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Serpil C. Erzurum
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 406
Citations - 34734
Serpil C. Erzurum is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 87, co-authored 353 publications receiving 29654 citations. Previous affiliations of Serpil C. Erzurum include Pulmonary Vascular Research Institute & National Institutes of Health.
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Journal ArticleDOI
Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA
TL;DR: A replication deficient recombinant adenovirus containing the human catalase cDNA is able to infect human endothelial cells in vitro and express high levels of functional intracellularCatalase, protecting the cells against H2O2-mediated oxidant stress.
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Importance of hedgehog interacting protein and other lung function genes in asthma
Xingnan Li,Timothy D. Howard,Wendy C. Moore,Elizabeth J. Ampleford,Huashi Li,William W. Busse,William J. Calhoun,Mario Castro,Kian Fan Chung,Serpil C. Erzurum,Anne M. Fitzpatrick,Benjamin Gaston,Elliot Israel,Nizar N. Jarjour,W. Gerald Teague,Sally E. Wenzel,Stephen P. Peters,Gregory A. Hawkins,Eugene R. Bleecker,Deborah A. Meyers +19 more
TL;DR: A subset of normal lung function genes, including HHIP, family with sequence similarity 13, member A (FAM13A), and patched homolog 1 (PTCH1), together predict lung function abnormalities, a measure of severity in white and African American subjects with asthma.
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ATS workshop proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate.
Philip E. Silkoff,Serpil C. Erzurum,Jon O. Lundberg,Steven C. George,Nandor Marczin,John F. Hunt,Richard M. Effros,Ildiko Horvath +7 more
TL;DR: Exhaled NO measurement and NO redox assessment in EBC were the focus of an American Thoracic Society workshop that was held in Toronto in 2002 and was divided into two sections: (1) exhaled and nasal NO and (2) lung nitrogen oxide and redox Assessment using EBC.
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Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity
Suzy A. A. Comhair,Benjamin Gaston,Kristin Ricci,Jeffrey P. Hammel,Raed A. Dweik,W. Gerald Teague,Deborah A. Meyers,Elizabeth J. Ampleford,Eugene R. Bleecker,William W. Busse,William J. Calhoun,Mario Castro,Kian Fan Chung,Douglas Curran-Everett,Elliot Israel,W. Nizar Jarjour,Wendy C. Moore,Stephen P. Peters,Sally E. Wenzel,Stanley L. Hazen,Serpil C. Erzurum +20 more
TL;DR: ETS-exposure of asthmatic individuals is associated with worse lung function, higher acuity of exacerbations, more health care utilization, and greater bronchial hyperreactivity; the association of diminished systemic SOD activity to ETS exposure provides for the first time a specific oxidant mechanism by which ETS may adversely affect patients with asthma.
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Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
Xingnan Li,Gregory A. Hawkins,Elizabeth J. Ampleford,Wendy C. Moore,Huashi Li,Annette T. Hastie,Timothy D. Howard,Homer A. Boushey,William W. Busse,William J. Calhoun,Mario Castro,Serpil C. Erzurum,Elliot Israel,Robert F. Lemanske,Stanley J. Szefler,Stephen I. Wasserman,Sally E. Wenzel,Stephen P. Peters,Deborah A. Meyers,Eugene R. Bleecker +19 more
TL;DR: Genes involved in airway structure/remodeling are associated with lung function in both general populations and asthmatic subjects and genes associated with asthma susceptibility are distinct from those genes associatedwith asthma susceptibility.