Zichner,Adrian M. Stütz,Andrey Korshunov,Jüri Reimand,Steven E. Schumacher,Rameen Beroukhim,Rameen Beroukhim,David W. Ellison,Christian R. Marshall,Anath C. Lionel,Stephen C. Mack,Adrian M. Dubuc,Yuan Yao,Vijay Ramaswamy,Betty Luu,Adi Rolider,Florence M.G. Cavalli,Xin Wang,Marc Remke,Xiaochong Wu,Readman Chiu,Andy Chu,Eric Chuah,Richard Corbett,Gemma Hoad,Shaun D. Jackman,Yisu Li,Allan Lo,Karen Mungall,Ka Ming Nip,Jenny Q. Qian,Anthony Raymond,Nina Thiessen,Richard Varhol,Inanc Birol,Richard A. Moore,Andrew J. Mungall,Robert A. Holt,Daisuke Kawauchi,Martine F. Roussel,Marcel Kool,David T.W. Jones,Hendrick Witt,Africa Fernandez-L,Anna Kenney,Robert J. Wechsler-Reya,Peter B. Dirks,Tzvi Aviv,Wiesława Grajkowska,Marta Perek-Polnik,Christine Haberler,Olivier Delattre,Stéphanie Reynaud,François Doz,Sarah S. Pernet-Fattet,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Wolfram Scheurlen,Charles G. Eberhart,Michelle Fèvre-Montange,Anne Jouvet,Ian F. Pollack,Xing Fan,Karin M. Muraszko,G. Yancey Gillespie,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Nanne K. Kloosterhof,Pim J. French,Johan M. Kros,James M. Olson,Richard G. Ellenbogen,Karel Zitterbart,Leos Kren,Reid C. Thompson,Michael K. Cooper,Boleslaw Lach,Boleslaw Lach,Roger E. McLendon,Darell D. Bigner,Adam M. Fontebasso,Steffen Albrecht,Steffen Albrecht,Nada Jabado,Janet C. Lindsey,Simon Bailey,Nalin Gupta,William A. Weiss,László Bognár,Almos Klekner,Timothy E. Van Meter,Toshihiro Kumabe,Teiji Tominaga,Samer K. Elbabaa,Jeffrey R. Leonard,Joshua B. Rubin,Linda M. Liau,Erwin G. Van Meir,Maryam Fouladi,Hideo Nakamura,Giuseppe Cinalli,Miklós Garami,Peter Hauser,Ali G. Saad,Achille Iolascon,Shin Jung,Carlos Gilberto Carlotti,Rajeev Vibhakar,Young Shin Ra,Shenandoah Robinson,Massimo Zollo,Claudia C. Faria,Jennifer A. Chan,Michael J. Levy,Poul H. Sorensen,Matthew Meyerson,Scott L. Pomeroy,Yoon Jae Cho,Gary D. Bader,Uri Tabori,Cynthia Hawkins,Eric Bouffet,Stephen W. Scherer,James T. Rutka,David Malkin,Steven C. Clifford,Steven J.M. Jones,Jan O. Korbel,Stefan M. Pfister,Stefan M. Pfister,Marco A. Marra,Michael D. Taylor +139 more
TL;DR: Somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas are reported, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Groups 4, which suggest future avenues for rational, targeted therapy.
Journal ArticleDOI
Intertumoral Heterogeneity within Medulloblastoma Subgroups
Florence M.G. Cavalli,Marc Remke,Marc Remke,Marc Remke,Ladislav Rampášek,John Peacock,David Shih,Betty Luu,Livia Garzia,Jonathon Torchia,Carolina Nor,A. Sorana Morrissy,Sameer Agnihotri,Yuan Yao Thompson,Claudia M. Kuzan-Fischer,Hamza Farooq,Keren Isaev,Keren Isaev,Craig Daniels,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Ji Yeoun Lee,Wiesława Grajkowska,Marta Perek-Polnik,Alexandre Vasiljevic,Cécile Faure-Conter,Anne Jouvet,Caterina Giannini,Amulya A. Nageswara Rao,Kay Ka Wai Li,Ho Keung Ng,Charles G. Eberhart,Ian F. Pollack,Ronald L. Hamilton,G. Yancey Gillespie,James M. Olson,James M. Olson,Sarah Leary,William A. Weiss,Boleslaw Lach,Boleslaw Lach,Lola B. Chambless,Reid C. Thompson,Michael K. Cooper,Rajeev Vibhakar,Peter Hauser,Marie Lise C. van Veelen,Johan M. Kros,Pim J. French,Young Shin Ra,Toshihiro Kumabe,Enrique López-Aguilar,Karel Zitterbart,Jaroslav Sterba,Gaetano Finocchiaro,Maura Massimino,Erwin G. Van Meir,Satoru Osuka,Tomoko Shofuda,Almos Klekner,Massimo Zollo,Jeffrey R. Leonard,Joshua B. Rubin,Nada Jabado,Steffen Albrecht,Steffen Albrecht,Jaume Mora,Timothy E. Van Meter,Shin Jung,Andrew S. Moore,Andrew R. Hallahan,Jennifer A. Chan,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti,Maryam Fouladi,José Pimentel,Claudia C. Faria,Ali G. Saad,Luca Massimi,Linda M. Liau,Helen Wheeler,Hideo Nakamura,Samer K. Elbabaa,Mario Perezpeña-Diazconti,Fernando Chico Ponce de León,Shenandoah Robinson,Michal Zapotocky,Alvaro Lassaletta,Annie Huang,Cynthia Hawkins,Uri Tabori,Eric Bouffet,Ute Bartels,Peter B. Dirks,James T. Rutka,Gary D. Bader,Jüri Reimand,Jüri Reimand,Anna Goldenberg,Vijay Ramaswamy,Michael D. Taylor +101 more
TL;DR: Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes.
Journal ArticleDOI
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Stephen C. Mack,Hendrik Witt,Rosario M. Piro,L. Gu,Scott Zuyderduyn,Adrian M. Stütz,Xin Wang,Marco Gallo,Livia Garzia,Kory Zayne,Xiaoyang Zhang,Vijay Ramaswamy,Natalie Jäger,David T.W. Jones,Martin Sill,T. J. Pugh,Marina Ryzhova,Khalida Wani,David Shih,Renee Head,Marc Remke,Swneke D. Bailey,Thomas Zichner,Claudia C. Faria,Mark Barszczyk,Sebastian Stark,Huriye Seker-Cin,Sonja Hutter,Pascal Johann,Sebastian Bender,Volker Hovestadt,Theophilos Tzaridis,Adrian M. Dubuc,Paul A. Northcott,John Peacock,Kelsey C. Bertrand,Sameer Agnihotri,Florence M.G. Cavalli,Ian D. Clarke,K. Nethery-Brokx,Caretha L. Creasy,Sharad K. Verma,Jan Koster,Xiaochong Wu,Yuan Yao,Till Milde,Patrick Sin-Chan,Jennifer Zuccaro,Loretta Lau,Sergio L. Pereira,Pedro Castelo-Branco,Martin Hirst,Marco A. Marra,Stephen S. Roberts,Daniel W. Fults,Luca Massimi,Yoon Jae Cho,T. Van Meter,Wiesława Grajkowska,Boleslaw Lach,Andreas E. Kulozik,A. von Deimling,Olaf Witt,Stephen W. Scherer,Xing Fan,Karin M. Muraszko,Marcel Kool,Scott L. Pomeroy,Nalin Gupta,Joanna J. Phillips,Annie Huang,Uri Tabori,Cynthia Hawkins,David Malkin,Paul Kongkham,William A. Weiss,Nada Jabado,James T. Rutka,Eric Bouffet,Jan O. Korbel,Mathieu Lupien,Kenneth Aldape,Gary D. Bader,Roland Eils,Peter Lichter,Peter B. Dirks,Stefan M. Pfister,Andrey Korshunov,Michael D. Taylor +88 more
TL;DR: It is concluded that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland.
Journal ArticleDOI
Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma
Hendrik Witt,Stephen C. Mack,Marina Ryzhova,Sebastian Bender,Sebastian Bender,Martin Sill,Ruth Isserlin,Axel Benner,Thomas Hielscher,Till Milde,Till Milde,Marc Remke,Marc Remke,David T.W. Jones,Paul A. Northcott,Livia Garzia,Kelsey C. Bertrand,Andrea Wittmann,Yuan Yao,Stephen S. Roberts,Luca Massimi,Tim Van Meter,William A. Weiss,Nalin Gupta,Wiesia Grajkowska,Boleslaw Lach,Yoon Jae Cho,Andreas von Deimling,Andreas von Deimling,Andreas E. Kulozik,Olaf Witt,Olaf Witt,Gary D. Bader,Cynthia Hawkins,Uri Tabori,Abhijit Guha,James T. Rutka,Peter Lichter,Andrey Korshunov,Andrey Korshunov,Michael D. Taylor,Stefan M. Pfister,Stefan M. Pfister +42 more
TL;DR: Identification and optimization of immunohistochemical (IHC) markers for PF ependymoma subgroups allowed validation of the findings on a third independent cohort, using a human ependyoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependedymoma patients.
Journal ArticleDOI
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
Paul A. Northcott,Yukiko Nakahara,Xiaochong Wu,Lars Feuk,David W. Ellison,Sid Croul,Stephen C. Mack,Paul Kongkham,John Peacock,Adrian M. Dubuc,Young Shin Ra,Karen Zilberberg,Jessica McLeod,Stephen W. Scherer,J. Sunil Rao,Charles G. Eberhart,Wiesia Grajkowska,Yancey Gillespie,Boleslaw Lach,Richard Grundy,Ian F. Pollack,Ronald L. Hamilton,Timothy E. Van Meter,Carlos Gilberto Carlotti,Frederick A. Boop,Darrell D. Bigner,Richard J. Gilbertson,James T. Rutka,Michael D. Taylor +28 more
TL;DR: Copy number aberrations of genes with critical roles in writing, reading, removing and blocking the state of histone lysine methylation, particularly at H3K9, suggest that defective control of the histone code contributes to the pathogenesis of medulloblastoma.