Silvano Sozzani

TL;DR: Current knowledge on the role of tumor-associated immune cells in tumor growth and dissemination is summarized, with a specific focus on the nature of the chemotactic factors responsible for their accumulation and activation in tumors.

TL;DR: Dendritic cells differentiated in vitro from both peripheral monocytes and CD34+ cells expressed mRNA for platelet activating factor (PAF) receptor, and expression of PAF receptor was increased by TNFα, a prototypic inflammatory cytokine that induces differentiation and in vivo mobilization of DC.

TL;DR: It is shown that a prolonged exposure to hypoxia induces a cell death program which could be prevented by HIF‐1α inhibition and/or LPS maturation, and these results may contribute to further understand the physiology of DC and the molecular mechanisms involved in the survival of DC, with important implications in the regulation of the immune response.

TL;DR: Increasing understanding of the role of inflammatory mediators in inflammation and diseases is opening new avenues for the treatment of inflammatory-based diseases through selective targeting of cytokines and lipid mediators.

TL;DR: The phenomenology of endothelial cell activation by cytokines is reviewed in detail, production and action of relatively novel mediators (e.g., chemokines) are emphasized as well as the molecular basis for EC activation, and emerging clinical implications of EC activation are analyzed.