S
Sho Yamasaki
Researcher at Osaka University
Publications - 195
Citations - 11586
Sho Yamasaki is an academic researcher from Osaka University. The author has contributed to research in topics: C-type lectin & Immune system. The author has an hindex of 45, co-authored 156 publications receiving 9894 citations. Previous affiliations of Sho Yamasaki include Chiba University & National Institute for Medical Research.
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Journal ArticleDOI
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Koji Atarashi,Takeshi Tanoue,Tatsuichiro Shima,Akemi Imaoka,Tomomi Kuwahara,Yoshika Momose,Genhong Cheng,Sho Yamasaki,Takashi Saito,Yusuke Ohba,Tadatsugu Taniguchi,Kiyoshi Takeda,Shohei Hori,Ivaylo I. Ivanov,Yoshinori Umesaki,Kikuji Itoh,Kenya Honda,Kenya Honda +17 more
TL;DR: Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.
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Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans
Shinobu Saijo,Satoshi Ikeda,Keiko Yamabe,Shigeru Kakuta,Harumichi Ishigame,Aoi Akitsu,Noriyuki Fujikado,Toshimasa Kusaka,Sachiko Kubo,Soo Hyun Chung,Ryohei Komatsu,Noriko Miura,Yoshiyuki Adachi,Naohito Ohno,Kazutoshi Shibuya,Natsuo Yamamoto,Kazuyoshi Kawakami,Sho Yamasaki,Takashi Saito,Shizuo Akira,Yoichiro Iwakura +20 more
TL;DR: This study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation and generates Clec4n(-/-) mice that had virtually no fungal alpha-mannan-induced cytokine production.
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Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
Eri Taniguchi Ishikawa,Tetsuaki Ishikawa,Tetsuaki Ishikawa,Yasu S. Morita,Kenji Toyonaga,Hisakata Yamada,Osamu Takeuchi,Taroh Kinoshita,Shizuo Akira,Yasunobu Yoshikai,Sho Yamasaki +10 more
TL;DR: It is demonstrated that macrophage inducible C-type lectin (Mincle) is an essential receptor for TDM, a mycobacterial cell wall glycolipid that is the most studied immunostimulatory component of M. tuberculosis.
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Mincle is an ITAM-coupled activating receptor that senses damaged cells.
TL;DR: The results suggest that Mincle is a receptor that senses nonhomeostatic cell death and thereby induces the production of inflammatory cytokines to drive the infiltration of neutrophils into damaged tissue.
Journal ArticleDOI
Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ
Kirk D. C. Jensen,Xiaoqin Su,Sunny Shin,Luke Li,Sawsan Youssef,Sho Yamasaki,Lawrence Steinman,Takashi Saito,Richard M. Locksley,Mark M. Davis,Mark M. Davis,Nicole Baumgarth,Yueh-hsiu Chien +12 more
TL;DR: The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens, and thymic selection determines the effector fate of gammad delta T cells rather than constrains their antigen specificities.