Silvano Sozzani

TL;DR: The authors show that the SAA1α isoform of serum amyloid A (SAA), which is an acute phase protein upregulated in inflammation and shown to chemoattract some leukocyte subsets, is also able to chemeattract monocyte‐derived immature dendritic cells (DCs), providing evidence that proposes a new level of regulation of leukocytes migration.

TL;DR: A better understanding of the regulation and function of TAM may provide a less empirical basis of or rational design of therapeutic approaches, as vividly illustrated by the antitumor activity of i.p. in IFN ovarian cancer patients with minimal residual disease resistant to chemotherapy.

TL;DR: Analysis of monocyte-derived and pDC-related functions of blood-circulating mononuclear cells revealed reduced interferon-α secretion in response to herpes simplex virus-1 (HSV-1), whereas granzyme-B induction upon IL-3/IL-10 stimulation was normal and T-cell costimulatory activity was lower in patients, suggesting that function and maturation of DCs is abnormal in patients with HPS2.

TL;DR: It is demonstrated that the ligation of CD300e in monocytes hampers the expression of the human leukocyte antigen (HLA) class II, affecting its synthesis, and argues against the possibility that this molecule should be considered an activating immune receptor sensu stricto.