S
Silvano Sozzani
Researcher at Sapienza University of Rome
Publications - 352
Citations - 47443
Silvano Sozzani is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 98, co-authored 335 publications receiving 43598 citations. Previous affiliations of Silvano Sozzani include University of Turin & Brescia University.
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Journal ArticleDOI
Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.
Marisa Vulcano,Cristina Albanesi,Antonella Stoppacciaro,Renzo Bagnati,Giovanna D'Amico,Sofie Struyf,Pietro Transidico,Raffaella Bonecchi,Annalisa Del Prete,Paola Allavena,Luigi Ruco,Chiara Chiabrando,Giampiero Girolomoni,Alberto Mantovani,Alberto Mantovani,Silvano Sozzani +15 more
TL;DR: Skin lesions of atopic dermatitis patients showed that CD1a+ or CD1b+ DC, and DC with a CD83+ phenotype were responsible for MDC production in this Th2‐oriented disorder, indicating that DC are the predominant source of MDC in vitro and in vivo under a variety of experimental and clinical conditions.
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Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells.
TL;DR: P- DCs appear to produce preferentially proinflammatory chemokines, but to respond selectively to homeostatic ones, whereas the reverse is true for M-DCs, highlighting not only the different migratory properties of these DC subsets, but also their capacity to recruit different cell types at inflammation sites.
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Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys.
Giovanna D'Amico,Giada Frascaroli,Giancarlo Bianchi,Pietro Transidico,Andrea Doni,Annunciata Vecchi,Silvano Sozzani,Paola Allavena,Alberto Mantovani,Alberto Mantovani +9 more
TL;DR: It is reported that concomitant exposure to proinflammatory signals and IL-10 generates functional decoy receptors in the chemokine system, which act as molecular sinks and scavengers for inflammatory chemokines in an inflammatory environment.
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Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication.
Paola Cinque,Luca Vago,Manuela Mengozzi,Valter Torri,Daniela Ceresa,Elisa Vicenzi,Pietro Transidico,Ambrogio Vagani,Silvano Sozzani,Alberto Mantovani,Adriano Lazzarin,Guido Poli +11 more
TL;DR: In vivo and in vitro findings support a model whereby HIV encephalitis is sustained by virus replication in microglial cells, a process amplified by recruitment of mononuclear cells via HIV-induced MCP-1.
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Interleukin 10 Increases CCR5 Expression and HIV Infection in Human Monocytes
Silvano Sozzani,Silvia Ghezzi,Gioacchino Iannolo,Walter Luini,Alessandro Borsatti,Nadia Polentarutti,Antonio Sica,Massimo Locati,Charles R. Mackay,Timothy N. C. Wells,Priscilla Biswas,Elisa Vicenzi,Guido Poli,Alberto Mantovani +13 more
TL;DR: IL-10–stimulated monocytes are more efficiently infected by HIV BaL and add support to an emerging paradigm in which pro- and antiinflammatory molecules exert reciprocal and opposing influence on chemokine agonist production and receptor expression.