S
Silvano Sozzani
Researcher at Sapienza University of Rome
Publications - 352
Citations - 47443
Silvano Sozzani is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 98, co-authored 335 publications receiving 43598 citations. Previous affiliations of Silvano Sozzani include University of Turin & Brescia University.
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Journal Article
OM-85 shapes dendritic cell activation into a “pre-alert” phenotype
Daniela Bosisio,Laura Salogni,Natacha Nowak,Xenia Vaira,Patricia Jeandet,Gabriela Saborio,Silvano Sozzani +6 more
TL;DR: It was identified that OM-85 activates TLR2, NOD1 and NOD2 receptors in a significant, dose-response manner and may contribute to the generation of a “pre-alert state” resulting in early protection towards incoming infection.
Journal ArticleDOI
Chemokine receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
Françoise Bachelerie,Adit Ben-Baruch,Amanda M. Burkhardt,Israel F. Charo,Christophe Combadière,Reinhold Förster,Joshua M. Farber,Gerard J. Graham,Rebecca Hills,Richard Horuk,Massimo Locati,Andrew D. Luster,Alberto Mantovani,Kouji Matsushima,Amy E. Monaghan,Georgios Leandros Moschovakis,Philip M. Murphy,Robert J. B. Nibbs,Hisayuki Nomiyama,Joost J. Oppenheim,Christine A. Power,Amanda E. I. Proudfoot,Mette M. Rosenkilde,Antal Rot,Silvano Sozzani,Alexander Hovard Sparre-Ulrich,Marcus Thelen,Mohib Uddin,Osamu Yoshie,Albert Zlotnik +29 more
TL;DR: Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [431, 430, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically possessing chemotactic activity for leukocytes.
Book ChapterDOI
Transendothelial migration and reverse transmigration of in vitro cultured human dendritic cells.
TL;DR: Dendritic cells are migratory cells that exhibit complex trafficking properties in vivo, involving interaction with vascular and lymphatic endothelium and extracellular matrix (ECM).
Book ChapterDOI
Chemotaxis and interaction with vascular or lymphatic endothelium.
Journal ArticleDOI
Age-dependent NK cell dysfunctions in severe COVID-19 patients
Cinzia Fionda,Silvia Ruggeri,Giuseppe Sciumè,Mattia Laffranchi,Isabella Quinti,Cinzia Milito,Paolo Palange,Ilaria Menichini,Silvano Sozzani,Luigi Frati,Angela Gismondi,Angela Santoni,Helena Stabile +12 more
TL;DR: In this paper , the authors investigated the age-related changes of NK cell phenotype and function during SARS-CoV-2 infection, by comparing adult and elderly patients both requiring mechanical ventilation.