S
Silvano Sozzani
Researcher at Sapienza University of Rome
Publications - 352
Citations - 47443
Silvano Sozzani is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 98, co-authored 335 publications receiving 43598 citations. Previous affiliations of Silvano Sozzani include University of Turin & Brescia University.
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Journal ArticleDOI
The role of chemokines in the regulation of dendritic cell trafficking.
TL;DR: A better understanding of the molecular basis of DC trafficking may provide molecular and conceptual tools to direct and modulate DC traffic as a strategy to up‐regulate and orient specific immunity.
Journal ArticleDOI
Chemokine Receptor Expression and Function in CD4+ T Lymphocytes with Regulatory Activity
Silvia Sebastiani,Paola Allavena,Cristina Albanesi,Francesca Nasorri,Giancarlo Bianchi,Claudia Traidl,Silvano Sozzani,Giampiero Girolomoni,Andrea Cavani +8 more
TL;DR: Results indicate that skin-homing regulatory ThIL-10 lymphocytes coexpress functional Th1- and Th2-associated chemokine receptors, and that CCR8/I-309-driven recruitment of both resting and activated Thil-10 cells may be critically involved in the regulation of Th 1-mediated skin allergic disorders.
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Divergent Effects of Interleukin-4 and Interferon-γ on Macrophage-Derived Chemokine Production: An Amplification Circuit of Polarized T Helper 2 Responses
Raffaella Bonecchi,Silvano Sozzani,Silvano Sozzani,Silvano Sozzani,Johnny T. Stine,Johnny T. Stine,Johnny T. Stine,Walter Luini,Walter Luini,Walter Luini,Giovanna D'Amico,Giovanna D'Amico,Giovanna D'Amico,Paola Allavena,Paola Allavena,Paola Allavena,David Chantry,David Chantry,David Chantry,Alberto Mantovani,Alberto Mantovani,Alberto Mantovani +21 more
TL;DR: An amplification loop of polarized Th2 responses based on differential regulation of MDC production by IL-4 and IL-13 versus IFN-gamma and on the selectivity of this chemokine for polarized Th1 cells are delineated.
Journal Article
Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-γ in human neutrophils
Raffaella Bonecchi,Nadia Polentarutti,Walter Luini,Alessandro Borsatti,Sergio Bernasconi,Massimo Locati,Christine A. Power,Amanda E. I. Proudfoot,Timothy N. C. Wells,Charles R. Mackay,Alberto Mantovani,Alberto Mantovani,Silvano Sozzani +12 more
TL;DR: The results suggest that the selectivity of certain chemokines for their target cells may be altered by cytokines produced within an inflammatory context.
Journal ArticleDOI
Interleukin-6 Induces Monocyte Chemotactic Protein-1 in Peripheral Blood Mononuclear Cells and in the U937 Cell Line
Priscilla Biswas,Fanny Delfanti,Fanny Delfanti,Sergio Bernasconi,Sergio Bernasconi,Manuela Mengozzi,Manuela Mengozzi,Manuela Cota,Manuela Cota,Nadia Polentarutti,Nadia Polentarutti,Alberto Mantovani,Alberto Mantovani,Adriano Lazzarin,Adriano Lazzarin,Silvano Sozzani,Silvano Sozzani,Guido Poli,Guido Poli +18 more
TL;DR: IL-6 activates PBMCs to secrete MCP-1, a CC chemokine pivotal for monocyte recruitment in tissue and organs in which important inflammatory events occur, and IL-6 induction of M CP-1 was partially inhibited by hydrocortisone in U1 cells.