S
Silvano Sozzani
Researcher at Sapienza University of Rome
Publications - 352
Citations - 47443
Silvano Sozzani is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 98, co-authored 335 publications receiving 43598 citations. Previous affiliations of Silvano Sozzani include University of Turin & Brescia University.
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Book ChapterDOI
Chemokines and Chemokine Receptors
Alberto Mantovani,Paola Allavena,Cecilia Garlanda,Simona Ramponi,C. Paganini,Annunciata Vecchi,Silvano Sozzani +6 more
TL;DR: Classic chemoattractants include complement components, formyl peptides and leukotriene B4, and various cytokines are able to elicit directional migration of leukocytes.
Book ChapterDOI
The Targeting of Leukocytes by 5-Oxo-Eicosanoids
Joseph T. O'Flaherty,Mitsuyuki Kuroki,Larry W. Daniel,Robert L. Wykle,Andrew B. Nixon,Silvano Sozzani +5 more
TL;DR: A newly defined 5-HETE analog, 5-oxoETE, has in vitro actions suggesting that it could be such a mediator in vivo, and an eicosatetraenoate (ETE) may link Eo to allergy.
Journal ArticleDOI
Human Metapneumovirus Establishes Persistent Infection in Lung Microvascular Endothelial Cells and Primes a Th2-Skewed Immune Response
Antonella Bugatti,Stefania Marsico,Manuela Fogli,Sara Roversi,Serena Messali,Daniela Bosisio,Cinzia Giagulli,Arnaldo Caruso,Silvano Sozzani,Simona Fiorentini,Francesca Caccuri +10 more
TL;DR: It is shown that HMPV productively infects human lung microvascular endothelial cells (L-HMVECs) and that HmpV, per se, could reproduce the ability of secretome to prime pro-Th2 DCs, suggesting that H MPV might take part in the development of a skewed, pro- Th2 lung microenvironment.
Journal ArticleDOI
The Chemerin/ChemR23 Axis Plays a Pivotal Role in the Pathogenesis of Intestinal Damage in a Murine Model of Graft Versus Host Disease
Paola Vinci,Camilla Recordati,Donatella Bardelli,Claudia Cappuzzello,Valeria Fumagalli,Erica Dander,Annalisa Del Prete,Silvano Sozzani,Andrea Biondi,Giovanna D'Amico +9 more
TL;DR: In this paper, the authors evaluated the potential role of Chemerin/ChemR23 axis in the pathogenesis of GvHD, in order to identify disease-specific pathways exploitable for developing new potential therapeutic targets.
Journal ArticleDOI
The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation
Hoang Nguyen,Valentina Salvi,Laura Tiberio,Fabio Facchinetti,Mirco Govoni,Gino Villetti,Maurizio Civelli,Ilaria Barbazza,Carolina Gaudenzi,Mauro Passari,Tiziana Schioppa,Francesca Sozio,Annalisa Del Prete,Silvano Sozzani,Daniela Bosisio +14 more
TL;DR: Tanimilast is a selective inhaled inhibitor of phosphodiesterase-4 in advanced clinical development for chronic obstructive pulmonary disease (COPD), which is known to exert prominent anti-inflammatory activity when tested in preclinical experimental models as well as in human clinical studies as discussed by the authors .