S
Serpil C. Erzurum
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 406
Citations - 34734
Serpil C. Erzurum is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 87, co-authored 353 publications receiving 29654 citations. Previous affiliations of Serpil C. Erzurum include Pulmonary Vascular Research Institute & National Institutes of Health.
Papers
More filters
Journal Article
Differential Expression of Manganese Superoxide Dismutase and Catalase in Lung Cancer
TL;DR: In this article, the authors investigated the role of manganese superoxide dismutase (SOD), catalase, and glutathione peroxidase in lung cancer development.
Journal ArticleDOI
Eosinophils Are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species
Jennifer C. MacPherson,Suzy A.A. Comhair,Serpil C. Erzurum,Dennis F. Klein,Mary F. Lipscomb,Mani S. Kavuru,Michael Samoszuk,Stanley L. Hazen,Stanley L. Hazen +8 more
TL;DR: It is demonstrated that eosinophils use distinct mechanisms for generating NO-derived oxidants and EPO as an enzymatic source of nitrating intermediates in eos inophils at low, but not high, rates of NO flux, EPO inhibitors and catalase markedly attenuated aromatic nitration.
Journal ArticleDOI
Use of Exhaled Nitric Oxide Measurement to Identify a Reactive, at-Risk Phenotype among Patients with Asthma
Raed A. Dweik,Raed A. Dweik,R.L. Sorkness,Sally E. Wenzel,Jeffrey P. Hammel,Douglas Curran-Everett,Suzy A. A. Comhair,Suzy A. A. Comhair,Eugene R. Bleecker,William W. Busse,William J. Calhoun,Mario Castro,Kian Fan Chung,Elliot Israel,Nizar N. Jarjour,Wendy C. Moore,Stephen P. Peters,Gerald Teague,Benjamin Gaston,Serpil C. Erzurum,Serpil C. Erzurum +20 more
TL;DR: Grouping of asthma by Fe(NO) provides an independent classification of asthma severity, and among patients with severe asthma identifies the most reactive and worrisome asthma phenotype.
Journal ArticleDOI
Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis.
Fuhua H. Guo,Suzy A. A. Comhair,Shuo Zheng,Raed A. Dweik,N. Tony Eissa,Mary Jane Thomassen,William J. Calhoun,Serpil C. Erzurum +7 more
TL;DR: Two studies define multiple mechanisms that function coordinately to support high level NO synthesis in the asthmatic airway and nitration of proteins in airway epithelium provide evidence of functional consequences of increased NO.
Journal ArticleDOI
Human vascular endothelial cells express oxytocin receptors.
Marc Thibonnier,Doreen M. Conarty,Judy A. Preston,Christine L. Plesnicher,Raed A. Dweik,Serpil C. Erzurum +5 more
TL;DR: Human vascular ECs express OT receptors that are structurally identical to the uterine and mammary OT receptors, and these endothelial OT receptors produce a calcium-dependent vasodilatory response via stimulation of the nitric oxide pathway and have a trophic action.