Silvano Sozzani

TL;DR: The set of molecules identified in the present study is probably important in determining the prominent leukocyte infiltration observed in KS, and may amplify autocrine/paracrine circuits that sustain KS proliferation and contribute to recruitment of host vascular cells.

TL;DR: In an established in vivo glioma model, repeated simultaneous peritumoral injection of the IP-10- and TNF-α-delivering parvoviruses failed to improve the therapeutic effect as compared with the use of a single cytokine-del delivering vector, suggesting cytokine -mediated immunostimulation, rather than inhibition of vascularization, is likely responsible for the therapeutic efficacy.

TL;DR: In vivo data indicate that the angiostatic property of CXCL4L1 is equally important in retarding tumor growth and Chemotaxis of T cells, natural killer cells, and DCs is likely to contribute to the antitumoral action.

TL;DR: The spectrum of action of chemokines encompasses a large number of leukocyte populations, including monocytes, granulocytes, lymphocytes, NK and dendritic cells as discussed by the authors.

TL;DR: Sequence analysis as well as Northern blotting and RNase protection with different probes revealed that the CCR2 gene is expressed in activated NK cells and mononuclear phagocytes as a predominant long transcript, which is polyadenylated and present in the cytoplasm.