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Serpil C. Erzurum

Researcher at Cleveland Clinic Lerner Research Institute

Publications -  406
Citations -  34734

Serpil C. Erzurum is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 87, co-authored 353 publications receiving 29654 citations. Previous affiliations of Serpil C. Erzurum include Pulmonary Vascular Research Institute & National Institutes of Health.

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An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling.

Arnab Ghosh, +6 more
- 01 Feb 2021 - 
TL;DR: This work reveals that severe asthmatics are predisposed toward defective NO-sGC-cGMP signaling in their airway smooth muscle due to an inherent sGC dysfunction, which in turn is associated with inherent changes in the cell redox enzymes that impact sGC maturation and function.
Journal ArticleDOI

Modulation of Asthma Pathogenesis by Nitric Oxide Pathways and Therapeutic Opportunities.

Sudakshina Ghosh, +2 more
- 01 Dec 2012 - 
TL;DR: The role of NO is discussed with the primary focus on therapeutic opportunities developed in recent years, and the development of compounds that target NO metabolic pathways, and provide opportunities for novel asthma therapy.

Constitutive Expression of the Catalase Gene in Human Bronchial Epithelial Cells Despite Oxidant Stress

Jee-Hong Yoo, +5 more
TL;DR: Levels of catalase were significantly increased in human airway epithelial cells and this was associated with increased survival of the cells when exposed to hyperoxia, providing a basis for understanding the sensitivity of the humanAirway epithelium to oxidant stress and a strategy for protecting the epithelia from such injury.
Journal ArticleDOI

Can the Electronic Nose Really Sniff out Lung Cancer

Serpil C. Erzurum, +10 more
- 15 Oct 2005 - 
Journal ArticleDOI

Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

Usman A. Tahir, +428 more
- 22 Aug 2022 - 
TL;DR: The authors performed a whole genome association study of 2,291 metabolite peaks (known and unknown features) in 2,466 Black individuals from the Jackson Heart Study and identified 519 locus-metabolite associations for 427 metabolites and validated their findings in two multi-ethnic cohorts.