S
Silvano Sozzani
Researcher at Sapienza University of Rome
Publications - 352
Citations - 47443
Silvano Sozzani is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 98, co-authored 335 publications receiving 43598 citations. Previous affiliations of Silvano Sozzani include University of Turin & Brescia University.
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Journal ArticleDOI
Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors.
Alberto Mantovani,Paola Allavena,Silvano Sozzani,Annunciata Vecchi,Massimo Locati,Antonio Sica +5 more
TL;DR: Tumor-associated macrophages and dendritic cells in tumors have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression.
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Cutting edge: differential chemokine production by myeloid and plasmacytoid dendritic cells.
Giuseppe Penna,Marisa Vulcano,Andrea Roncari,Fabio Facchetti,Silvano Sozzani,Luciano Adorini +5 more
TL;DR: The high production of CCR4 ligands by M-DCs suggests their capacity to selectively recruit at sites of inflammation T cells with regulatory properties or with a Th2 phenotype, whereas P- DCs, by preferentially secreting CCR1/CCR5 ligands, would mostly recruit effector T cells and, in particular, Th1-type cells.
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Novel markers of normal and neoplastic human plasmacytoid dendritic cells
Teresa Marafioti,Jennifer C. Paterson,Erica Ballabio,Kaaren K. Reichard,Sara Tedoldi,Kevin Hollowood,Michael Dictor,Martin-Leo Hansmann,Stefano Pileri,Martin J. S. Dyer,Silvano Sozzani,Ivan Dikic,Andrey S. Shaw,Tony Petrella,Harald Stein,Peter G. Isaacson,Fabio Facchetti,David Y. Mason +17 more
TL;DR: A range of molecules (notably those associated with B cells) expressed by pDCs in tissues and peripheral blood are documented and potential new markers are defined (in particular CD2AP) for the diagnosis of pDC tumors are defined.
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New nomenclature for atypical chemokine receptors.
Françoise Bachelerie,Gerard J. Graham,Massimo Locati,Alberto Mantovani,Philip M. Murphy,Robert J. B. Nibbs,Antal Rot,Silvano Sozzani,Marcus Thelen +8 more
TL;DR: Evidence indicates that like ACKR3, other ACKRs have preserved the ability to activate b-arrestin-dependent signaling, which is required for chemokine internalization and therefore have been provisionally assigned ACKR designations and numbers that remain reserved at present.
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Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6.
Anna M. Fra,Massimo Locati,Karel Otero,Marina Sironi,Paola Signorelli,Maria L. Massardi,Marco Gobbi,Annunciata Vecchi,Silvano Sozzani,Alberto Mantovani +9 more
TL;DR: The results indicate that D6 acts as an inflammatory chemokine scavenging nonactivatory decoy receptors and suggest that in lymphatic vessels D6 may function as a gatekeeper for inflammatory CC chemokines, by clearing them and preventing excessive diffusion via afferent lymphatics to lymph nodes.