Silvano Sozzani

TL;DR: This work reviews this extended family of chemokine receptors and Chemokine-binding proteins at the basic, translational, and clinical levels, including an update on drug development and introduces a new nomenclature for atypical chemokin receptors with the stem ACKR (atypicalChemokine receptor).

TL;DR: These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community providing the theory and key practical aspects offlow cytometry enabling immunologists to avoid the common errors that often undermine immunological data.

TL;DR: Concomitantly, the expression of CCR7 and the migration to its ligand EBI1 ligand chemokine (ELC)/macrophage inflammatory protein (MIP)-3beta, a chemokines expressed in lymphoid organs, were strongly up-regulated, though with slower kinetics (24-48 h).

TL;DR: Northern analyses indicated MDC is highly expressed in macrophages and in monocyte-derived dendritic cells, but not in monocytes, natural killer cells, or several cell lines of epithelial, endothelial, or fibroblast origin, which indicated a unique member of the CC chemokine family that may play a fundamental role in the function of dendrite cells, natural Killer cells, and monocytes.

TL;DR: It is found that SAHA reduces the production of proinflammatory cytokines in vivo and in vitro and may stimulate the expression of genes that control the synthesis of cytokines and nitric oxide or hyperacetylate other targets.