S
Serpil C. Erzurum
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 406
Citations - 34734
Serpil C. Erzurum is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 87, co-authored 353 publications receiving 29654 citations. Previous affiliations of Serpil C. Erzurum include Pulmonary Vascular Research Institute & National Institutes of Health.
Papers
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Journal ArticleDOI
Association of Ambient Ozone Exposure with Airway Inflammation and Allergy in Adults with Asthma
Sumita Khatri,Fernando C. Holguin,P. Barry Ryan,David M. Mannino,Serpil C. Erzurum,W. Gerald Teague +5 more
TL;DR: In adults with asthma but not controls studied during peak ozone season, increasing ozone exposure predicted lower lung function and increased biomarkers of respiratory and systemic inflammation.
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Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism
Dongkyun Kim,Quang Tam Nguyen,Juyeun Lee,Sung Hwan Lee,Allison J. Janocha,Sohee Kim,Hongnga T. Le,Nina Dvorina,Kelly Weiss,Mark J. Cameron,Kewal Asosingh,Serpil C. Erzurum,William M. Baldwin,Ju Seog Lee,Booki Min +14 more
TL;DR: It is reported that Foxp3+ regulatory T (Treg) cells are irreplaceable GC target cells in vivo, uncovering a previously unknown contribution of Treg cells during glucocorticoid-mediated treatment of inflammation and the underlying mechanisms operated via the Dex-miR-342-Rictor axis.
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Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs.
Ana Fernandez-Bustamante,Jelena Klawitter,John E. Repine,Amanda Agazio,Allison J. Janocha,Chirag Shah,Marc Moss,Ivor S. Douglas,Zung Vu Tran,Serpil C. Erzurum,Uwe Christians,Tamas Seres +11 more
TL;DR: No tidal volume-related changes were observed in the selected lung injury biomarkers of patients with healthy lungs after 60-min ventilation, which might indicate atelectrauma and lung distention.
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Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes.
Mehdi Baratchian,Jeffrey M. McManus,Mike Berk,Fumihiko Nakamura,Sanjay Mukhopadhyay,Weiling Xu,Serpil C. Erzurum,Serpil C. Erzurum,Judy Drazba,John W. Peterson,Eric A. Klein,Benjamin Gaston,Nima Sharifi,Nima Sharifi +13 more
TL;DR: In this article, the authors investigated the sex-associated TMPRSS2 and ACE2 expression in human and mouse lungs and interrogated the possibility of pharmacologic modification of their expression with anti-androgens.
Journal ArticleDOI
Breath Formate Is a Marker of Airway S-Nitrosothiol Depletion in Severe Asthma
Roby Greenwald,Anne M. Fitzpatrick,Benjamin Gaston,Nadzeya Marozkina,Serpil C. Erzurum,W. Gerald Teague +5 more
TL;DR: EBC formate concentration is significantly higher in the breath of children with asthma than in those without asthma, and this difference is related to asthma pathology and may be a product of increased catabolism of endogenous S-nitrosothiols.