S
Silvano Sozzani
Researcher at Sapienza University of Rome
Publications - 352
Citations - 47443
Silvano Sozzani is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 98, co-authored 335 publications receiving 43598 citations. Previous affiliations of Silvano Sozzani include University of Turin & Brescia University.
Papers
More filters
Journal ArticleDOI
The yin and yang of Activin A.
Silvano Sozzani,Tiziana Musso +1 more
TL;DR: In this issue of Blood, Sierra-Filardi and colleagues shed new light on the still poorly understood proinflammatory role of Activin A in macrophage polarization.
Journal ArticleDOI
Role of osteopontin in dendritic cell shaping of immune responses
TL;DR: This review will focus on the role of DC-derived OPN in shaping immune response and on the complex role of this cytokines in the regulation in immune response.
Journal Article
Interleukin-1 beta primes interleukin-8-stimulated chemotaxis and elastase release in human neutrophils via its type I receptor
Laura Brandolini,Rita Sergi,Gianfranco Caselli,Diana Boraschi,Massimo Locati,Silvano Sozzani,Riccardo Bertini +6 more
TL;DR: It is shown that a brief exposure to IL-1 beta induces a potentiation of both PMN elastase release and chemotactic response to interleukin-8 (IL-8), the prototype of C-X-C chemokines.
Journal ArticleDOI
Dual regulation of osteopontin production by TLR stimulation in dendritic cells
Valentina Salvi,Sara Scutera,Silvia Rossi,Mario Zucca,Manuela Alessandria,D. Greco,Daniela Bosisio,Silvano Sozzani,Silvano Sozzani,Tiziana Musso +9 more
TL;DR: It is reported that the activation of the MyD88 pathway by TLR2, TLR5, and TLR7/8 agonists or IL‐1β induces high levels of OPN in human DCs, and implies that OPN regulation byTLR signaling is critical in shaping inflammatory responses and may modulate IL‐17 production in response to pathogens.
Journal ArticleDOI
Ligand-dependent activation of EGFR in follicular dendritic cells sarcoma is sustained by local production of cognate ligands.
William Vermi,Emanuele Giurisato,Silvia Lonardi,Piera Balzarini,Elisa Rossi,Daniela Medicina,Daniela Bosisio,Silvano Sozzani,Wilma Pellegrini,Claudio Doglioni,Antonio Marchetti,Giulio Rossi,Stefano Pileri,Fabio Facchetti +13 more
TL;DR: Activation of EGFR by cognate ligands produced in the tumor microenvironment sustain viability and proliferation of FDC-S indicating that the receptor blockade might be clinically relevant in this neoplasm.