S
Serpil C. Erzurum
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 406
Citations - 34734
Serpil C. Erzurum is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 87, co-authored 353 publications receiving 29654 citations. Previous affiliations of Serpil C. Erzurum include Pulmonary Vascular Research Institute & National Institutes of Health.
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Journal ArticleDOI
Integrative proteomics and phosphoproteomics in pulmonary arterial hypertension
Weiling Xu,Suzy A.A. Comhair,Ruoying Chen,Bo Hu,Yuan Hou,Yadi Zhou,Lori Mavrakis,Allison J. Janocha,Ling Li,Dongmei Zhang,Belinda Willard,Kewal Asosingh,Feixiong Cheng,Serpil C. Erzurum,Serpil C. Erzurum +14 more
TL;DR: Global proteomics and phosphoproteomics of PAEC from PAH and healthy lungs were performed to confirm known pathways and identify new areas of investigation in PAH, indicating that PAH is typified by changes in metabolic pathways that are primarily found in mitochondria.
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The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients.
Xingnan Li,Elizabeth J. Ampleford,Timothy D. Howard,Wendy C. Moore,Huashi Li,William W. Busse,Mario Castro,Serpil C. Erzurum,Anne M. Fitzpatrick,Benjamin Gaston,Elliot Israel,Nizar N. Jarjour,W. Gerald Teague,Sally E. Wenzel,Gregory A. Hawkins,Eugene R. Bleecker,Deborah A. Meyers +16 more
TL;DR: This research highlights the need to understand more fully the role of “cell reprograming” in the development of regenerative medicine and its role in disease.
Journal ArticleDOI
Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program
Annette T. Hastie,David T. Mauger,Loren C. Denlinger,Andrea M. Coverstone,Mario Castro,Serpil C. Erzurum,Nizar N. Jarjour,Bruce D. Levy,Deborah A. Meyers,Wendy C. Moore,Brenda R. Phillips,Sally E. Wenzel,John V. Fahy,Elliot Israel,Eugene R. Bleecker +14 more
TL;DR: In this paper, some reports indicate longitudinal variability in sputum differential cell counts, whereas others describe stability Highly variable sutum eosinophil percentages are associated with gr
Journal ArticleDOI
Nascent Endothelium Initiates Th2 Polarization of Asthma
Kewal Asosingh,Georgiana Cheng,Weiling Xu,Benjamin M. Savasky,Mark A. Aronica,Xiaoxia Li,Serpil C. Erzurum +6 more
TL;DR: The results identify angiogenic responses in the origins of atopic inflammation through mechanisms that blunted endothelial IL-25 and proangiogenic progenitor cell thymic stromal lymphopoietin production.
Journal ArticleDOI
ALX receptor ligands define a biochemical endotype for severe asthma.
Isabell Ricklefs,Ioanna Barkas,Melody G. Duvall,Melody G. Duvall,Manuela Cernadas,Nicole L. Grossman,Elliot Israel,Eugene R. Bleecker,Mario Castro,Serpil C. Erzurum,John V. Fahy,Benjamin Gaston,Loren C. Denlinger,David T. Mauger,Sally E. Wenzel,Suzy A.A. Comhair,Andrea M. Coverstone,Merritt L. Fajt,Annette T. Hastie,Mats W. Johansson,Michael C. Peters,Brenda R. Phillips,Bruce D. Levy +22 more
TL;DR: An association between select ALX receptor ligands and asthma severity is established that define a potentially new biochemical endotype for asthma and support a pivotal functional role for ALX signaling in the fate of lung inflammation.