S
Silvano Sozzani
Researcher at Sapienza University of Rome
Publications - 352
Citations - 47443
Silvano Sozzani is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 98, co-authored 335 publications receiving 43598 citations. Previous affiliations of Silvano Sozzani include University of Turin & Brescia University.
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Journal ArticleDOI
Interleukin-12 is chemotactic for natural killer cells and stimulates their interaction with vascular endothelium
TL;DR: By inducing migration and interaction with EC, IL-12 regulates crucial determinants of NK-cell recruitment in tissues, and shows significant and reproducible chemotactic response to IL- 12.
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Distinct Transcriptional Programs Activated by Interleukin-10 with or without Lipopolysaccharide in Dendritic Cells: Induction of the B Cell-Activating Chemokine, CXC Chemokine Ligand 13
Patrick Perrier,Fernando O. Martinez,Massimo Locati,Giancarlo Bianchi,Manuela Nebuloni,Gianluca Vago,Flavia Bazzoni,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Alberto Mantovani,Alberto Mantovani +11 more
TL;DR: This novel finding reveals that IL-10 sustains humoral immunity by inducing the production in APCs of the chemokine, CXCL13, which amplifies B cell recruitment and promotes lymphoid tissue neogenesis.
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CCL3 and CXCL12 regulate trafficking of mouse bone marrow NK cell subsets
Giovanni Bernardini,Giuseppe Sciumè,Daniela Bosisio,Stefania Morrone,Silvano Sozzani,Angela Santoni +5 more
TL;DR: The results suggest that the combined action of chemokines selectively regulates localization of NK cell subsets in the BM and direct their maturation and migration to the periphery.
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Phosphatidic Acid and Lysophosphatidic Acid Induce Haptotactic Migration of Human Monocytes
Dan Zhou,Walter Luini,Sergio Bernasconi,Luisa Diomede,Mario Salmona,Alberto Mantovani,Silvano Sozzani +6 more
TL;DR: Data show that phosphatidic acid induces haptotactic migration of monocytes that is at least in part receptor-mediated, and results support a role for phosphatodic acid and lysophosphatidIC acid in the regulation of leukocyte accumulation into tissues.
Journal Article
Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells.
Lucia Meda,Sergio Bernasconi,Corrada Bonaiuto,Silvano Sozzani,Dan Zhou,Laszlo Otvos,Alberto Mantovani,Filippo Rossi,Marco A. Cassatella +8 more
TL;DR: This study examines whether human monocytes and murine microglial cells stimulated with the active fragment of amyloid beta-protein (Abeta(25-35) express the monocyte chemotactic protein-1 (MCP-1)/JE, and provides evidence that the Abeta( 25-35)- and Abeta plus IFN-gamma-induced production of MCP-2 is mediated in an autocrine fashion by endogenous TNF-alpha.