Silvano Sozzani

TL;DR: This review aims at critically summarizing the current literature concerning selected aspects of DC biology that, when altered, facilitate autoimmunity, including mechanisms of tissue entry and accumulation, mechanisms of activation and orchestration of the immune balance by cytokine production.

TL;DR: HIV replication-dependent expression of MCP-1 in MP may be of particular relevance for the pathogenesis of HIV infection in nonlymphoid organs such as the brain.

TL;DR: Recent acquisitions about IFN-I biology are underline, with a focus on the relevance of the induction of some autoimmune diseases, such as systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, dermato/polymiositis, and Sjogren's syndrome.

TL;DR: The results presented here show that the Cys-Cys chemokines MCP-1, LD78/MIP1 alpha, and RANTES cause rapid release of arachidonic acid in monocytes and that this may be important in inducing monocyte chemotaxis.

TL;DR: A new recombinant vector, MVMp/IP-10 is created, transducing the immunoactive, antiangiogenic chemokine IP-10, and used to treat syngeneic tumors grown in immunocompetent mice, demonstrating that MVMs can aid the treatment of vascular tumors and that autonomous parvovirus-based vectors can be considered potent tools for cancer gene therapy purposes.