S
Silvano Sozzani
Researcher at Sapienza University of Rome
Publications - 352
Citations - 47443
Silvano Sozzani is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 98, co-authored 335 publications receiving 43598 citations. Previous affiliations of Silvano Sozzani include University of Turin & Brescia University.
Papers
More filters
Journal ArticleDOI
The viral chemokine macrophage inflammatory protein-II is a selective Th2 chemoattractant.
Silvano Sozzani,Walter Luini,Giancarlo Bianchi,Paola Allavena,Timothy N. C. Wells,Monica Napolitano,Giovanni Bernardini,Annunciata Vecchi,Daniele D’Ambrosio,D. Mazzeo,Francesco Sinigaglia,Angela Santoni,Enrico Maggi,Sergio Romagnani,Alberto Mantovani +14 more
TL;DR: InII (vMIP-II) encoded by the KS-associated herpes virus 8 was a selective chemoattractant for T helper 2 (Th2 cells) and for monocytes, whereas it was inactive on other leukocytes, including Th1 cells, dendritic cells, and natural killer (NK) cells.
Journal ArticleDOI
Human Cytomegalovirus Replicates Abortively in Polymorphonuclear Leukocytes after Transfer from Infected Endothelial Cells via Transient Microfusion Events
Giuseppe Gerna,Elena Percivalle,Fausto Baldanti,Silvano Sozzani,Paolo Lanzarini,Emilia Genini,Daniele Lilleri,Maria Grazia Revello +7 more
TL;DR: It is demonstrated that PMNLs from immunocompetent subjects may harbor both infectious human cytomegalovirus (HCMV) and viral products as early as 60 min after coculture with human umbilical vein endothelial cells (HUVEC) or human embryonic lung fibroblasts infected with a clinical HCMV isolate (VR6110) or other wild-type strains.
Journal Article
The signal transduction pathway involved in the migration induced by a monocyte chemotactic cytokine
Silvano Sozzani,Walter Luini,Marina Molino,Petr Jílek,Barbara Bottazzi,Chiara Cerletti,Kouji Matsushima,Alberto Mantovani +7 more
TL;DR: Recombinant monocyte-chemotactic and activating factor induced migration of human monocytes across polycarbonate or nitrocellulose filters revealed that rMCAF elicited true gradient-dependent chemotactic migration, although a gradient independent chemokinetic effect was observed at low concentrations.
Journal ArticleDOI
Macrophage-derived chemokine (MDC).
TL;DR: Evidence is consistent with a role of this chemokine as an amplification loop of polarized type II responses, and emerging indications on the involvement of MDC in diverse pathologies, ranging from allergic reactions to HIV infection and neoplasia are discussed.
Journal ArticleDOI
Trafficking properties of plasmacytoid dendritic cells in health and disease
TL;DR: Plasmacytoid dendritic cells are considered to be involved in the pathogenesis of diseases characterized by a type I IFN-signature and are considered as a promising target for new intervention strategies.