S
Serpil C. Erzurum
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 406
Citations - 34734
Serpil C. Erzurum is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 87, co-authored 353 publications receiving 29654 citations. Previous affiliations of Serpil C. Erzurum include Pulmonary Vascular Research Institute & National Institutes of Health.
Papers
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Journal ArticleDOI
Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma.
Xingnan Li,Annette T. Hastie,Michael C. Peters,Gregory A. Hawkins,Wanda Phipatanakul,Huashi Li,Wendy C. Moore,William W. Busse,Mario Castro,Serpil C. Erzurum,Benjamin Gaston,Elliot Israel,Nizar N. Jarjour,Bruce D. Levy,Sally E. Wenzel,Deborah A. Meyers,John V. Fahy,Eugene R. Bleecker +17 more
TL;DR: Combination of IL-6 and FeNO or blood eosinophil count identified asthma endotypes related to asthma severity, exacerbations, and responsiveness to corticosteroids and potential for response to anti-Type 2 and anti-IL-6 treatment.
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Disulfide Bond As a Switch for Copper-Zinc Superoxide Dismutase Activity in Asthma
Sudakshina Ghosh,Belinda Willard,Suzy A.A. Comhair,Patricia M. DiBello,Weiling Xu,Sruti Shiva,Kulwant S. Aulak,Michael Kinter,Serpil C. Erzurum +8 more
TL;DR: This study identifies a new paradigm for understanding the chemical basis of inflammation, in which redox regulation of thiol availability dictates protein susceptibility to environmental and endogenously generated reactive species.
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A novel p38 mitogen-activated protein kinase/Elk-1 transcription factor-dependent molecular mechanism underlying abnormal endothelial cell proliferation in plexogenic pulmonary arterial hypertension.
Monal Patel,Dan Predescu,Rajive Tandon,Cristina Bardita,Jennifer Pogoriler,Sangeeta Bhorade,Minhua Wang,Suzy A.A. Comhair,Anna Ryan-Hemnes,Jiwang Chen,Roberto Machado,Aliya N. Husain,Serpil C. Erzurum,Sanda Predescu +13 more
TL;DR: A novel GrB-EHITSN-dependent pathogenic p38MAPK/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH is identified.
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A novel method for pulmonary research: Assessment of bioenergetic function at the air–liquid interface
Weiling Xu,Allison J. Janocha,Rachel Leahy,Ryan S. Klatte,Dave Dudzinski,Lori Mavrakis,Suzy A.A. Comhair,Mark E. Lauer,Calvin U. Cotton,Serpil C. Erzurum,Serpil C. Erzurum +10 more
TL;DR: An insert was engineered for the Seahorse XF24 Analyzer that enabled the measure of respiration by oxygen consumption rate (OCR) and glycolysis by extracellular acidification rate (ECAR) andOxidative metabolism and glyCOlysis in airway epithelial cells cultured on the inserts were successfully measured.
Journal ArticleDOI
Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension.
TL;DR: Results indicate that generally both receptors are reduced in PAH particularly ETB, and that ETB signaling through protein kinases becomes markedly reduced in BMPR2 PASMC, while it continues in IPAH, and suggest that caution must be taken when applying ET‐1 receptor antagonist therapy to PAH patients.