S
Serpil C. Erzurum
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 406
Citations - 34734
Serpil C. Erzurum is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 87, co-authored 353 publications receiving 29654 citations. Previous affiliations of Serpil C. Erzurum include Pulmonary Vascular Research Institute & National Institutes of Health.
Papers
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Journal ArticleDOI
Decreased Cu,Zn-SOD activity in asthmatic airway epithelium: correction by inhaled corticosteroid in vivo
H. R. De Raeve,F. B. Thunnissen,F. T. Kaneko,Fuhua H. Guo,Marc J. Lewis,Mani S. Kavuru,M. Secic,Mary Jane Thomassen,Serpil C. Erzurum +8 more
TL;DR: Findings suggest loss of Cu,Zn-SOD activity in asthma is related to inflammation, perhaps through oxidant inactivation of copper and zinc-containing SOD protein.
Journal ArticleDOI
An Association between l-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype
Fernando Holguin,Suzy A. A. Comhair,Stanley A Hazen,Robert W. Powers,Sumita Khatri,Eugene R. Bleecker,William W. Busse,William J. Calhoun,Mario Castro,Anne M. Fitzpatrick,Benjamin Gaston,Elliot Israel,Nizar N. Jarjour,Wendy C. Moore,Stephen P. Peters,W. Gerald Teague,Kian Fan Chung,Serpil C. Erzurum,Sally E. Wenzel +18 more
TL;DR: In late-onset asthma phenotype, plasma ratios of L-arginine to ADMA may explain the inverse relationship of BMI to Fe(NO), and these lower L- arginine/ADMA ratios are associated with reduced lung function and increased respiratory symptom frequency, suggesting a role in the pathobiology of the late-ONSet phenotype.
Journal Article
Relevant issues in the pathology and pathobiology of pulmonary hypertension
Rubin M. Tuder,Stephen L. Archer,Peter Dorfmüller,Serpil C. Erzurum,Christophe Guignabert,Evangelos D. Michelakis,Marlene Rabinovitch,Ralph T. Schermuly,Kurt R. Stenmark,Nicholas W. Morrell +9 more
TL;DR: Dissection of the role of pulmonary inflammation in the initiation and promotion of PH has revealed a complex yet fascinating interplay with pulmonary vascular remodeling, promising to lead to novel therapeutics and diagnostics.
Journal ArticleDOI
Nitric Oxide Inhibits Inflammatory Cytokine Production by Human Alveolar Macrophages
Mary Jane Thomassen,Lisa T. Buhrow,Mary J. Connors,F. Takao Kaneko,Serpil C. Erzurum,Mani S. Kavuru +5 more
TL;DR: Findings indicate that NO is a potent inhibitor of cytokine production by stimulated human AM, and interleukin-1beta and macrophage inflammatory protein-1alpha were evaluated, and DETA NONOate was found to inhibit both of these cytokines.
Journal ArticleDOI
Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases
Xingnan Li,Elizabeth J. Ampleford,Timothy D. Howard,Wendy C. Moore,Dara G. Torgerson,Huashi Li,William W. Busse,Mario Castro,Serpil C. Erzurum,Elliot Israel,Dan L. Nicolae,Carole Ober,Sally E. Wenzel,Gregory A. Hawkins,Eugene R. Bleecker,Deborah A. Meyers +15 more
TL;DR: It is suggested that single nucleotide polymorphisms associated with both asthma and autoimmune diseases might have opposite effects on immunopathogenesis.