S
Serpil C. Erzurum
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 406
Citations - 34734
Serpil C. Erzurum is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 87, co-authored 353 publications receiving 29654 citations. Previous affiliations of Serpil C. Erzurum include Pulmonary Vascular Research Institute & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Pro-angiogenic hematopoietic progenitor cells and endothelial colony-forming cells in pathological angiogenesis of bronchial and pulmonary circulation
TL;DR: Current knowledge of pro-angiogenic progenitor cells in the pathogenesis of asthma and PAH is reviewed to establish an environment that favors angiogenesis in physiologic and pathophysiologic responses.
Journal ArticleDOI
Inhibition of Tumor Necrosis Factor α for Refractory Asthma
TL;DR: Tumor necrosis factor, originally discovered and named on the basis of its tumor regression activity, is an important cytokine that regulates the pathogenetic mechanisms of chronic inflammato...
Journal ArticleDOI
Nitric oxide regulation of asthmatic airway inflammation with segmental allergen challenge.
Mary Jane Thomassen,Baisakhi Raychaudhuri,Raed A. Dweik,Carol Farver,Lisa T. Buhrow,Anagha Malur,Mary J. Connors,Judy Drazba,Jeffrey P. Hammel,Serpil C. Erzurum,Mani S. Kavuru +10 more
TL;DR: It is proposed that NO that is up-regulated by cytokines is part of an autoregulatory feedback loop (ie, allergen challenge stimulates inflammatory cytokine production, which in turn stimulates NO production, and NO down-regulates cytokineProduction) in allergic asthmatic patients.
Journal ArticleDOI
Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension
Fei Liu,Christina Mallarino Haeger,Paul B. Dieffenbach,Delphine Sicard,Izabela Chrobak,Anna Coronata,Margarita M. Suarez Velandia,Sally H. Vitali,Romain A. Colas,Paul C. Norris,Aleksandar Marinkovic,Xiaoli Liu,Jun Ma,Chase D. Rose,Seon-Jin Lee,Suzy A.A. Comhair,Serpil C. Erzurum,Jacob D. McDonald,Charles N. Serhan,Stephen R. Walsh,Daniel J. Tschumperlin,Laura E. Fredenburgh +21 more
TL;DR: It is shown that distal vascular matrix stiffening is an early mechanobiological regulator of experimental PH and cyclooxygenase-2 suppression and corresponding reduction in prostaglandin production as pivotal regulators of stiffness-dependent vascular cell activation.
Journal ArticleDOI
Alterations in exhaled gas profile during allergen-induced asthmatic response.
Sumita Khatri,Metri Özkan,Kevin McCarthy,Daniel Laskowski,Jeffrey P. Hammel,Raed A. Dweik,Serpil C. Erzurum +6 more
TL;DR: Exhaled CO of asthmatics was not higher than that of control individuals at baseline, decreased immediately after allergen, and returned to baseline levels during the late asthmatic response, indicating that allergenic-induced airway inflammation did not lead to increased exhaled CO in asthma.