Y
Yuan Yao
Researcher at University of Toronto
Publications - 6
Citations - 1967
Yuan Yao is an academic researcher from University of Toronto. The author has contributed to research in topics: Ependymoma & Pediatric ependymoma. The author has an hindex of 6, co-authored 6 publications receiving 1728 citations.
Papers
More filters
Journal ArticleDOI
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Paul A. Northcott,Paul A. Northcott,David Shih,John Peacock,Livia Garzia,A. Sorana Morrissy,Thomas Zichner,Adrian M. Stütz,Andrey Korshunov,Jüri Reimand,Steven E. Schumacher,Rameen Beroukhim,Rameen Beroukhim,David W. Ellison,Christian R. Marshall,Anath C. Lionel,Stephen C. Mack,Adrian M. Dubuc,Yuan Yao,Vijay Ramaswamy,Betty Luu,Adi Rolider,Florence M.G. Cavalli,Xin Wang,Marc Remke,Xiaochong Wu,Readman Chiu,Andy Chu,Eric Chuah,Richard Corbett,Gemma Hoad,Shaun D. Jackman,Yisu Li,Allan Lo,Karen Mungall,Ka Ming Nip,Jenny Q. Qian,Anthony Raymond,Nina Thiessen,Richard Varhol,Inanc Birol,Richard A. Moore,Andrew J. Mungall,Robert A. Holt,Daisuke Kawauchi,Martine F. Roussel,Marcel Kool,David T.W. Jones,Hendrick Witt,Africa Fernandez-L,Anna Kenney,Robert J. Wechsler-Reya,Peter B. Dirks,Tzvi Aviv,Wiesława Grajkowska,Marta Perek-Polnik,Christine Haberler,Olivier Delattre,Stéphanie Reynaud,François Doz,Sarah S. Pernet-Fattet,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Wolfram Scheurlen,Charles G. Eberhart,Michelle Fèvre-Montange,Anne Jouvet,Ian F. Pollack,Xing Fan,Karin M. Muraszko,G. Yancey Gillespie,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Nanne K. Kloosterhof,Pim J. French,Johan M. Kros,James M. Olson,Richard G. Ellenbogen,Karel Zitterbart,Leos Kren,Reid C. Thompson,Michael K. Cooper,Boleslaw Lach,Boleslaw Lach,Roger E. McLendon,Darell D. Bigner,Adam M. Fontebasso,Steffen Albrecht,Steffen Albrecht,Nada Jabado,Janet C. Lindsey,Simon Bailey,Nalin Gupta,William A. Weiss,László Bognár,Almos Klekner,Timothy E. Van Meter,Toshihiro Kumabe,Teiji Tominaga,Samer K. Elbabaa,Jeffrey R. Leonard,Joshua B. Rubin,Linda M. Liau,Erwin G. Van Meir,Maryam Fouladi,Hideo Nakamura,Giuseppe Cinalli,Miklós Garami,Peter Hauser,Ali G. Saad,Achille Iolascon,Shin Jung,Carlos Gilberto Carlotti,Rajeev Vibhakar,Young Shin Ra,Shenandoah Robinson,Massimo Zollo,Claudia C. Faria,Jennifer A. Chan,Michael J. Levy,Poul H. Sorensen,Matthew Meyerson,Scott L. Pomeroy,Yoon Jae Cho,Gary D. Bader,Uri Tabori,Cynthia Hawkins,Eric Bouffet,Stephen W. Scherer,James T. Rutka,David Malkin,Steven C. Clifford,Steven J.M. Jones,Jan O. Korbel,Stefan M. Pfister,Stefan M. Pfister,Marco A. Marra,Michael D. Taylor +139 more
TL;DR: Somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas are reported, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Groups 4, which suggest future avenues for rational, targeted therapy.
Journal ArticleDOI
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Stephen C. Mack,Hendrik Witt,Rosario M. Piro,L. Gu,Scott Zuyderduyn,Adrian M. Stütz,Xin Wang,Marco Gallo,Livia Garzia,Kory Zayne,Xiaoyang Zhang,Vijay Ramaswamy,Natalie Jäger,David T.W. Jones,Martin Sill,T. J. Pugh,Marina Ryzhova,Khalida Wani,David Shih,Renee Head,Marc Remke,Swneke D. Bailey,Thomas Zichner,Claudia C. Faria,Mark Barszczyk,Sebastian Stark,Huriye Seker-Cin,Sonja Hutter,Pascal Johann,Sebastian Bender,Volker Hovestadt,Theophilos Tzaridis,Adrian M. Dubuc,Paul A. Northcott,John Peacock,Kelsey C. Bertrand,Sameer Agnihotri,Florence M.G. Cavalli,Ian D. Clarke,K. Nethery-Brokx,Caretha L. Creasy,Sharad K. Verma,Jan Koster,Xiaochong Wu,Yuan Yao,Till Milde,Patrick Sin-Chan,Jennifer Zuccaro,Loretta Lau,Sergio L. Pereira,Pedro Castelo-Branco,Martin Hirst,Marco A. Marra,Stephen S. Roberts,Daniel W. Fults,Luca Massimi,Yoon Jae Cho,T. Van Meter,Wiesława Grajkowska,Boleslaw Lach,Andreas E. Kulozik,A. von Deimling,Olaf Witt,Stephen W. Scherer,Xing Fan,Karin M. Muraszko,Marcel Kool,Scott L. Pomeroy,Nalin Gupta,Joanna J. Phillips,Annie Huang,Uri Tabori,Cynthia Hawkins,David Malkin,Paul Kongkham,William A. Weiss,Nada Jabado,James T. Rutka,Eric Bouffet,Jan O. Korbel,Mathieu Lupien,Kenneth Aldape,Gary D. Bader,Roland Eils,Peter Lichter,Peter B. Dirks,Stefan M. Pfister,Andrey Korshunov,Michael D. Taylor +88 more
TL;DR: It is concluded that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland.
Journal ArticleDOI
Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma
Hendrik Witt,Stephen C. Mack,Marina Ryzhova,Sebastian Bender,Sebastian Bender,Martin Sill,Ruth Isserlin,Axel Benner,Thomas Hielscher,Till Milde,Till Milde,Marc Remke,Marc Remke,David T.W. Jones,Paul A. Northcott,Livia Garzia,Kelsey C. Bertrand,Andrea Wittmann,Yuan Yao,Stephen S. Roberts,Luca Massimi,Tim Van Meter,William A. Weiss,Nalin Gupta,Wiesia Grajkowska,Boleslaw Lach,Yoon Jae Cho,Andreas von Deimling,Andreas von Deimling,Andreas E. Kulozik,Olaf Witt,Olaf Witt,Gary D. Bader,Cynthia Hawkins,Uri Tabori,Abhijit Guha,James T. Rutka,Peter Lichter,Andrey Korshunov,Andrey Korshunov,Michael D. Taylor,Stefan M. Pfister,Stefan M. Pfister +42 more
TL;DR: Identification and optimization of immunohistochemical (IHC) markers for PF ependymoma subgroups allowed validation of the findings on a third independent cohort, using a human ependyoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependedymoma patients.
Journal ArticleDOI
Cytogenetic Prognostication Within Medulloblastoma Subgroups
David Shih,Paul A. Northcott,Marc Remke,Andrey Korshunov,Vijay Ramaswamy,Marcel Kool,Betty Luu,Yuan Yao,Xin Wang,Adrian M. Dubuc,Livia Garzia,John Peacock,Stephen C. Mack,Xiaochong Wu,Adi Rolider,A. Sorana Morrissy,Florence M.G. Cavalli,David T.W. Jones,Karel Zitterbart,Claudia C. Faria,Claudia C. Faria,Ulrich Schüller,Leos Kren,Toshihiro Kumabe,Teiji Tominaga,Young Shin Ra,Miklós Garami,Peter Hauser,Jennifer A. Chan,Shenandoah Robinson,László Bognár,Almos Klekner,Ali G. Saad,Linda M. Liau,Steffen Albrecht,Adam M. Fontebasso,Giuseppe Cinalli,Pasqualino De Antonellis,Massimo Zollo,Michael K. Cooper,Reid C. Thompson,Simon Bailey,Janet C. Lindsey,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Stephen W. Scherer,Joanna J. Phillips,Nalin Gupta,Xing Fan,Karin M. Muraszko,Rajeev Vibhakar,Charles G. Eberhart,Maryam Fouladi,Boleslaw Lach,Shin Jung,Robert J. Wechsler-Reya,Michelle Fèvre-Montange,Anne Jouvet,Nada Jabado,Ian F. Pollack,William A. Weiss,Ji Yeoun Lee,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Jeffrey R. Leonard,Joshua B. Rubin,Carmen de Torres,Cinzia Lavarino,Jaume Mora,Yoon Jae Cho,Uri Tabori,James M. Olson,Amar Gajjar,Roger J. Packer,Stefan Rutkowski,Scott L. Pomeroy,Pim J. French,Nanne K. Kloosterhof,Johan M. Kros,Erwin G. Van Meir,Steven C. Clifford,Franck Bourdeaut,Olivier Delattre,François Doz,François Doz,Cynthia Hawkins,David Malkin,Wiesława Grajkowska,Marta Perek-Polnik,Eric Bouffet,James T. Rutka,Stefan M. Pfister,Stefan M. Pfister,Michael D. Taylor +95 more
TL;DR: A small panel of cytogenetic biomarkers is identified that reliably identifies very high-risk and very low-risk groups of patients, making it an excellent tool for selecting patients for therapy intensification and therapy de-escalation in future clinical trials.
Journal ArticleDOI
Molecular genetics of ependymoma
TL;DR: This review summarizes the current knowledge in the molecular genetics of ependymoma and proposes future research directions necessary to further advance this field.